| Colloidal Gold-Collagen Protein Core-Shell Nanoconjugate: One-Step Biomimetic Synthesis, Layer-by-Layer Assembled Film, and Controlled Cell Growth | |
| Xing, Ruirui1,2,3; Jiao, Tifeng1,2; Yan, Linyin3; Ma, Guanghui3; Liu, Lei4; Dai, Luru5; Li, Junbai5; Moehwald, Helmuth6; Yan, Xuehai3 | |
| 2015-11-11 | |
| Source Publication | ACS APPLIED MATERIALS & INTERFACES
 |
| ISSN | 1944-8244 |
| Volume | 7Issue:44Pages:24733-24740 |
| Abstract | The biogenic synthesis of biomolecule-gold nanoconjugates is of key importance for a broad range of biomedical applications. In this work, a one-step, green, and condition-gentle strategy is presented to synthesize stable colloidal-gold collagen core-shell nanoconjugates in an aqueous solution at room temperature, without use of any reducing agents and stabilizing agents. It is discovered that electrostatic binding between gold ions and collagen proteins and concomitant in situ reduction by hydroxyproline residues are critically responsible for the formation of the core shell nanoconjugates. The film formed by layer-by-layer assembly of such colloidal gold-collagen nanoconjugates can notably improve the mechanical properties and promote cell adhesion, growth, and differentiation. Thus, the colloidal gold-collagen nanoconjugates synthesized by such a straightforward and clean manner, analogous to a biomineralization pathway, provide new alternatives for developing biologically based hybrid biomaterials toward a range of therapeutic and diagnostic applications. |
| Keyword | Collagen Protein Colloidal Gold Nanoparticles Core-shell Nanoconjugates Layer-by-layer Assembly Cell Adhesion And Growth |
| Subtype | Article |
| WOS Headings | Science & Technology ; Technology |
| DOI | 10.1021/acsami.5b07453 |
| Indexed By | SCI |
| Language | 英语 |
| WOS Keyword | ONE-POT SYNTHESIS ; MECHANICAL-PROPERTIES ; METAL NANOPARTICLES ; FUNCTIONALIZATION ; IMMOBILIZATION ; TRANSFECTION ; BIOLOGY |
| WOS Research Area | Science & Technology - Other Topics ; Materials Science |
| WOS Subject | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| Funding Organization | National Natural Science Foundation of China(21522307 ; Talent Fund of the Recruitment Program of Global Youth Experts ; CAS visiting professorships for senior international scientists(2015VTA033) ; Chinese Academy of Sciences (CAS) ; Natural Science Foundation of Hebei Province(B2013203108) ; Science Foundation for the Excellent Youth Scholars from Universities and Colleges of Hebei Province(YQ2013026) ; Support Program for the Top Young Talents of Hebei Province ; 21473208 ; 91434103 ; 21473153) |
| WOS ID | WOS:000364726400041 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/19861 |
| Collection | 生化工程国家重点实验室 |
| Affiliation | 1.Yanshan Univ, State Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Peoples R China 2.Yanshan Univ, Sch Environm & Chem Engn, Hebei Key Lab Appl Chem, Qinhuangdao 066004, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 4.Jiangsu Univ, Inst Adv Mat, Zhenjiang 212013, Jiangsu, Peoples R China 5.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China 6.Max Planck Inst Colloids & Interfaces, D-14476 Potsdam, Germany |
| Recommended Citation GB/T 7714 | Xing, Ruirui,Jiao, Tifeng,Yan, Linyin,et al. Colloidal Gold-Collagen Protein Core-Shell Nanoconjugate: One-Step Biomimetic Synthesis, Layer-by-Layer Assembled Film, and Controlled Cell Growth[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(44):24733-24740. |
| APA | Xing, Ruirui.,Jiao, Tifeng.,Yan, Linyin.,Ma, Guanghui.,Liu, Lei.,...&Yan, Xuehai.(2015).Colloidal Gold-Collagen Protein Core-Shell Nanoconjugate: One-Step Biomimetic Synthesis, Layer-by-Layer Assembled Film, and Controlled Cell Growth.ACS APPLIED MATERIALS & INTERFACES,7(44),24733-24740. |
| MLA | Xing, Ruirui,et al."Colloidal Gold-Collagen Protein Core-Shell Nanoconjugate: One-Step Biomimetic Synthesis, Layer-by-Layer Assembled Film, and Controlled Cell Growth".ACS APPLIED MATERIALS & INTERFACES 7.44(2015):24733-24740. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Colloidal Gold-Colla（4966KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | Application Full Text | |
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