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Efficient Recovery of Penicillin G by a Hydrophobic Ionic Liquid
Liu, Qingfen; Li, Yingbo; Li, Wangliang; Liang, Xiangfeng; Zhang, Chao; Liu, Huizhou
2016-02-01
Source PublicationACS SUSTAINABLE CHEMISTRY & ENGINEERING
ISSN2168-0485
Volume4Issue:2Pages:609-615
AbstractPenicillin G is a widely used antibiotic, but the traditional volatile organic solvent extraction causes serious environmental problems. In this work, a hydrophobic ionic liquid ([Bmim]PF6) was developed as a new extraction agent for recovery of penicillin G from aqueous solutions. The extraction efficiency and the partition coefficient of penicillin G were used as the indexes to evaluate the IL extraction ability. Key factors affecting the effectiveness of recovery, such as the pH of the aqueous solution, the initial concentration of penicillin G, and the IL-to-aqueous solution volume ratio, were investigated to determine the optimal conditions. The results showed that the pH of the aqueous phase strongly influenced the success of the extraction. The optimal pH value, phase ratio, and penicillin concentration were 1.5-2.0, 1.5/1 to 2.0/ 1, and 3.00-5.00 X 10(4) units/mL, respectively, whereby the partition coefficient and extraction efficiency were more than 30 and 91%, respectively. The extraction mechanism was explored by analyzing the chemical bonds using spectrographic analysis. Preliminary results indicated that penicillin G can be effectively extracted from fermentation broth by [Bmim]PF6 with extraction efficiencies of >87%. In addition, a higher selectivity and a much lower extent of emulsification were achieved by [Bmim]PF6 compared to those of butyl acetate. It demonstrates that the IL-based extraction strategy developed in this work is promising and effective, and as a result, the development of an IL-based extraction process for the recovery of penicillin G is straightforwardly envisaged.
KeywordPenicillin g Ionic Liquids Liquid-liquid Extraction Partition Coefficient Mechanism
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
DOI10.1021/acssuschemeng.5b00975
Indexed BySCI
Language英语
WOS KeywordAQUEOUS 2-PHASE SYSTEM ; BETA-LACTAM ANTIBIOTICS ; FERMENTATION BROTH ; EXTRACTION ; SEPARATION ; SOLVENTS
WOS Research AreaChemistry ; Engineering
WOS SubjectChemistry, Multidisciplinary ; Engineering, Chemical
Funding OrganizationNational Science Fund of China(21136009 ; 21506221)
WOS IDWOS:000369347800029
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/20612
Collection湿法冶金清洁生产技术国家工程实验室
AffiliationChinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, 1 BeiErJie, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Liu, Qingfen,Li, Yingbo,Li, Wangliang,et al. Efficient Recovery of Penicillin G by a Hydrophobic Ionic Liquid[J]. ACS SUSTAINABLE CHEMISTRY & ENGINEERING,2016,4(2):609-615.
APA Liu, Qingfen,Li, Yingbo,Li, Wangliang,Liang, Xiangfeng,Zhang, Chao,&Liu, Huizhou.(2016).Efficient Recovery of Penicillin G by a Hydrophobic Ionic Liquid.ACS SUSTAINABLE CHEMISTRY & ENGINEERING,4(2),609-615.
MLA Liu, Qingfen,et al."Efficient Recovery of Penicillin G by a Hydrophobic Ionic Liquid".ACS SUSTAINABLE CHEMISTRY & ENGINEERING 4.2(2016):609-615.
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