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A flavone-based turn-on fluorescent probe for intracellular cysteine/homocysteine sensing with high selectivity
Zhang, Jian1; Lv, Yanlin1; Zhang, Wei2; Ding, Hui1; Liu, Rongji3; Zhao, Yongsheng2; Zhang, Guangjin3; Tian, Zhiyuan1
2016
Source PublicationTALANTA
ISSN0039-9140
Volume146Issue:JANPages:41-48
AbstractA new type of flavone-based fluorescent probe (DMAF) capable of cysteine (Cys)/homocysteine (Hcy) sensing with high selectivity over other amino acids was developed. Such type of probe undergoes Cys/Hcy-mediated cyclization reaction with the involvement of its aldehyde group, which suppresses of the photoinduced electron transfer (PET) process of the probe molecule and consequently leads to the enhancement of fluorescence emission upon excitation using visible light. The formation of product of the Cys/Hcy-mediated cyclization reaction was confirmed and the preliminary fluorescence imaging experiments revealed the biocompatibility of the as-prepared probe and validated its practicability for intracellular Cys/Hcy sensing. (C) 2015 Elsevier B.V. All rights reserved.
KeywordFluorescent Probe Cysteine/homocysteine Bioimaging
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1016/j.talanta.2015.08.025
Indexed BySCI
Language英语
WOS KeywordTOTAL HOMOCYSTEINE ; LIVING CELLS ; CYSTEINE ; THIOLS ; MECHANISMS ; NEUROTOXICITY ; NANOCLUSTERS ; CHEMOSENSORS ; GLUTATHIONE ; ELECTRODE
WOS Research AreaChemistry
WOS SubjectChemistry, Analytical
Funding OrganizationNational Natural Science Foundation of China(21173262 ; "Hundred-Talent Program" of CAS ; 21373218)
WOS IDWOS:000363815600007
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/19763
Collection多相复杂系统国家重点实验室
Affiliation1.UCAS, Sch Chem & Chem Engn, Beijing 100049, PR, Peoples R China
2.Chinese Acad Sci, BNLMS, Inst Chem, Key Lab Photochem, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Key Lab Green Proc & Engn, Beijing Key Lab Ion Liquids Clean Proc, Inst Proc Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Jian,Lv, Yanlin,Zhang, Wei,et al. A flavone-based turn-on fluorescent probe for intracellular cysteine/homocysteine sensing with high selectivity[J]. TALANTA,2016,146(JAN):41-48.
APA Zhang, Jian.,Lv, Yanlin.,Zhang, Wei.,Ding, Hui.,Liu, Rongji.,...&Tian, Zhiyuan.(2016).A flavone-based turn-on fluorescent probe for intracellular cysteine/homocysteine sensing with high selectivity.TALANTA,146(JAN),41-48.
MLA Zhang, Jian,et al."A flavone-based turn-on fluorescent probe for intracellular cysteine/homocysteine sensing with high selectivity".TALANTA 146.JAN(2016):41-48.
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