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Chitosan-based mucosal adjuvants: Sunrise on the ocean
Xia, Yufei1,2; Fan, Qingze1,2; Hao, Dongxia1; Wu, Jie1; Ma, Guanghui1; Su, Zhiguo1
2015-11-04
Source PublicationVACCINE
ISSN0264-410X
Volume33Issue:44Pages:5997-6010
AbstractMucosal vaccination, which is shown to elicit systemic and mucosal immune responses, serves as a non-invasive and convenient alternative to parenteral administration, with stronger capability in combatting diseases at the site of entry. The exploration of potent mucosal adjuvants is emerging as a significant area, based on the continued necessity to amplify the immune responses to a wide array of antigens that are poorly immunogenic at the mucosal sites. As one of the inspirations from the ocean, chitosan-based mucosal adjuvants have been developed with unique advantages, such as, ability of mucosal adhesion, distinct trait of opening the junctions to allow the paracellular transport of antigen, good tolerability and biocompatibility, which guaranteed the great potential in capitalizing on their application in human clinical trials. In this review, the state of art of chitosan and its derivatives as mucosal adjuvants, including thermo-sensitive chitosan system as mucosal adjuvant that were newly developed by author's group, was described, as well as the clinical application perspective. After a brief introduction of mucosal adjuvants, chitosan and its derivatives as robust immune potentiator were discussed in detail and depth, in regard to the metabolism, safety profile, mode of actions and preclinical and clinical applications, which may shed light on the massive clinical application of chitosan as mucosal adjuvant. (C) 2015 Elsevier Ltd. All rights reserved.
KeywordChitosan Adjuvant Mucosal Immunity Marine Drug Clinical Application
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.vaccine.2015.07.101
Indexed BySCI
Language英语
WOS KeywordSTREPTOCOCCUS-PNEUMONIAE INFECTION ; PARTICULATE VACCINE ADJUVANTS ; ACIDIC MAMMALIAN CHITINASE ; THERMAL-SENSITIVE HYDROGEL ; EPITHELIAL-CELLS CACO-2 ; IN-VITRO PERMEABILITY ; NASAL DRUG-DELIVERY ; INFLUENZA VACCINE ; DENDRITIC CELLS ; MOLECULAR-WEIGHT
WOS Research AreaImmunology ; Research & Experimental Medicine
WOS SubjectImmunology ; Medicine, Research & Experimental
Funding OrganizationNational Key Basic Research Program of China (973 Program)(2013CB531505) ; National Science and Technology Major Project(2014ZX09102045) ; National High Technology Research and Development Program of China(2014AA093604)
WOS IDWOS:000365365700016
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/19893
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Xia, Yufei,Fan, Qingze,Hao, Dongxia,et al. Chitosan-based mucosal adjuvants: Sunrise on the ocean[J]. VACCINE,2015,33(44):5997-6010.
APA Xia, Yufei,Fan, Qingze,Hao, Dongxia,Wu, Jie,Ma, Guanghui,&Su, Zhiguo.(2015).Chitosan-based mucosal adjuvants: Sunrise on the ocean.VACCINE,33(44),5997-6010.
MLA Xia, Yufei,et al."Chitosan-based mucosal adjuvants: Sunrise on the ocean".VACCINE 33.44(2015):5997-6010.
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