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Site-Specific Drug-Releasing Polypeptide Nanocarriers Based on Dual-pH Response for Enhanced Therapeutic Efficacy against Drug-Resistant Tumors
Dong, Yaqiong1,2; Yang, Jun1; Liu, Hongmei1,3; Wang, Tianyou4; Tang, Suoqin5; Zhang, Jinchao2; Zhang, Xin1
2015
Source PublicationTHERANOSTICS
ISSN1838-7640
Volume5Issue:8Pages:890-904
Abstract

To enhance effective drug accumulation in drug-resistant tumors, a site-specific drug-releasing polypeptide system (PEG-Phis/Pasp-DOX/CA4) was exploited in response to tumor extracellular and intracellular pH. This system could firstly release the embedded tumor vascular inhibitor (CA4) to transiently 'normalize' vasculature and facilitate drug internalization to tumors efficiently, and then initiate the secondary pH-response to set the conjugated active anticancer drug (DOX) free in tumor cells. The encapsulated system (PEG-Phis/DOX/CA4), both CA4 and DOX embedding in the nanoparticles, was used as a control. Comparing with PEG-Phis/DOX/CA4, PEG-Phis/Pasp-DOX/CA4 exhibited enhanced cytotoxicity against DOX-sensitive and DOX-resistant cells (MCF-7 and MCF-7/ADR). Moreover, PEG-Phis/Pasp-DOX/CA4 resulted in enhanced therapeutic efficacy in drug-resistant tumors with reduced toxicity. These results suggested that this site-specific drug-releasing system could be exploited as a promising treatment for cancers with repeated administration.

KeywordPolypeptide Nanocarriers Site-specific Releasing Combination Cancer Therapy Dual-ph Response Drug Resistance
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.7150/thno.11821
Indexed BySCI
Language英语
WOS KeywordPOLYMERIC MICELLES ; VASCULAR NORMALIZATION ; MULTIDRUG-RESISTANCE ; DELIVERY-SYSTEM ; NANOPARTICLES ; CANCER ; DOXORUBICIN ; AGENTS ; CELLS ; GLYCOPROTEIN
WOS Research AreaResearch & Experimental Medicine
WOS SubjectMedicine, Research & Experimental
WOS IDWOS:000354959900009
Citation statistics
Cited Times:26[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/19239
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Hebei Univ, Coll Chem & Environm Sci, Chem Biol Key Lab Hebei Prov, Key Lab Med Chem & Mol Diag,Minist Educ, Baoding 071002, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Capital Inst Pediat, Beijing 100020, Peoples R China
5.Gen Hosp Peoples Liberat Army, Dept Pediat, Beijing 100853, Peoples R China
Recommended Citation
GB/T 7714
Dong, Yaqiong,Yang, Jun,Liu, Hongmei,et al. Site-Specific Drug-Releasing Polypeptide Nanocarriers Based on Dual-pH Response for Enhanced Therapeutic Efficacy against Drug-Resistant Tumors[J]. THERANOSTICS,2015,5(8):890-904.
APA Dong, Yaqiong.,Yang, Jun.,Liu, Hongmei.,Wang, Tianyou.,Tang, Suoqin.,...&Zhang, Xin.(2015).Site-Specific Drug-Releasing Polypeptide Nanocarriers Based on Dual-pH Response for Enhanced Therapeutic Efficacy against Drug-Resistant Tumors.THERANOSTICS,5(8),890-904.
MLA Dong, Yaqiong,et al."Site-Specific Drug-Releasing Polypeptide Nanocarriers Based on Dual-pH Response for Enhanced Therapeutic Efficacy against Drug-Resistant Tumors".THERANOSTICS 5.8(2015):890-904.
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