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Self-assembled targeted folate-conjugated eight-arm-polyethylene glycol-betulinic acid nanoparticles for co-delivery of anticancer drugs
Dai, Lin1; Cao, Xin1; Liu, Ke-Feng1; Li, Chun-Xiao1; Zhang, Gui-Feng2; Deng, Li-Hong1; Si, Chuan-Ling3; He, Jing1; Lei, Jian-Du1
2015
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
Volume3Issue:18Pages:3754-3766
Abstract

In this study, a targeted nanoparticle platform for co-delivery of anticancer drugs based on folate-conjugated eight-arm-polyethylene glycol-betulinic acid (F-8arm-PEG-BA) was first presented. F-8arm-PEG-BA was synthesized by introducing target molecules (folate) and drug molecules (betulinic acid, BA) to hydrophilic molecules (8arm-PEG). Then another anticancer drug, hydroxycamptothecin (HCPT), was encapsulated into the self-assembled nanoparticles from the conjugate by a simple nanoprecipitation method. These F-8arm-PEG-BA/HCPT nanoparticles (NPs) had a small size (similar to 120 nm), acceptable critical aggregation concentration (similar to 64.8 mu g mL(-1)), and high drug loading (similar to 18 wt% BA and similar to 16 wt% HCPT). Compared to the free drugs, the nanoparticles significantly improved the cellular cytotoxicity and exhibited an obvious synergistic effect by the co-delivery of two different anticancer drugs, BA and HCPT. Pharmacokinetics study revealed the nanoparticles could prolong the circulation of BA and HCPT in the blood. In vivo studies indicated that the nanoparticles enhanced tumor targeting and antitumor activity with lower systemic toxicity. In conclusion, F-8arm-PEG-BA/HCPT NPs have great potential for targeted chemotherapy for cancer.

SubtypeArticle
WOS HeadingsScience & Technology ; Technology
DOI10.1039/c5tb00042d
Indexed BySCI
Language英语
WOS KeywordPoly(Ethylene Glycol) ; Surface-properties ; Mediated Delivery ; Cancer-treatment ; Particle-size ; Release ; Mechanisms ; Polymers ; Receptor ; Prodrugs
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, bioMaterials
WOS IDWOS:000353656400011
Citation statistics
Cited Times:25[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/16755
Collection研究所(批量导入)
Affiliation1.Beijing Forestry Univ, Beijing Key Lab Lignocellulos Chem, Beijing 100083, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Beijing 100090, Peoples R China
3.Tianjin Univ Sci & Technol, Coll Mat Sci & Chem Engn, Tianjin Key Lab Pulp & Paper, Tianjin 300457, Peoples R China
Recommended Citation
GB/T 7714
Dai, Lin,Cao, Xin,Liu, Ke-Feng,et al. Self-assembled targeted folate-conjugated eight-arm-polyethylene glycol-betulinic acid nanoparticles for co-delivery of anticancer drugs[J]. JOURNAL OF MATERIALS CHEMISTRY B,2015,3(18):3754-3766.
APA Dai, Lin.,Cao, Xin.,Liu, Ke-Feng.,Li, Chun-Xiao.,Zhang, Gui-Feng.,...&Lei, Jian-Du.(2015).Self-assembled targeted folate-conjugated eight-arm-polyethylene glycol-betulinic acid nanoparticles for co-delivery of anticancer drugs.JOURNAL OF MATERIALS CHEMISTRY B,3(18),3754-3766.
MLA Dai, Lin,et al."Self-assembled targeted folate-conjugated eight-arm-polyethylene glycol-betulinic acid nanoparticles for co-delivery of anticancer drugs".JOURNAL OF MATERIALS CHEMISTRY B 3.18(2015):3754-3766.
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