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Nanotheranostics: Congo Red/Rutin-MNPs with Enhanced Magnetic Resonance Imaging and H2O2-Responsive Therapy of Alzheimer's Disease in APPswe/PS1dE9 Transgenic Mice
Hu, Bingbing1,2; Dai, Fengying3; Fan, Zhanming4; Ma, Guanghui1; Tang, Qunwei2; Zhang, Xin1
2015-10-07
Source PublicationADVANCED MATERIALS
ISSN0935-9648
Volume27Issue:37Pages:5499-5505
Abstract

As nanotheranostics, Congo red/Rutin-MNPs combine the abilities of diagnosis and treatment of Alzheimer's disease (AD). The biocompatible nanotheranostics system based on iron oxide magnetic nanoparticles, with ultrasmall size and excellent magnetic properties, can specifically detect amyloid plaques by magnetic resonance imaging, realize targeted delivery of AD therapeutic agents, achieve drug controlled release by H2O2 response, and prevent oxidative stress.

SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
DOI10.1002/adma.201502227
Indexed BySCI
Language英语
WOS KeywordSUPERPARAMAGNETIC IRON-OXIDE ; BLOOD-BRAIN-BARRIER ; MRI CONTRAST AGENTS ; A-BETA PLAQUES ; OXIDATIVE STRESS ; AMYLOID PLAQUES ; T-2 CONTRAST ; MOUSE-BRAIN ; NANOPARTICLES ; DELIVERY
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000362727900005
Citation statistics
Cited Times:42[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/19644
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Ocean Univ China, Inst Mat Sci & Engn, Qingdao 266100, Peoples R China
3.Beijing Ctr Phys & Chem Anal, Beijing 100084, Peoples R China
4.Capital Univ, Beijing Anzhen Hosp, Dept Radiol, Beijing 100029, Peoples R China
Recommended Citation
GB/T 7714
Hu, Bingbing,Dai, Fengying,Fan, Zhanming,et al. Nanotheranostics: Congo Red/Rutin-MNPs with Enhanced Magnetic Resonance Imaging and H2O2-Responsive Therapy of Alzheimer's Disease in APPswe/PS1dE9 Transgenic Mice[J]. ADVANCED MATERIALS,2015,27(37):5499-5505.
APA Hu, Bingbing,Dai, Fengying,Fan, Zhanming,Ma, Guanghui,Tang, Qunwei,&Zhang, Xin.(2015).Nanotheranostics: Congo Red/Rutin-MNPs with Enhanced Magnetic Resonance Imaging and H2O2-Responsive Therapy of Alzheimer's Disease in APPswe/PS1dE9 Transgenic Mice.ADVANCED MATERIALS,27(37),5499-5505.
MLA Hu, Bingbing,et al."Nanotheranostics: Congo Red/Rutin-MNPs with Enhanced Magnetic Resonance Imaging and H2O2-Responsive Therapy of Alzheimer's Disease in APPswe/PS1dE9 Transgenic Mice".ADVANCED MATERIALS 27.37(2015):5499-5505.
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