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Improved Stability of Emulsions in Preparation of Uniform Small-Sized Konjac Glucomanna (KGM) Microspheres with Epoxy-Based Polymer Membrane by Premix Membrane Emulsification
Mi, Yace1,2; Li, Juan1; Zhou, Weiqing1; Zhang, Rongyue1; Ma, Guanghui1; Su, Zhiguo1
2016-03-01
Source PublicationPOLYMERS
ISSN2073-4360
Volume8Issue:3Pages:1
AbstractUniform small-sized (<10 mu m) Konjac glucomanna (KGM) microspheres have great application prospects in bio-separation, drug delivery and controlled release. Premix membrane emulsification is an effective method to prepare uniform small-sized KGM microspheres. However, since KGM solution bears strong alkalinity, it requires the membrane to have a hydrophobic surface resistant to alkali. In this study, uniform small-sized KGM microspheres were prepared with epoxy-based polymer membrane (EP) we developed by premix membrane emulsification. It was found that emulsion coalescence and flocculation occurred frequently due to the high interface energy and sedimentation velocity of KGM emulsions. Emulsion stability had a significant influence on the uniformity and dispersity of the final KGM microspheres. To improve the stability of the emulsions, the effects of the concentration of the emulsifier, the viscosity of the KGM solution, the oil phase composition and the feeding method of epoxy chloropropane (EC) on the preparation results were studied. Under optimal preparation conditions (emulsifier 5 wt % PO-5s, KGM III (145.6 mPa center dot s), weight ratio of liquid paraffin (LP) to petroleum ether (PE) 11:1), uniform and stable KGM emulsions (d = 7.47 mu m, CV = 15.35%) were obtained and crosslinked without emulsion-instable phenomena.
KeywordUniform Small-sized Kgm Microspheres Epoxy-based Polymer Membrane (Ep) Alkaline Condition Premix Membrane Emulsification
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.3390/polym8030053
Indexed BySCI
Language英语
WOS KeywordACID
WOS Research AreaPolymer Science
WOS SubjectPolymer Science
Funding OrganizationNational Natural Science Foundation of China(21336010) ; Beijing Natural Science Foundation(2162013) ; National Key Technology R&D Program of the Ministry of Science and Technology(2013 BAB01B03) ; National High Technology Research and Development Program of China (863 Program)(2014AA021006)
WOS IDWOS:000373711700010
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/20997
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Mi, Yace,Li, Juan,Zhou, Weiqing,et al. Improved Stability of Emulsions in Preparation of Uniform Small-Sized Konjac Glucomanna (KGM) Microspheres with Epoxy-Based Polymer Membrane by Premix Membrane Emulsification[J]. POLYMERS,2016,8(3):1.
APA Mi, Yace,Li, Juan,Zhou, Weiqing,Zhang, Rongyue,Ma, Guanghui,&Su, Zhiguo.(2016).Improved Stability of Emulsions in Preparation of Uniform Small-Sized Konjac Glucomanna (KGM) Microspheres with Epoxy-Based Polymer Membrane by Premix Membrane Emulsification.POLYMERS,8(3),1.
MLA Mi, Yace,et al."Improved Stability of Emulsions in Preparation of Uniform Small-Sized Konjac Glucomanna (KGM) Microspheres with Epoxy-Based Polymer Membrane by Premix Membrane Emulsification".POLYMERS 8.3(2016):1.
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