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Effective Two-Photon Excited Photodynamic Therapy of Xenograft Tumors Sensitized by Water-Soluble Bis(arylidene)cycloalkanone Photosensitizers
Zou, Qianli1,4; Zhao, Hongyou2; Zhao, Yuxia1; Fang, Yanyan1,3; Chen, Defu2; Ren, Jie2; Wang, Xiaopu1,3; Wang, Ying2; Gu, Ying2; Wu, Feipeng1
2015-10-22
Source PublicationJOURNAL OF MEDICINAL CHEMISTRY
ISSN0022-2623
Volume58Issue:20Pages:7949-7958
AbstractA series of bis(arylidene)cydoalkanone photo-sensitizers modified by polyethylene glycol (PEG) have been studied for two-photon excited photodynamic therapy (2PE-PDT). As compared with their prototype compounds, these PEGylated photosensitizers show enhanced water solubilities while their photophysical and photochemical properties, including linear absorption, two-photon absorption, fluorescence, and singlet oxygen quantum yield, remain unaltered. In vitro behaviors (cellular uptake, subcellular localization, photocytotomicity in both PDT and 2PE-PDT) of these photosensitizers reveal that an optimized lipid-water partition coefficient can be obtained by adjusting the length and position of the PEG chains. Among them, the photosensitizer modified asymmetrically by two tetraethylene glycol chains presents the best performance as a 2PE-PDT candidate. Selective blood-vessel closure and obvious therapeutic effect in inhibiting the growth of tumors are confirmed by in vivo 2PE-PDT after intravenous injection of this photosensitiezer. The survival periods of treated tumor-bearing mice are significantly prolonged. This study demonstrates the feasibility of using a simple molecule to construct a potential candidate for 2PE-PDT.
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1021/acs.jmedchem.5b00731
Indexed BySCI
Language英语
WOS KeywordSINGLET OXYGEN ; BIOLOGICAL EVALUATION ; SILICA NANOPARTICLES ; EXCITATION ; ABSORPTION ; DESIGN ; CANCER ; CELLS ; DYES ; STANDARDS
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal
Funding OrganizationNational Natural Science Foundation of China(60978057)
WOS IDWOS:000363915600006
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/19759
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Tech Inst Phys & Chem, Beijing 100190, Peoples R China
2.Chinese Peoples Liberat Army Gen Hosp, Dept Laser Med, Beijing 100853, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zou, Qianli,Zhao, Hongyou,Zhao, Yuxia,et al. Effective Two-Photon Excited Photodynamic Therapy of Xenograft Tumors Sensitized by Water-Soluble Bis(arylidene)cycloalkanone Photosensitizers[J]. JOURNAL OF MEDICINAL CHEMISTRY,2015,58(20):7949-7958.
APA Zou, Qianli.,Zhao, Hongyou.,Zhao, Yuxia.,Fang, Yanyan.,Chen, Defu.,...&Wu, Feipeng.(2015).Effective Two-Photon Excited Photodynamic Therapy of Xenograft Tumors Sensitized by Water-Soluble Bis(arylidene)cycloalkanone Photosensitizers.JOURNAL OF MEDICINAL CHEMISTRY,58(20),7949-7958.
MLA Zou, Qianli,et al."Effective Two-Photon Excited Photodynamic Therapy of Xenograft Tumors Sensitized by Water-Soluble Bis(arylidene)cycloalkanone Photosensitizers".JOURNAL OF MEDICINAL CHEMISTRY 58.20(2015):7949-7958.
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