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Microcosmic Mechanism of Dication for Inhibiting Acylation of Acidic Peptide
Qi, Feng1,4; Yang, Liuqing2; Wu, Jie1; Ma, Guanghui1,3; Su, Zhiguo1,3
2015-07-01
Source PublicationPHARMACEUTICAL RESEARCH
ISSN0724-8741
Volume32Issue:7Pages:2310-2317
Abstract

For long-effective peptide formulation based on poly(d,l-lactic-co-glycolic acid) (PLGA) microspheres, acylation often leads to peptide instability during its release and reduced drug efficacy. Among the reported solving strategies, adding dication such as Ca2+ and Mn2+ in the formulation was the most convenient method for inhibiting basic peptide acylation. However, the strategies for the acidic peptide still remain unexplored, possibly due to the peptide's changeable charge state in acid environment within degraded PLGA microspheres. Moreover, the previous studies mainly focusing on the macroscopical adsorption of peptide to PLGA cannot demonstrate the inhibition mechanism.

KeywordAcidic Peptide Acylation Exenatide Plga Qcm-d
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences ; Life Sciences & Biomedicine
DOI10.1007/s11095-015-1622-5
Indexed BySCI
Language英语
WOS KeywordLOADED PLGA MICROSPHERES ; DRUG EXENATIDE ; RELEASE ; FORMULATION ; STABILITY ; POLY(D,L-LACTIDE-CO-GLYCOLIDE) ; COPOLYMERS ; DELIVERY ; VIVO
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS IDWOS:000355264100014
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Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/19266
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, PLA Key Lab Biopharmaceut Prod & Formulat Engn, Beijing 100190, Peoples R China
2.Yanshan Univ, Inst Environm & Chem Engn, Qinhuangdao 066004, Peoples R China
3.Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300072, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Qi, Feng,Yang, Liuqing,Wu, Jie,et al. Microcosmic Mechanism of Dication for Inhibiting Acylation of Acidic Peptide[J]. PHARMACEUTICAL RESEARCH,2015,32(7):2310-2317.
APA Qi, Feng,Yang, Liuqing,Wu, Jie,Ma, Guanghui,&Su, Zhiguo.(2015).Microcosmic Mechanism of Dication for Inhibiting Acylation of Acidic Peptide.PHARMACEUTICAL RESEARCH,32(7),2310-2317.
MLA Qi, Feng,et al."Microcosmic Mechanism of Dication for Inhibiting Acylation of Acidic Peptide".PHARMACEUTICAL RESEARCH 32.7(2015):2310-2317.
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