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Exploration of graphene oxide as an intelligent platform for cancer vaccines
Yue, Hua1; Wei, Wei1; Gu, Zonglin2,3,4; Ni, Dezhi1; Luo, Nana1; Yang, Zaixing2,3,4; Zhao, Lin2,3,4; Garate, Jose Antonio5; Zhou, Ruhong2,3,4,5,6; Su, Zhiguo1,7; Ma, Guanghui1,7
2015
Source PublicationNANOSCALE
ISSN2040-3364
Volume7Issue:47Pages:19949-19957
Abstract

We explored an intelligent vaccine system via facile approaches using both experimental and theoretical techniques based on the two-dimensional graphene oxide (GO). Without extra addition of bio/chemical stimulators, the microsized GO imparted various immune activation tactics to improve the antigen immunogenicity. A high antigen adsorption was acquired, and the mechanism was revealed to be a combination of electrostatic, hydrophobic, and p-p stacking interactions. The "folding GO" acted as a cytokine self-producer and antigen reservoir and showed a particular autophagy, which efficiently promoted the activation of antigen presenting cells (APCs) and subsequent antigen cross-presentation. Such a "One but All" modality thus induced a high level of anti-tumor responses in a programmable way and resulted in efficient tumor regression in vivo. This work may shed light on the potential use of a new dimensional nano-platform in the development of high-performance cancer vaccines.

SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
DOI10.1039/c5nr04986e
Indexed BySCI
Language英语
WOS KeywordCELLS IN-SITU ; DRUG-DELIVERY ; NANOPARTICLES ; AUTOPHAGY ; NANOSHEETS ; DIAGNOSIS ; THERAPY ; BINDING
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
Funding OrganizationYouth Innovation Promotion Association, CAS(2013033) ; 973 Program(2013CB531500) ; National High Technology Research and Development Program of China(2014AA093604) ; National Natural Science Foundation of China(51302265 ; Ministry of Science and Technology of China(2014ZX09102045) ; IBM Blue Gene Science Program - Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; 11374221)
WOS IDWOS:000365530700013
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/19889
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Natl Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
2.Soochow Univ, Inst Quantitat Biol & Med, SRMP, Suzhou 215123, Peoples R China
3.Soochow Univ, RAD X, Collaborat Innovat Ctr Radiat Med, Jiangsu Higher Educ Inst, Suzhou 215123, Peoples R China
4.Soochow Univ, Jiangsu Prov Key Lab Radiat Med & Protect, Suzhou 215123, Peoples R China
5.IBM Thomas J Watson Res Ctr, Computat Biol Ctr, Yorktown Hts, NY 10598 USA
6.Columbia Univ, Dept Chem, New York, NY 10027 USA
7.Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300072, Peoples R China
Recommended Citation
GB/T 7714
Yue, Hua,Wei, Wei,Gu, Zonglin,et al. Exploration of graphene oxide as an intelligent platform for cancer vaccines[J]. NANOSCALE,2015,7(47):19949-19957.
APA Yue, Hua.,Wei, Wei.,Gu, Zonglin.,Ni, Dezhi.,Luo, Nana.,...&Ma, Guanghui.(2015).Exploration of graphene oxide as an intelligent platform for cancer vaccines.NANOSCALE,7(47),19949-19957.
MLA Yue, Hua,et al."Exploration of graphene oxide as an intelligent platform for cancer vaccines".NANOSCALE 7.47(2015):19949-19957.
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