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Nano-Delivery Vehicles/Adjuvants for DNA Vaccination Against HIV
Dong, Yaqiong1,2; Yang, Jun1; Zhang, Jinchao2; Zhang, Xin1
2016-03-01
发表期刊JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
ISSN1533-4880
卷号16期号:3页码:2126-2133
摘要More than 75 million people has been infected HIV and it is responsible for nearly 36 million deaths on a global scale. As one of the deadliest infectious diseases, HIV is becoming the urgent issue of the global epidemic to tackle. In order to settle this problem from the source, some effective prevention strategies should be developed to control the pandemic of HIV. Vaccines, especially DNA vaccines, could be the optimal way to control the spread of HIV due to the unparalleled superiority that DNA vaccines could generate long-term humoral and cellular immune responses which could provide protective immunity for HIV. But the naked DNA could hardly enter into cells and is easily degraded by DNases and lysosomes, so designing effective delivery system is a promising strategy. Since delivery system could be constructed to promote efficient delivery of DNA into mammalian cells, protect them from degradation, and also could be established to be a target system to arrive at certain position of expectation. The current review discusses the potential of various nano-delivery vehicles/adjuvants such as polymer, lipid, liposome, peptide and inorganic material in improving efficiency of diverse modalities available for HIV DNA vaccines.
关键词Hiv Dna Vaccine Immunogenicity Nano-delivery Vehicles Adjuvants
文章类型Review
WOS标题词Science & Technology ; Physical Sciences ; Technology
DOI10.1166/jnn.2016.10947
收录类别SCI
语种英语
关键词[WOS]IMMUNODEFICIENCY-VIRUS TYPE-1 ; MEDIATED IMMUNE-RESPONSES ; MONOPHOSPHORYL-LIPID-A ; HEPATITIS-B-VACCINE ; GENE DELIVERY ; CHITOSAN NANOPARTICLES ; CONTROLLED-RELEASE ; PEI/DNA COMPLEXES ; DRUG-DELIVERY ; PEPTIDE
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS类目Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
项目资助者National Natural Science Foundation of China(21271059 ; National High Technology Research and Development Program(2012AA022703 ; Instrument Developing Project of the Chinese Academy of Sciences(YZ201253 ; Open Funding Project of the National Key Laboratory of Biochemical Engineering(Y22504A169) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDA09030301-3) ; "Three Three Three" Talents Project of Hebei Province(A201401002) ; Hebei Province "Hundred Talents Program"(BR2-202) ; 21304099 ; 2012AA020804 ; YZ201313) ; 51203162 ; 2014AA020708) ; 51103159 ; 51373177)
WOS记录号WOS:000374153800003
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/21010
专题生化工程国家重点实验室
作者单位1.Chinese Acad Sci, Natl Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
2.Hebei Univ, Coll Chem & Environm Sci, Chem Biol Key Lab Hebei Prov, Key Lab Med Chem & Mol Diag,Minist Educ, Baoding 071002, Peoples R China
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GB/T 7714
Dong, Yaqiong,Yang, Jun,Zhang, Jinchao,et al. Nano-Delivery Vehicles/Adjuvants for DNA Vaccination Against HIV[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2016,16(3):2126-2133.
APA Dong, Yaqiong,Yang, Jun,Zhang, Jinchao,&Zhang, Xin.(2016).Nano-Delivery Vehicles/Adjuvants for DNA Vaccination Against HIV.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,16(3),2126-2133.
MLA Dong, Yaqiong,et al."Nano-Delivery Vehicles/Adjuvants for DNA Vaccination Against HIV".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 16.3(2016):2126-2133.
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