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Erythrocyte membrane-coated NIR-triggered biomimetic nanovectors with programmed delivery for photodynamic therapy of cancer
Ding, Hui1; Lv, Yanlin1; Ni, Dezhi2; Wang, Jie1; Tian, Zhiyuan1; Wei, Wei2; Ma, Guanghui2
2015
Source PublicationNANOSCALE
ISSN2040-3364
Volume7Issue:21Pages:9806-9815
Abstract

A new type of photodynamic therapy (PDT) agents using upconversion nanoparticles (UCNPs) with incorporated photosensitizers as the inner core and an erythrocyte membrane (RM) decorated with dual targeting moieties as the cloak is developed. Owing to the endogenous nature of RM, the RM-coating endows the PDT agents with perfect biocompatibility and stealth ability to escape from the entrapment by the reticulo-endothelial system (RES). More importantly, owing to the unique nature of erythrocyte as an oxygen carrier in the blood, the RM outer layer of the agents unequivocally facilitates the permeation of ground-state molecular oxygen (O-3(2)) and the singlet oxygen (O-1(2)) as compared to the previously developed PDT agents with other types of coating. Another salient feature of the as-prepared PDT platform is the decoration of RM with dual targeting moieties for selective recognition of cancer cells and mitochondrial targeting, respectively. The synergistic effect of RM coating and dual-targeting of such feature-packed agents are investigated in tumor-bearing mice and the improved PDT therapeutic efficacy is confirmed, which is the first paradigm where RM-coated NIR-triggered nanovectors with programmed delivery ability is applied in PDT of tumor in vivo.

SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
DOI10.1039/c5nr02470f
Indexed BySCI
Language英语
WOS KeywordUP-CONVERSION NANOPARTICLES ; NEAR-INFRARED LIGHT ; RED-BLOOD-CELLS ; DRUG-DELIVERY ; CHITOSAN NANOPARTICLES ; THERAPEUTICS ; PHOTOSENSITIZERS ; NANOTRANSDUCERS ; NANOPLATFORM ; CHEMOTHERAPY
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS IDWOS:000354983100057
Citation statistics
Cited Times:52[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/19251
Collection生化工程国家重点实验室
Affiliation1.Univ Chinese Acad Sci, Sch Chem & Chem Engn, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Ding, Hui,Lv, Yanlin,Ni, Dezhi,et al. Erythrocyte membrane-coated NIR-triggered biomimetic nanovectors with programmed delivery for photodynamic therapy of cancer[J]. NANOSCALE,2015,7(21):9806-9815.
APA Ding, Hui.,Lv, Yanlin.,Ni, Dezhi.,Wang, Jie.,Tian, Zhiyuan.,...&Ma, Guanghui.(2015).Erythrocyte membrane-coated NIR-triggered biomimetic nanovectors with programmed delivery for photodynamic therapy of cancer.NANOSCALE,7(21),9806-9815.
MLA Ding, Hui,et al."Erythrocyte membrane-coated NIR-triggered biomimetic nanovectors with programmed delivery for photodynamic therapy of cancer".NANOSCALE 7.21(2015):9806-9815.
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