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Process for Glycine Production by Antisolvent Crystallization Using Its Phase Equilibria in the Ethylene Glycol-NH4Cl-Water System
Zeng, Yan1,2; Li, Zhibao1; Demopoulos, George P.2
2016-03-02
发表期刊INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
ISSN0888-5885
卷号55期号:8页码:2426-2437
摘要

A new process for the production of glycine by using antisolvent crystallization with the mixture of ethylene glycol (MEG) and water as a substitute for methanol has been developed on the basis of chemical modeling phase equilibria for the glycineNH(4)ClMEGH(2)O system. MEG is considered as a green solvent because it has great higher boiling point up to 470 K and thus is almost nonvolatile compared with methanol. We discovered that the solubility of glycine, NH4Cl and their mixtures can be greatly changed by altering the composition of the mixed MEG-H2O solvents and realized the complete separation of glycine and NH4Cl by water evaporation. Phase equilibria for the glycine NH4Cl-MEG-H2O system were measured from 278 to 353 K. The mixed-solvent electrolyte (MSE) model was applied with new binary interaction parameters obtained from regressing experimental and literature data. This newly modified model accurately predicted the solubilities in the quaternary glycine NH4Cl-MEG-H2O system with average absolute relative deviations of 5.84% and 1.03% for glycine and NH4Cl, respectively. Simulation for the new process was performed by the model to investigate its operating conditions, from which the optimal composition of antisolvent was determined to be 50 wt % of MEG solution. Under this condition, glycine and NH4Cl were successfully separated from their solid mixtures in batch crystallization experiments, validating the feasibility of the proposed process for glycine production.

关键词Aqueous Salt Systems Anhydrous Sodium-carbonate Partial Molal Properties Liquid-solid Equilibria Extended Uniquac Model Excess Gibbs Energy Amino-acids Transport-properties Electrolyte Systems High-pressures
文章类型Article
学科领域Engineering, Chemical ; Engineering
WOS标题词Science & Technology ; Technology
DOI10.1021/acs.iecr.5b04144
URL查看原文
收录类别SCI
语种英语
关键词[WOS]Aqueous Salt Systems ; Anhydrous Sodium-carbonate ; Partial Molal Properties ; Liquid-solid Equilibria ; Extended Uniquac Model ; Excess Gibbs Energy ; Amino-acids ; Transport-properties ; Electrolyte Systems ; High-pressures
WOS研究方向Engineering
WOS类目Engineering, Chemical
项目资助者National Natural Science Foundation of China(21476235 ; National Basic Research Development Program of China (973 Program)(2013CB632605) ; U1407112)
WOS记录号WOS:000371453800016
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/20688
专题研究所(批量导入)
通讯作者Li, Zhibao
作者单位1.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, Beijing 100190, Peoples R China
2.McGill Univ, Dept Min & Mat Engn, 3610 Univ St, Montreal, PQ H3A 2B2, Canada
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GB/T 7714
Zeng, Yan,Li, Zhibao,Demopoulos, George P.. Process for Glycine Production by Antisolvent Crystallization Using Its Phase Equilibria in the Ethylene Glycol-NH4Cl-Water System[J]. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,2016,55(8):2426-2437.
APA Zeng, Yan,Li, Zhibao,&Demopoulos, George P..(2016).Process for Glycine Production by Antisolvent Crystallization Using Its Phase Equilibria in the Ethylene Glycol-NH4Cl-Water System.INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH,55(8),2426-2437.
MLA Zeng, Yan,et al."Process for Glycine Production by Antisolvent Crystallization Using Its Phase Equilibria in the Ethylene Glycol-NH4Cl-Water System".INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH 55.8(2016):2426-2437.
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