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Alpha-tocopherol quinine ameliorates spatial memory deficits by reducing beta-amyloid oligomers, neuroinflammation and oxidative stress in transgenic mice with Alzheimer's disease
Wang, Shao-wei1; Yang, Shi-gao1; Liu, Wen1,2; Zhang, Yang-xin1,2; Xu, Peng-xin1,3; Wang, Teng1,2; Ling, Tie-jun4; Liu, Rui-tian1
2016
发表期刊BEHAVIOURAL BRAIN RESEARCH
ISSN0166-4328
卷号296期号:JAN页码:109-117
摘要The pathologies of Alzheimer's disease (AD) is associated with soluble beta-amyloid (A beta) oligomers, neuroinflammation and oxidative stress. Decreasing the levels of A beta oligomer, glial activation and oxidative stress are potential therapeutic approaches for AD treatment. We previously found alpha-tocopherol quinine (alpha-TQ) inhibited Ap aggregation and cytotoxicity, decreased the release of inflammatory cytokines and reactive oxygen species (ROS) in vitro. However, whether alpha-TQameliorates memory deficits and other neuropathologies in mice or patients with AD remains unknown. In this study, we reported that orally administered a-TQ ameliorated memory impairment in APPswe/PS1dE9 transgenic mice, decreased oxidative stress and the levels of A beta oligomer in the brains of mice, prevented the production of inducible nitric oxide synthase and inflammatory mediators, such as interleukin-6 and interleukin-1 beta, and inhibited microglial activation by inhibiting NF-kappa B signaling pathway. These findings suggest that alpha-TQ has potential therapeutic value for AD treatment. (C) 2015 Elsevier B.V. All rights reserved.
关键词Rrr-alpha-tocopherol Quinine Alzheimer's Disease Beta-amyloid Oligomer Neuroinflammation Nf-kappa b Signaling Oxidative Stress
文章类型Article
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1016/j.bbr.2015.09.003
收录类别SCI
语种英语
关键词[WOS]NF-KAPPA-B ; NEURODEGENERATIVE DISEASE ; IN-VIVO ; FIBRILS ; QUINONE ; CONFORMATION ; INFLAMMATION ; SUPEROXIDE ; PROTEIN ; MITOCHONDRIA
WOS研究方向Behavioral Sciences ; Neurosciences & Neurology
WOS类目Behavioral Sciences ; Neurosciences
项目资助者National Natural Science Foundation of China(81171014 ; National Science and Technology Major Projects of New Drugs(2012ZX09103301-001 ; 31471720 ; 2014ZX09102045-006) ; 31101335)
WOS记录号WOS:000366079100015
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/20144
专题生化工程国家重点实验室
作者单位1.Chinese Acad Sci, Natl Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
2.Anhui Agr Univ, Sch Life Sci, Hefei 230036, Peoples R China
3.Ningxia Univ, Sch Life Sci, Yinchuan 750021, Peoples R China
4.Anhui Agr Univ, State Key Lab Tea Plant Biol & Utilizat, Hefei 230036, Peoples R China
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Wang, Shao-wei,Yang, Shi-gao,Liu, Wen,et al. Alpha-tocopherol quinine ameliorates spatial memory deficits by reducing beta-amyloid oligomers, neuroinflammation and oxidative stress in transgenic mice with Alzheimer's disease[J]. BEHAVIOURAL BRAIN RESEARCH,2016,296(JAN):109-117.
APA Wang, Shao-wei.,Yang, Shi-gao.,Liu, Wen.,Zhang, Yang-xin.,Xu, Peng-xin.,...&Liu, Rui-tian.(2016).Alpha-tocopherol quinine ameliorates spatial memory deficits by reducing beta-amyloid oligomers, neuroinflammation and oxidative stress in transgenic mice with Alzheimer's disease.BEHAVIOURAL BRAIN RESEARCH,296(JAN),109-117.
MLA Wang, Shao-wei,et al."Alpha-tocopherol quinine ameliorates spatial memory deficits by reducing beta-amyloid oligomers, neuroinflammation and oxidative stress in transgenic mice with Alzheimer's disease".BEHAVIOURAL BRAIN RESEARCH 296.JAN(2016):109-117.
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