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Simple Peptide-Tuned Self-Assembly of Photosensitizers towards Anticancer Photodynamic Therapy
Liu, Kai1,2; Xing, Ruirui1; Zou, Qianli1,3; Ma, Guanghui1; Mohwald, Helmuth3; Yan, Xuehai1
2016-02-24
发表期刊ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
卷号55期号:9页码:3036-3039
摘要

Peptide-tuned self-assembly of functional components offers a strategy towards improved properties and unique functions of materials, but the requirement of many different functions and a lack of understanding of complex structures present a high barrier for applications. Herein, we report a photosensitive drug delivery system for photodynamic therapy (PDT) by a simple dipeptide- or amphiphilic amino-acid-tuned self-assembly of photosensitizers (PSs). The assembled nanodrugs exhibit multiple favorable therapeutic features, including tunable size, high loading efficiency, and on-demand drug release responding to pH, surfactant, and enzyme stimuli, as well as preferable cellular uptake and biodistribution. These features result in greatly enhanced PDT efficacy invitro and invivo, leading to almost complete tumor eradication in mice receiving a single drug dose and a single exposure to light.

关键词Cooperative Self-assembly Nanodrugs Peptides Photodynamic Therapy Photosensitizers
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
DOI10.1002/anie.201509810
收录类别SCI
语种英语
关键词[WOS]Cancer-treatment ; In-vitro ; Nanoparticles ; Delivery ; Agents ; Internalization ; Porphyrins ; Efficiency ; Systems ; Glycol
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
项目资助者National Natural Science Foundation of China(21522307 ; Talent Fund of the Recruitment Program of Global Youth Experts ; CAS visiting professorships for senior international scientists(2015VTA033) ; Chinese Academy of Sciences (CAS) ; German Max-Planck Society ; 21473208 ; 91434103 ; 51403214)
WOS记录号WOS:000370656200008
引用统计
被引频次:174[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/20625
专题研究所(批量导入)
通讯作者Yan, Xuehai
作者单位1.Chinese Acad Sci, Natl Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Max Planck Inst Colloids & Interfaces, Muhlenberg 1, D-14476 Potsdam, Germany
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GB/T 7714
Liu, Kai,Xing, Ruirui,Zou, Qianli,et al. Simple Peptide-Tuned Self-Assembly of Photosensitizers towards Anticancer Photodynamic Therapy[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2016,55(9):3036-3039.
APA Liu, Kai,Xing, Ruirui,Zou, Qianli,Ma, Guanghui,Mohwald, Helmuth,&Yan, Xuehai.(2016).Simple Peptide-Tuned Self-Assembly of Photosensitizers towards Anticancer Photodynamic Therapy.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,55(9),3036-3039.
MLA Liu, Kai,et al."Simple Peptide-Tuned Self-Assembly of Photosensitizers towards Anticancer Photodynamic Therapy".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 55.9(2016):3036-3039.
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