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A thermosensitive hydrogel based on quaternized chitosan and poly(ethylene glycol) for nasal drug delivery system
Wu, Jie; Wei, Wei; Wang, Lian-Yan; Su, Zhi-Guo; Ma, Guang-Hui
2007-04-01
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume28Issue:13Pages:2220-2232
AbstractA new thermosensitive hydrogel was designed and prepared by simply mixing N-[(2-hydroxy-3-trimethylammonium) propyl] chitosan chloride (HTCC) and poly(ethylene glycol) (PEG) with a small amount of alpha,-beta-glycerophosphate (alpha-beta-GP). The optimum preparative condition was investigated, and the obtained formulation underwent thermal transition from solution below or at room temperature to non-flowing hydrogel around 37 degrees C in several minutes. As a new formulation, its potential use as nasal drug delivery system was studied. It can be dropped or sprayed easily into nasal cavity and spread on the nasal mucosa in solution state. After being administered into nasal cavity, the solution transformed into viscous hydrogel at body temperature, which decreased nasal mucociliary clearance rate and released drug slowly. Morever, quaternized chitosan as absorption enhancer has been studied extensively in several reports and proved its non-toxicity, mucoadhesivity and the capacity to open the tight junctions between epithelial cells. Therefore, in this study insulin as a model drug was entrapped in this formulation and its release behavior in vitro was also investigated. The enhancement of absorption of fluorescein isothiocyanate (FITC)-labeled insulin in rat nasal cavity by this formulation was proved by confocal laser scanning microscopy (CLSM). The cytoxicity and the change of the blood glucose concentration after nasal administration of this hydrogel were also investigated. The hydrogel formulation decreased the blood glucose concentration apparently (40-50% of initial blood glucose concentration) for at least 4-5 h after administration, and no apparent cytoxicity was found after application. These results showed that HTCC-PEG-GP formulation can be used as nasal drug delivery system to improve the absorption of hydrophilic macromolecular drugs. (c) 2007 Elsevier Ltd. All rights reserved.
KeywordN-[(2-hydroxy-3-trimethylammonium) Propyl] Chitosan Chloride Poly(Ethylene Glycol) Hydrogel Nasal Drug Delivery System Absorption Enhancer
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
DOI10.1016/j.biomaterials.2006.12.024
Indexed BySCI
Language英语
WOS KeywordN-TRIMETHYL CHITOSAN ; IN-VITRO ; INSULIN DELIVERY ; ABSORPTION ; VIVO ; CHLORIDE ; ENHANCEMENT ; PROTEINS ; RELEASE ; ENZYMES
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
WOS IDWOS:000244947100007
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/19216
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Proc Chem, State Key Lab Biochem Engn, Beijing 100080, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Wu, Jie,Wei, Wei,Wang, Lian-Yan,et al. A thermosensitive hydrogel based on quaternized chitosan and poly(ethylene glycol) for nasal drug delivery system[J]. BIOMATERIALS,2007,28(13):2220-2232.
APA Wu, Jie,Wei, Wei,Wang, Lian-Yan,Su, Zhi-Guo,&Ma, Guang-Hui.(2007).A thermosensitive hydrogel based on quaternized chitosan and poly(ethylene glycol) for nasal drug delivery system.BIOMATERIALS,28(13),2220-2232.
MLA Wu, Jie,et al."A thermosensitive hydrogel based on quaternized chitosan and poly(ethylene glycol) for nasal drug delivery system".BIOMATERIALS 28.13(2007):2220-2232.
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