| Nano-Delivery Vehicles/Adjuvants for DNA Vaccination Against HIV | |
| Dong, Yaqiong1,2; Yang, Jun1; Zhang, Jinchao2; Zhang, Xin1 | |
| 2016-03-01 | |
| 发表期刊 | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
 |
| ISSN | 1533-4880 |
| 卷号 | 16期号:3页码:2126-2133 |
| 摘要 | More than 75 million people has been infected HIV and it is responsible for nearly 36 million deaths on a global scale. As one of the deadliest infectious diseases, HIV is becoming the urgent issue of the global epidemic to tackle. In order to settle this problem from the source, some effective prevention strategies should be developed to control the pandemic of HIV. Vaccines, especially DNA vaccines, could be the optimal way to control the spread of HIV due to the unparalleled superiority that DNA vaccines could generate long-term humoral and cellular immune responses which could provide protective immunity for HIV. But the naked DNA could hardly enter into cells and is easily degraded by DNases and lysosomes, so designing effective delivery system is a promising strategy. Since delivery system could be constructed to promote efficient delivery of DNA into mammalian cells, protect them from degradation, and also could be established to be a target system to arrive at certain position of expectation. The current review discusses the potential of various nano-delivery vehicles/adjuvants such as polymer, lipid, liposome, peptide and inorganic material in improving efficiency of diverse modalities available for HIV DNA vaccines. |
| 关键词 | Hiv Dna Vaccine Immunogenicity Nano-delivery Vehicles Adjuvants |
| 文章类型 | Review |
| WOS标题词 | Science & Technology ; Physical Sciences ; Technology |
| DOI | 10.1166/jnn.2016.10947 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | IMMUNODEFICIENCY-VIRUS TYPE-1 ; MEDIATED IMMUNE-RESPONSES ; MONOPHOSPHORYL-LIPID-A ; HEPATITIS-B-VACCINE ; GENE DELIVERY ; CHITOSAN NANOPARTICLES ; CONTROLLED-RELEASE ; PEI/DNA COMPLEXES ; DRUG-DELIVERY ; PEPTIDE |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 项目资助者 | National Natural Science Foundation of China(21271059 ; National High Technology Research and Development Program(2012AA022703 ; Instrument Developing Project of the Chinese Academy of Sciences(YZ201253 ; Open Funding Project of the National Key Laboratory of Biochemical Engineering(Y22504A169) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA09030301-3) ; "Three Three Three" Talents Project of Hebei Province(A201401002) ; Hebei Province "Hundred Talents Program"(BR2-202) ; 21304099 ; 2012AA020804 ; YZ201313) ; 51203162 ; 2014AA020708) ; 51103159 ; 51373177) |
| WOS记录号 | WOS:000374153800003 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ipe.ac.cn/handle/122111/21010 |
| 专题 | 生化工程国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Natl Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China 2.Hebei Univ, Coll Chem & Environm Sci, Chem Biol Key Lab Hebei Prov, Key Lab Med Chem & Mol Diag,Minist Educ, Baoding 071002, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Yaqiong,Yang, Jun,Zhang, Jinchao,et al. Nano-Delivery Vehicles/Adjuvants for DNA Vaccination Against HIV[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2016,16(3):2126-2133. |
| APA | Dong, Yaqiong,Yang, Jun,Zhang, Jinchao,&Zhang, Xin.(2016).Nano-Delivery Vehicles/Adjuvants for DNA Vaccination Against HIV.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,16(3),2126-2133. |
| MLA | Dong, Yaqiong,et al."Nano-Delivery Vehicles/Adjuvants for DNA Vaccination Against HIV".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 16.3(2016):2126-2133. |
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