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Process for Glycine Production by Antisolvent Crystallization Using Its Phase Equilibria in the Ethylene Glycol-NH4Cl-Water System
Zeng, Yan1,2; Li, Zhibao1; Demopoulos, George P.2
2016-03-02
Source PublicationINDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
ISSN0888-5885
Volume55Issue:8Pages:2426-2437
Abstract

A new process for the production of glycine by using antisolvent crystallization with the mixture of ethylene glycol (MEG) and water as a substitute for methanol has been developed on the basis of chemical modeling phase equilibria for the glycineNH(4)ClMEGH(2)O system. MEG is considered as a green solvent because it has great higher boiling point up to 470 K and thus is almost nonvolatile compared with methanol. We discovered that the solubility of glycine, NH4Cl and their mixtures can be greatly changed by altering the composition of the mixed MEG-H2O solvents and realized the complete separation of glycine and NH4Cl by water evaporation. Phase equilibria for the glycine NH4Cl-MEG-H2O system were measured from 278 to 353 K. The mixed-solvent electrolyte (MSE) model was applied with new binary interaction parameters obtained from regressing experimental and literature data. This newly modified model accurately predicted the solubilities in the quaternary glycine NH4Cl-MEG-H2O system with average absolute relative deviations of 5.84% and 1.03% for glycine and NH4Cl, respectively. Simulation for the new process was performed by the model to investigate its operating conditions, from which the optimal composition of antisolvent was determined to be 50 wt % of MEG solution. Under this condition, glycine and NH4Cl were successfully separated from their solid mixtures in batch crystallization experiments, validating the feasibility of the proposed process for glycine production.

KeywordAqueous Salt Systems Anhydrous Sodium-carbonate Partial Molal Properties Liquid-solid Equilibria Extended Uniquac Model Excess Gibbs Energy Amino-acids Transport-properties Electrolyte Systems High-pressures
SubtypeArticle
Subject AreaEngineering, Chemical ; Engineering
WOS HeadingsScience & Technology ; Technology
DOI10.1021/acs.iecr.5b04144
URL查看原文
Indexed BySCI
Language英语
WOS KeywordAqueous Salt Systems ; Anhydrous Sodium-carbonate ; Partial Molal Properties ; Liquid-solid Equilibria ; Extended Uniquac Model ; Excess Gibbs Energy ; Amino-acids ; Transport-properties ; Electrolyte Systems ; High-pressures
WOS Research AreaEngineering
WOS SubjectEngineering, Chemical
Funding OrganizationNational Natural Science Foundation of China(21476235 ; National Basic Research Development Program of China (973 Program)(2013CB632605) ; U1407112)
WOS IDWOS:000371453800016
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/20688
Collection研究所(批量导入)
Corresponding AuthorLi, Zhibao
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, Beijing 100190, Peoples R China
2.McGill Univ, Dept Min & Mat Engn, 3610 Univ St, Montreal, PQ H3A 2B2, Canada
Recommended Citation
GB/T 7714
Zeng, Yan,Li, Zhibao,Demopoulos, George P.. Process for Glycine Production by Antisolvent Crystallization Using Its Phase Equilibria in the Ethylene Glycol-NH4Cl-Water System[J]. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,2016,55(8):2426-2437.
APA Zeng, Yan,Li, Zhibao,&Demopoulos, George P..(2016).Process for Glycine Production by Antisolvent Crystallization Using Its Phase Equilibria in the Ethylene Glycol-NH4Cl-Water System.INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,55(8),2426-2437.
MLA Zeng, Yan,et al."Process for Glycine Production by Antisolvent Crystallization Using Its Phase Equilibria in the Ethylene Glycol-NH4Cl-Water System".INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH 55.8(2016):2426-2437.
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