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Subcritical water extraction of betulinic acid from birch bark
Liu, Jing1,2; Chen, Pan1; Yao, Wenjia1; Wang, Jia1; Wang, Luying1; Deng, Lihong1; He, Jing1; Zhang, Guifeng3; Lei, Jiandu1,2
2015-11-15
Source PublicationINDUSTRIAL CROPS AND PRODUCTS
ISSN0926-6690
Volume74Issue:NOVPages:557-565
AbstractAn alternative and green method for extraction of betulinic acid (BA) from birch bark is here proposed as Subcritical Water Extraction (SWE). Using response surface methodology (RSM), optimization was conducted on reaction parameters for maximum extraction yield of BA. Optimal modifying conditions are as follows: extraction time of 27.37 min, extraction temperature at 184.52 degrees C and a solvent/solid ratio of 59.60 mL/g. Under optimal conditions, the maximum BA yield was 28.03 mg/10 g birch bark. Extracts by different methods (leaching extraction, reflux extraction, ultrasonic extraction, and SWE) were comparatively and quantitatively analyzed, using High Performance Liquid Chromatography (HPLC). Results show BA yields by SWE are higher than those obtained using ethanol, a traditional extraction method, plus the extract contained fewer impurities. Furthermore, the extraction processes for all four of the above methods were modeled and reviewed individually. (C) 2015 Elsevier B.V. All rights reserved.
KeywordSubcritical Water Extraction Betulinic Acid Response Surface Methodology Modeling Hplc
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.indcrop.2015.05.064
Indexed BySCI
Language英语
WOS KeywordRESPONSE-SURFACE METHODOLOGY ; ASSISTED EXTRACTION ; OLEANOLIC ACID ; OPTIMIZATION ; POLYSACCHARIDES ; INHIBITION ; MECHANISM ; DESIGN ; PHASE ; SEEDS
WOS Research AreaAgriculture
WOS SubjectAgricultural Engineering ; Agronomy
WOS IDWOS:000360948900073
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/19532
Collection生化工程国家重点实验室
Affiliation1.Beijing Forestry Univ, Beijing Key Lab Lignocellulos Chem, Beijing 100083, Peoples R China
2.Beijing Forestry Univ, MOE Key Lab Wooden Mat Sci & Applicat, Beijing 100083, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, Beijing 100090, Peoples R China
Recommended Citation
GB/T 7714
Liu, Jing,Chen, Pan,Yao, Wenjia,et al. Subcritical water extraction of betulinic acid from birch bark[J]. INDUSTRIAL CROPS AND PRODUCTS,2015,74(NOV):557-565.
APA Liu, Jing.,Chen, Pan.,Yao, Wenjia.,Wang, Jia.,Wang, Luying.,...&Lei, Jiandu.(2015).Subcritical water extraction of betulinic acid from birch bark.INDUSTRIAL CROPS AND PRODUCTS,74(NOV),557-565.
MLA Liu, Jing,et al."Subcritical water extraction of betulinic acid from birch bark".INDUSTRIAL CROPS AND PRODUCTS 74.NOV(2015):557-565.
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