Efficient Recovery of Penicillin G by a Hydrophobic Ionic Liquid
Liu, Qingfen; Li, Yingbo; Li, Wangliang; Liang, Xiangfeng; Zhang, Chao; Liu, Huizhou
2016-02-01
发表期刊ACS SUSTAINABLE CHEMISTRY & ENGINEERING
ISSN2168-0485
卷号4期号:2页码:609-615
摘要Penicillin G is a widely used antibiotic, but the traditional volatile organic solvent extraction causes serious environmental problems. In this work, a hydrophobic ionic liquid ([Bmim]PF6) was developed as a new extraction agent for recovery of penicillin G from aqueous solutions. The extraction efficiency and the partition coefficient of penicillin G were used as the indexes to evaluate the IL extraction ability. Key factors affecting the effectiveness of recovery, such as the pH of the aqueous solution, the initial concentration of penicillin G, and the IL-to-aqueous solution volume ratio, were investigated to determine the optimal conditions. The results showed that the pH of the aqueous phase strongly influenced the success of the extraction. The optimal pH value, phase ratio, and penicillin concentration were 1.5-2.0, 1.5/1 to 2.0/ 1, and 3.00-5.00 X 10(4) units/mL, respectively, whereby the partition coefficient and extraction efficiency were more than 30 and 91%, respectively. The extraction mechanism was explored by analyzing the chemical bonds using spectrographic analysis. Preliminary results indicated that penicillin G can be effectively extracted from fermentation broth by [Bmim]PF6 with extraction efficiencies of >87%. In addition, a higher selectivity and a much lower extent of emulsification were achieved by [Bmim]PF6 compared to those of butyl acetate. It demonstrates that the IL-based extraction strategy developed in this work is promising and effective, and as a result, the development of an IL-based extraction process for the recovery of penicillin G is straightforwardly envisaged.
关键词Penicillin g Ionic Liquids Liquid-liquid Extraction Partition Coefficient Mechanism
文章类型Article
WOS标题词Science & Technology ; Physical Sciences ; Technology
DOI10.1021/acssuschemeng.5b00975
收录类别SCI
语种英语
关键词[WOS]AQUEOUS 2-PHASE SYSTEM ; BETA-LACTAM ANTIBIOTICS ; FERMENTATION BROTH ; EXTRACTION ; SEPARATION ; SOLVENTS
WOS研究方向Chemistry ; Engineering
WOS类目Chemistry, Multidisciplinary ; Engineering, Chemical
项目资助者National Science Fund of China(21136009 ; 21506221)
WOS记录号WOS:000369347800029
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/20612
专题湿法冶金清洁生产技术国家工程实验室
作者单位Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, 1 BeiErJie, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714
Liu, Qingfen,Li, Yingbo,Li, Wangliang,et al. Efficient Recovery of Penicillin G by a Hydrophobic Ionic Liquid[J]. ACS SUSTAINABLE CHEMISTRY & ENGINEERING,2016,4(2):609-615.
APA Liu, Qingfen,Li, Yingbo,Li, Wangliang,Liang, Xiangfeng,Zhang, Chao,&Liu, Huizhou.(2016).Efficient Recovery of Penicillin G by a Hydrophobic Ionic Liquid.ACS SUSTAINABLE CHEMISTRY & ENGINEERING,4(2),609-615.
MLA Liu, Qingfen,et al."Efficient Recovery of Penicillin G by a Hydrophobic Ionic Liquid".ACS SUSTAINABLE CHEMISTRY & ENGINEERING 4.2(2016):609-615.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Efficient Recovery o(4479KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Liu, Qingfen]的文章
[Li, Yingbo]的文章
[Li, Wangliang]的文章
百度学术
百度学术中相似的文章
[Liu, Qingfen]的文章
[Li, Yingbo]的文章
[Li, Wangliang]的文章
必应学术
必应学术中相似的文章
[Liu, Qingfen]的文章
[Li, Yingbo]的文章
[Li, Wangliang]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Efficient Recovery of Penicillin G by a Hydrophobic Ionic Liquid.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。