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Simple Peptide-Tuned Self-Assembly of Photosensitizers towards Anticancer Photodynamic Therapy
Liu, Kai1,2; Xing, Ruirui1; Zou, Qianli1,3; Ma, Guanghui1; Mohwald, Helmuth3; Yan, Xuehai1
2016-02-24
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
Volume55Issue:9Pages:3036-3039
Abstract

Peptide-tuned self-assembly of functional components offers a strategy towards improved properties and unique functions of materials, but the requirement of many different functions and a lack of understanding of complex structures present a high barrier for applications. Herein, we report a photosensitive drug delivery system for photodynamic therapy (PDT) by a simple dipeptide- or amphiphilic amino-acid-tuned self-assembly of photosensitizers (PSs). The assembled nanodrugs exhibit multiple favorable therapeutic features, including tunable size, high loading efficiency, and on-demand drug release responding to pH, surfactant, and enzyme stimuli, as well as preferable cellular uptake and biodistribution. These features result in greatly enhanced PDT efficacy invitro and invivo, leading to almost complete tumor eradication in mice receiving a single drug dose and a single exposure to light.

KeywordCooperative Self-assembly Nanodrugs Peptides Photodynamic Therapy Photosensitizers
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1002/anie.201509810
Indexed BySCI
Language英语
WOS KeywordCancer-treatment ; In-vitro ; Nanoparticles ; Delivery ; Agents ; Internalization ; Porphyrins ; Efficiency ; Systems ; Glycol
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China(21522307 ; Talent Fund of the Recruitment Program of Global Youth Experts ; CAS visiting professorships for senior international scientists(2015VTA033) ; Chinese Academy of Sciences (CAS) ; German Max-Planck Society ; 21473208 ; 91434103 ; 51403214)
WOS IDWOS:000370656200008
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/20625
Collection研究所(批量导入)
Corresponding AuthorYan, Xuehai
Affiliation1.Chinese Acad Sci, Natl Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Max Planck Inst Colloids & Interfaces, Muhlenberg 1, D-14476 Potsdam, Germany
Recommended Citation
GB/T 7714
Liu, Kai,Xing, Ruirui,Zou, Qianli,et al. Simple Peptide-Tuned Self-Assembly of Photosensitizers towards Anticancer Photodynamic Therapy[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2016,55(9):3036-3039.
APA Liu, Kai,Xing, Ruirui,Zou, Qianli,Ma, Guanghui,Mohwald, Helmuth,&Yan, Xuehai.(2016).Simple Peptide-Tuned Self-Assembly of Photosensitizers towards Anticancer Photodynamic Therapy.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,55(9),3036-3039.
MLA Liu, Kai,et al."Simple Peptide-Tuned Self-Assembly of Photosensitizers towards Anticancer Photodynamic Therapy".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 55.9(2016):3036-3039.
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