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Polymeric micro/nanoparticles: Particle design and potential vaccine delivery applications
Yue, Hua1; Ma, Guanghui1,2
2015-11-04
Source PublicationVACCINE
ISSN0264-410X
Volume33Issue:44Pages:5927-5936
AbstractParticle based adjuvant showed promising signs on delivering antigen to immune cells and acting as stimulators to elicit preventive or therapeutic response. Nevertheless, the wide size distribution of available polymeric particles has so far obscured the immunostimulative effects of particle adjuvant, and compromised the progress in pharmacological researches. To conquer this hurdle, our research group has carried out a series of researches regarding the particulate vaccine, by taking advantage of the successful fabrication of polymeric particles with uniform size. In this review, we highlight the insight and practical progress focused on the effects of physiochemical property (e.g. particle size, charge, hydrophobicity, surface chemical group, and particle shape) and antigen loading mode on the resultant biological/immunological outcome. The underlying mechanisms of how the particles-based vaccine functioned in the immune system are also discussed. Based on the knowledge, particles with high antigen payload and optimized attributes could be designed for expected adjuvant purpose, leading to the development of high efficient vaccine candidates. (C) 2015 Elsevier Ltd. All rights reserved.
KeywordMicro/nanoparticles Adjuvant Physiochemical Property Preventive/therapeutic Vaccine Antigen Loading Immunological Mechanism
SubtypeReview
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.vaccine.2015.07.100
Indexed BySCI
Language英语
WOS KeywordMEMBRANE EMULSIFICATION TECHNIQUE ; THERAPEUTIC CANCER VACCINES ; T-CELL RESPONSES ; IMMUNE-RESPONSES ; DRUG-DELIVERY ; NANOPARTICLE VACCINES ; BIODEGRADABLE NANOPARTICLES ; CHITOSAN MICROSPHERES ; COMPLEMENT ACTIVATION ; SENSITIVE HYDROGEL
WOS Research AreaImmunology ; Research & Experimental Medicine
WOS SubjectImmunology ; Medicine, Research & Experimental
Funding OrganizationYouth Innovation Promotion Association ; Chinese Academy of Sciences(2013033) ; National Natural Science Foundation of China(51302265) ; National High Technology Research and Development Program of China(2014AA093604) ; Major Project of the Ministry of Science and Technology of China(2014ZX09102045)
WOS IDWOS:000365365700007
Citation statistics
Cited Times:36[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/19904
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300072, Peoples R China
Recommended Citation
GB/T 7714
Yue, Hua,Ma, Guanghui. Polymeric micro/nanoparticles: Particle design and potential vaccine delivery applications[J]. VACCINE,2015,33(44):5927-5936.
APA Yue, Hua,&Ma, Guanghui.(2015).Polymeric micro/nanoparticles: Particle design and potential vaccine delivery applications.VACCINE,33(44),5927-5936.
MLA Yue, Hua,et al."Polymeric micro/nanoparticles: Particle design and potential vaccine delivery applications".VACCINE 33.44(2015):5927-5936.
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