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One-Step Nanoengineering of Hydrophobic Photosensitive Drugs for the Photodynamic Therapy
Zhou, Chao1,2; Abbas, Manzar2; Zhang, Min3; Zou, Qianli2; Shen, Guizhi2; Chen, Chengjun2; Peng, Hongshang1; Yan, Xuehai2
2015-12-01
Source PublicationJOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
ISSN1533-4880
Volume15Issue:12Pages:10141-10148
AbstractNanoengineering of anticancer therapeutic drugs including photosensitizers is highly desired and extremely required for improved therapeutic efficacy. It remains a formidable challenge to achieve nanostructured colloidal particles directly starting from hydrophobic drugs due to their hydrophobic nature and ready aggregation in aqueous ambient. In this work, we report a facile method for a one-pot preparation of hydrophobic photosensitizer nanoparticles by coating with different types of polyelectrolyte as stabilizing agents. Regardless of negatively or positively charged polyelectrolyte used, including Poly-L-lysine (PLL, MW = 15 k-30 k), PLL (MW = 30 k-70 k), heparin, and hyaluronic acid (HA), the hydrophobic photosensitizer BDEA (2,5-Bis(4-(diethylamino)benzylidene)cyclopentanone) as a model drug can be readily manipulated into stable and well-dispersed nanoparticles with size of average 120 nm. Stabilization presumably contributes to electrostatic repulsion of the adsorbed polyelectrolyte layer onto nanoparticles. Their anticancer activity against the HeLa cell line shows that the endocytic internalization of these nanosystems is associated with antiproliferative effects after irradiation with visible light. The one-step preparation strategy may be an alternative approach for the design of nano-formulations of hydrophobic photosensitive drugs, presenting a potential for photodynamic antitumor therapy.
KeywordHydrophobic Photosensitizers Nanoparticles Polyelectrolyte Coating Drug Delivery Photodynamic Therapy
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
DOI10.1166/jnn.2015.11695
Indexed BySCI
Language英语
WOS Keyword2-PHOTON ABSORPTION ; CANCER ; PORPHYRIN ; DELIVERY ; MICROCAPSULES ; NANOPARTICLES ; NANOSHELLS ; STRATEGIES ; SPHERES ; DESIGN
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
Funding OrganizationNational Natural Science Foundation of China(21473208 ; Talent Fund of Recruitment Program of Global Youth Experts, Beijing Natural Science Foundation(7154220) ; Chinese Academy of Sciences (CAS) ; CAS visiting professorships for senior international scientists(2015VTA033) ; 51403214 ; 91434103 ; 81402871)
WOS IDWOS:000365555000108
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/19905
Collection生化工程国家重点实验室
Affiliation1.Beijing Jiaotong Univ, Inst Optoelect Technol, Key Lab Luminescence & Opt Informat, Minist Educ, Beijing 100044, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.China Food & Drug Adm, Ctr Drug Evaluat, Beijing 100038, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Chao,Abbas, Manzar,Zhang, Min,et al. One-Step Nanoengineering of Hydrophobic Photosensitive Drugs for the Photodynamic Therapy[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2015,15(12):10141-10148.
APA Zhou, Chao.,Abbas, Manzar.,Zhang, Min.,Zou, Qianli.,Shen, Guizhi.,...&Yan, Xuehai.(2015).One-Step Nanoengineering of Hydrophobic Photosensitive Drugs for the Photodynamic Therapy.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,15(12),10141-10148.
MLA Zhou, Chao,et al."One-Step Nanoengineering of Hydrophobic Photosensitive Drugs for the Photodynamic Therapy".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 15.12(2015):10141-10148.
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