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Trace Solvent as a Predominant Factor To Tune Dipeptide Self-Assembly
Wang, Juan1,2; Liu, Kai1,2,3; Yan, Linyin1,2; Wang, Anhe1; Bai, Shuo1; Yan, Xuehai1,2
Source PublicationACS NANO

Solvent molecules such as water are of key importance for tuning self-assembly in biological systems. However, it remains a great challenge to detect the role of different types of noncovalent interactions between trace solvents and biomolecules such as peptides. In this work, we discover a dominant role of trace amounts of solvents for mediation of dipeptide self-assembly, in which solvent-bridged hydrogen bonding is demonstrated as a crucial force in directing fiber formation. Hydrogen-bond-forming solvents (including ethanol, N,N-dimethylformamide, and acetone) can affect the hydrogen bonding of C=O and N-H in diphenylalanine (FF) molecules with themselves, but this does not induce pi-pi stacking between FF molecules. The directional hydrogen bonding promotes a long-range-ordered arrangement of FF molecules, preferentially along one dimension to form nanofibers or nanobelts. Furthermore, we demonstrate that water with strong hydrogen-bond-forming capability can notably speed up structure formation with long-range order, revealing the importance of water as a trace solvent for regulation of persistent and robust fiber formation.

KeywordDipeptide Self-assembly Trace Solvent Fibers Hydrogen Bonding
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
Indexed BySCI
WOS KeywordPeptide-based Materials ; Diphenylalanine Peptide ; Structural Transition ; Nanotubes ; Water ; Simulations ; Amphiphiles ; Nanostructures ; Microtubes ; Nanofibers
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China(21522307 ; Talent Fund of the Recruitment Program of Global Youth Experts ; CAS(2015VTA033) ; Chinese Academy of Sciences (CAS) ; 21473208 ; 91434103)
WOS IDWOS:000370987400051
Citation statistics
Cited Times:88[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorYan, Xuehai
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Ctr Mesosci, Inst Proc Engn, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Wang, Juan,Liu, Kai,Yan, Linyin,et al. Trace Solvent as a Predominant Factor To Tune Dipeptide Self-Assembly[J]. ACS NANO,2016,10(2):2138-2143.
APA Wang, Juan,Liu, Kai,Yan, Linyin,Wang, Anhe,Bai, Shuo,&Yan, Xuehai.(2016).Trace Solvent as a Predominant Factor To Tune Dipeptide Self-Assembly.ACS NANO,10(2),2138-2143.
MLA Wang, Juan,et al."Trace Solvent as a Predominant Factor To Tune Dipeptide Self-Assembly".ACS NANO 10.2(2016):2138-2143.
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