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Positively charged armed nanoparticles demonstrate their precise delivery performance for effective treatment of chorioretinal diseases
Wei, Wei1; Zhu, Dan2; Wang, Zhenhua2; Ni, Dezhi1; Yue, Hua1; Wang, Shuang1; Tao, Yong3,4,5; Ma, Guanghui1
2016
发表期刊JOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
卷号4期号:15页码:2548-2552
摘要Recruiting positively charged armed nanoparticles into the ocular fundus was achieved by utilizing the natural intraocular electrical field. Their subsequent penetration into the fundus sub-layers was also tuned by optimizing the surface charge density. In addition to the sustained release behavior, such a precise delivery fulfilled various intraocular delivery requirements for different chorioretinal diseases.
文章类型Article
WOS标题词Science & Technology ; Technology
DOI10.1039/c5tb02568k
收录类别SCI
语种英语
关键词[WOS]CHITOSAN-BASED NANOPARTICLES ; DRUG-DELIVERY ; SUPPRESSION ; PACLITAXEL ; INJECTION
WOS研究方向Materials Science
WOS类目Materials Science, Biomaterials
项目资助者National High Technology Research and Development Program of China(2015AA020949) ; Beijing Nova Program(Z1511000003150148) ; Program for New Century Excellent Talents in University(NCET-12-0010) ; Fok Ying-Tong Education Foundation(141038)
WOS记录号WOS:000374098800003
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文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/21000
专题生化工程国家重点实验室
作者单位1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Inner Mongolia Med Univ, Affiliated Hosp, Hohhot 010050, Inner Mongolia, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100044, Peoples R China
4.Minist Educ, Key Lab Vis Loss & Restorat, Beijing 100044, Peoples R China
5.Capital Med Univ, Beijing Chaoyang Hosp, Dept Ophthalmol, Beijing 100020, Peoples R China
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Wei, Wei,Zhu, Dan,Wang, Zhenhua,et al. Positively charged armed nanoparticles demonstrate their precise delivery performance for effective treatment of chorioretinal diseases[J]. JOURNAL OF MATERIALS CHEMISTRY B,2016,4(15):2548-2552.
APA Wei, Wei.,Zhu, Dan.,Wang, Zhenhua.,Ni, Dezhi.,Yue, Hua.,...&Ma, Guanghui.(2016).Positively charged armed nanoparticles demonstrate their precise delivery performance for effective treatment of chorioretinal diseases.JOURNAL OF MATERIALS CHEMISTRY B,4(15),2548-2552.
MLA Wei, Wei,et al."Positively charged armed nanoparticles demonstrate their precise delivery performance for effective treatment of chorioretinal diseases".JOURNAL OF MATERIALS CHEMISTRY B 4.15(2016):2548-2552.
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