CAS OpenIR  > 研究所(批量导入)
Synthesis of a highly fluorescence nitrogen-doped carbon quantum dots bioimaging probe and its in vivo clearance and printing applications
Parvin, Nargish1,3; Mandal, Tapas K.2,3
2016
Source PublicationRSC ADVANCES
ISSN2046-2069
Volume6Issue:22Pages:18134-18140
Abstract

Highly fluorescent, broad range pH and ionic-stable N-doped carbon quantum dots (N-CQDs) were successfully synthesized and their chemical structure and fluorescence mechanism were characterized. Mono-dispersed N-CQDs averaging 4.5 nm in diameter were achieved in a quantum yield (QY) of 74.16%. These N-CQDs showed great potential in biomedical and optical imaging applications both in vivo and in vitro. Biodistribution, retention, toxicity, and pharmacokinetics profiles are mandatory in their potential clinical applications. Herein, the biodistribution, clearance, and toxicity of our invariable N-CQDs species were systematically investigated over 7 days in mice. Most of the N-CQDs were cleared at 6 days post-injection without any accumulation in any vital organs or tissues. Moreover, the high fluorescence N-CQDs were demonstrated to be effective as printing inks for multicolour patterns. This study suggests that N-CQDs may be an attractive alternative to metal quantum dots for secure biomedical and other industrial applications.

KeywordCoated Gold Nanoparticles Sensitive Detection Facile Synthesis Renal Clearance Graphene Oxide Nanodots Toxicity Ions Size Biodistribution
SubtypeArticle
Subject AreaChemistry, Multidisciplinary ; Chemistry
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1039/c5ra25402g
URL查看原文
Indexed BySCI
Language英语
WOS KeywordCoated Gold Nanoparticles ; Sensitive Detection ; Facile Synthesis ; Renal Clearance ; Graphene Oxide ; Nanodots ; Toxicity ; Ions ; Size ; Biodistribution
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
Funding OrganizationSERB ; DST(SR/FT/LS-76/2012) ; DBT Government of India ; Chinese Academy of Science postdoctoral and visiting scholar for developing country programme
WOS IDWOS:000370717900040
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/20708
Collection研究所(批量导入)
Corresponding AuthorMandal, Tapas K.
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Key Lab Biochem Engn, 1 Bei Erjie, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Chem, Bei Yi Jie 2, Beijing 100190, Peoples R China
3.Indian Inst Technol, Dept Biotechnol, Roorkee 247667, Uttar Pradesh, India
Recommended Citation
GB/T 7714
Parvin, Nargish,Mandal, Tapas K.. Synthesis of a highly fluorescence nitrogen-doped carbon quantum dots bioimaging probe and its in vivo clearance and printing applications[J]. RSC ADVANCES,2016,6(22):18134-18140.
APA Parvin, Nargish,&Mandal, Tapas K..(2016).Synthesis of a highly fluorescence nitrogen-doped carbon quantum dots bioimaging probe and its in vivo clearance and printing applications.RSC ADVANCES,6(22),18134-18140.
MLA Parvin, Nargish,et al."Synthesis of a highly fluorescence nitrogen-doped carbon quantum dots bioimaging probe and its in vivo clearance and printing applications".RSC ADVANCES 6.22(2016):18134-18140.
Files in This Item:
File Name/Size DocType Version Access License
Synthesis of a highl(826KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Parvin, Nargish]'s Articles
[Mandal, Tapas K.]'s Articles
Baidu academic
Similar articles in Baidu academic
[Parvin, Nargish]'s Articles
[Mandal, Tapas K.]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Parvin, Nargish]'s Articles
[Mandal, Tapas K.]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.