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Colloidal Gold-Collagen Protein Core-Shell Nanoconjugate: One-Step Biomimetic Synthesis, Layer-by-Layer Assembled Film, and Controlled Cell Growth
Xing, Ruirui1,2,3; Jiao, Tifeng1,2; Yan, Linyin3; Ma, Guanghui3; Liu, Lei4; Dai, Luru5; Li, Junbai5; Moehwald, Helmuth6; Yan, Xuehai3
2015-11-11
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume7Issue:44Pages:24733-24740
AbstractThe biogenic synthesis of biomolecule-gold nanoconjugates is of key importance for a broad range of biomedical applications. In this work, a one-step, green, and condition-gentle strategy is presented to synthesize stable colloidal-gold collagen core-shell nanoconjugates in an aqueous solution at room temperature, without use of any reducing agents and stabilizing agents. It is discovered that electrostatic binding between gold ions and collagen proteins and concomitant in situ reduction by hydroxyproline residues are critically responsible for the formation of the core shell nanoconjugates. The film formed by layer-by-layer assembly of such colloidal gold-collagen nanoconjugates can notably improve the mechanical properties and promote cell adhesion, growth, and differentiation. Thus, the colloidal gold-collagen nanoconjugates synthesized by such a straightforward and clean manner, analogous to a biomineralization pathway, provide new alternatives for developing biologically based hybrid biomaterials toward a range of therapeutic and diagnostic applications.
KeywordCollagen Protein Colloidal Gold Nanoparticles Core-shell Nanoconjugates Layer-by-layer Assembly Cell Adhesion And Growth
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
DOI10.1021/acsami.5b07453
Indexed BySCI
Language英语
WOS KeywordONE-POT SYNTHESIS ; MECHANICAL-PROPERTIES ; METAL NANOPARTICLES ; FUNCTIONALIZATION ; IMMOBILIZATION ; TRANSFECTION ; BIOLOGY
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China(21522307 ; Talent Fund of the Recruitment Program of Global Youth Experts ; CAS visiting professorships for senior international scientists(2015VTA033) ; Chinese Academy of Sciences (CAS) ; Natural Science Foundation of Hebei Province(B2013203108) ; Science Foundation for the Excellent Youth Scholars from Universities and Colleges of Hebei Province(YQ2013026) ; Support Program for the Top Young Talents of Hebei Province ; 21473208 ; 91434103 ; 21473153)
WOS IDWOS:000364726400041
Citation statistics
Cited Times:46[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/19861
Collection生化工程国家重点实验室
Affiliation1.Yanshan Univ, State Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Peoples R China
2.Yanshan Univ, Sch Environm & Chem Engn, Hebei Key Lab Appl Chem, Qinhuangdao 066004, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
4.Jiangsu Univ, Inst Adv Mat, Zhenjiang 212013, Jiangsu, Peoples R China
5.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China
6.Max Planck Inst Colloids & Interfaces, D-14476 Potsdam, Germany
Recommended Citation
GB/T 7714
Xing, Ruirui,Jiao, Tifeng,Yan, Linyin,et al. Colloidal Gold-Collagen Protein Core-Shell Nanoconjugate: One-Step Biomimetic Synthesis, Layer-by-Layer Assembled Film, and Controlled Cell Growth[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(44):24733-24740.
APA Xing, Ruirui.,Jiao, Tifeng.,Yan, Linyin.,Ma, Guanghui.,Liu, Lei.,...&Yan, Xuehai.(2015).Colloidal Gold-Collagen Protein Core-Shell Nanoconjugate: One-Step Biomimetic Synthesis, Layer-by-Layer Assembled Film, and Controlled Cell Growth.ACS APPLIED MATERIALS & INTERFACES,7(44),24733-24740.
MLA Xing, Ruirui,et al."Colloidal Gold-Collagen Protein Core-Shell Nanoconjugate: One-Step Biomimetic Synthesis, Layer-by-Layer Assembled Film, and Controlled Cell Growth".ACS APPLIED MATERIALS & INTERFACES 7.44(2015):24733-24740.
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