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Simple Peptide-Tuned Self-Assembly of Photosensitizers towards Anticancer Photodynamic Therapy | |
Liu, Kai1,2; Xing, Ruirui1; Zou, Qianli1,3; Ma, Guanghui1; Mohwald, Helmuth3; Yan, Xuehai1 | |
2016-02-24 | |
Source Publication | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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ISSN | 1433-7851 |
Volume | 55Issue:9Pages:3036-3039 |
Abstract | Peptide-tuned self-assembly of functional components offers a strategy towards improved properties and unique functions of materials, but the requirement of many different functions and a lack of understanding of complex structures present a high barrier for applications. Herein, we report a photosensitive drug delivery system for photodynamic therapy (PDT) by a simple dipeptide- or amphiphilic amino-acid-tuned self-assembly of photosensitizers (PSs). The assembled nanodrugs exhibit multiple favorable therapeutic features, including tunable size, high loading efficiency, and on-demand drug release responding to pH, surfactant, and enzyme stimuli, as well as preferable cellular uptake and biodistribution. These features result in greatly enhanced PDT efficacy invitro and invivo, leading to almost complete tumor eradication in mice receiving a single drug dose and a single exposure to light. |
Keyword | Cooperative Self-assembly Nanodrugs Peptides Photodynamic Therapy Photosensitizers |
Subtype | Article |
WOS Headings | Science & Technology ; Physical Sciences |
DOI | 10.1002/anie.201509810 |
Indexed By | SCI |
Language | 英语 |
WOS Keyword | Cancer-treatment ; In-vitro ; Nanoparticles ; Delivery ; Agents ; Internalization ; Porphyrins ; Efficiency ; Systems ; Glycol |
WOS Research Area | Chemistry |
WOS Subject | Chemistry, Multidisciplinary |
Funding Organization | National Natural Science Foundation of China(21522307 ; Talent Fund of the Recruitment Program of Global Youth Experts ; CAS visiting professorships for senior international scientists(2015VTA033) ; Chinese Academy of Sciences (CAS) ; German Max-Planck Society ; 21473208 ; 91434103 ; 51403214) |
WOS ID | WOS:000370656200008 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.ipe.ac.cn/handle/122111/20625 |
Collection | 研究所(批量导入) |
Corresponding Author | Yan, Xuehai |
Affiliation | 1.Chinese Acad Sci, Natl Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Max Planck Inst Colloids & Interfaces, Muhlenberg 1, D-14476 Potsdam, Germany |
Recommended Citation GB/T 7714 | Liu, Kai,Xing, Ruirui,Zou, Qianli,et al. Simple Peptide-Tuned Self-Assembly of Photosensitizers towards Anticancer Photodynamic Therapy[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2016,55(9):3036-3039. |
APA | Liu, Kai,Xing, Ruirui,Zou, Qianli,Ma, Guanghui,Mohwald, Helmuth,&Yan, Xuehai.(2016).Simple Peptide-Tuned Self-Assembly of Photosensitizers towards Anticancer Photodynamic Therapy.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,55(9),3036-3039. |
MLA | Liu, Kai,et al."Simple Peptide-Tuned Self-Assembly of Photosensitizers towards Anticancer Photodynamic Therapy".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 55.9(2016):3036-3039. |
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Liu_et_al-2016-Angew(2079KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | Application Full Text |
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