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Improved Stability of Emulsions in Preparation of Uniform Small-Sized Konjac Glucomanna (KGM) Microspheres with Epoxy-Based Polymer Membrane by Premix Membrane Emulsification
Mi, Yace1,2; Li, Juan1; Zhou, Weiqing1; Zhang, Rongyue1; Ma, Guanghui1; Su, Zhiguo1
2016-03-01
发表期刊POLYMERS
ISSN2073-4360
卷号8期号:3页码:1
摘要Uniform small-sized (<10 mu m) Konjac glucomanna (KGM) microspheres have great application prospects in bio-separation, drug delivery and controlled release. Premix membrane emulsification is an effective method to prepare uniform small-sized KGM microspheres. However, since KGM solution bears strong alkalinity, it requires the membrane to have a hydrophobic surface resistant to alkali. In this study, uniform small-sized KGM microspheres were prepared with epoxy-based polymer membrane (EP) we developed by premix membrane emulsification. It was found that emulsion coalescence and flocculation occurred frequently due to the high interface energy and sedimentation velocity of KGM emulsions. Emulsion stability had a significant influence on the uniformity and dispersity of the final KGM microspheres. To improve the stability of the emulsions, the effects of the concentration of the emulsifier, the viscosity of the KGM solution, the oil phase composition and the feeding method of epoxy chloropropane (EC) on the preparation results were studied. Under optimal preparation conditions (emulsifier 5 wt % PO-5s, KGM III (145.6 mPa center dot s), weight ratio of liquid paraffin (LP) to petroleum ether (PE) 11:1), uniform and stable KGM emulsions (d = 7.47 mu m, CV = 15.35%) were obtained and crosslinked without emulsion-instable phenomena.
关键词Uniform Small-sized Kgm Microspheres Epoxy-based Polymer Membrane (Ep) Alkaline Condition Premix Membrane Emulsification
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
DOI10.3390/polym8030053
收录类别SCI
语种英语
关键词[WOS]ACID
WOS研究方向Polymer Science
WOS类目Polymer Science
项目资助者National Natural Science Foundation of China(21336010) ; Beijing Natural Science Foundation(2162013) ; National Key Technology R&D Program of the Ministry of Science and Technology(2013 BAB01B03) ; National High Technology Research and Development Program of China (863 Program)(2014AA021006)
WOS记录号WOS:000373711700010
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/20997
专题生化工程国家重点实验室
作者单位1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Mi, Yace,Li, Juan,Zhou, Weiqing,et al. Improved Stability of Emulsions in Preparation of Uniform Small-Sized Konjac Glucomanna (KGM) Microspheres with Epoxy-Based Polymer Membrane by Premix Membrane Emulsification[J]. POLYMERS,2016,8(3):1.
APA Mi, Yace,Li, Juan,Zhou, Weiqing,Zhang, Rongyue,Ma, Guanghui,&Su, Zhiguo.(2016).Improved Stability of Emulsions in Preparation of Uniform Small-Sized Konjac Glucomanna (KGM) Microspheres with Epoxy-Based Polymer Membrane by Premix Membrane Emulsification.POLYMERS,8(3),1.
MLA Mi, Yace,et al."Improved Stability of Emulsions in Preparation of Uniform Small-Sized Konjac Glucomanna (KGM) Microspheres with Epoxy-Based Polymer Membrane by Premix Membrane Emulsification".POLYMERS 8.3(2016):1.
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