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Particle Design of Membrane Emulsification for Protein Drug and Vaccine Delivery
Wang, Lianyan; Yang, Tingyuan; Ma, Guanghui
2015
Source PublicationCURRENT PHARMACEUTICAL DESIGN
ISSN1381-6128
Volume21Issue:19Pages:2563-2598
AbstractBiodegradable particles have important applications in Drug Delivery Systems (DDS) of protein/peptide drugs. And recently, particle systems have also showed to be powerful for vaccine delivery (adjuvant) in order to solve the difficulties when conventional Alum adjuvant was used. However, in above applications, the problems of broad size distribution and poor reproducibility of particles, and deactivation of protein during the preparation, storage and release, are still big challenges. Furthermore, particle should be designed specially according to antigen type and purpose in vaccine delivery. In this article, the techniques to control the diameter of microparticle (MP) will be introduced at the first, and then the strategies about how to maintain the bioactivity of protein drugs during preparation and drug release will be reviewed. Furthermore, particle application specially designed for vaccine delivery to enhance both humoral response and cellular response, will be described.
KeywordMembrane Emulsification Protein/peptide Drugs Microparticle Adjuvant Bioactivity
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS KeywordSIZED CHITOSAN MICROSPHERES ; SOLVENT EVAPORATION METHOD ; MEDIATED IMMUNE-RESPONSES ; DOUBLE EMULSION TECHNIQUE ; LOADED PLGA MICROSPHERES ; ORAL DELIVERY ; IN-VITRO ; CONTROLLED-RELEASE ; PLA MICROCAPSULES ; DENDRITIC CELLS
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000354609400004
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/19249
Collection生化工程国家重点实验室
AffiliationInst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Wang, Lianyan,Yang, Tingyuan,Ma, Guanghui. Particle Design of Membrane Emulsification for Protein Drug and Vaccine Delivery[J]. CURRENT PHARMACEUTICAL DESIGN,2015,21(19):2563-2598.
APA Wang, Lianyan,Yang, Tingyuan,&Ma, Guanghui.(2015).Particle Design of Membrane Emulsification for Protein Drug and Vaccine Delivery.CURRENT PHARMACEUTICAL DESIGN,21(19),2563-2598.
MLA Wang, Lianyan,et al."Particle Design of Membrane Emulsification for Protein Drug and Vaccine Delivery".CURRENT PHARMACEUTICAL DESIGN 21.19(2015):2563-2598.
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