Mesoporous silica nanoparticles with organo-bridged silsesquioxane framework as innovative platforms for bioimaging and therapeutic agent delivery
Du, Xin1,5; Li, Xiaoyu2; Xiong, Lin5; Zhang, Xueji1; Kleitz, Freddy3,4; Qiao, Shi Zhang5
2016-06-01
发表期刊BIOMATERIALS
ISSN0142-9612
卷号91期号:JUNE页码:90-127
摘要Mesoporous silica material with organo-bridged silsesquioxane frameworks is a kind of synergistic combination of inorganic silica, mesopores and organics, resulting in some novel or enhanced physicochemical and biocompatible properties compared with conventional mesoporous silica materials with pure Si-O composition. With the rapid development of nanotechnology, monodispersed nanoscale periodic mesoporous organosilica nanoparticles (PMO NPs) and organo-bridged mesoporous silica nano particles (MSNs) with various organic groups and structures have recently been synthesized from 100%, or less, bridged organosilica precursors, respectively. Since then, these materials have been employed as carrier platforms to construct bioimaging and/or therapeutic agent delivery nanosystems for nano biomedical application, and they demonstrate some unique and/or enhanced properties and performances. This review article provides a comprehensive overview of the controlled synthesis of PMO NPs and organ-bridged MSNs, physicochemical and biocompatible properties, and their nano-biomedical application as bioimaging agent and/or therapeutic agent delivery system. (c) 2016 Elsevier Ltd. All rights reserved.
关键词Pmos Mesoporous Nanoparticles Biocompatible Properties Advanced Nanocarriers Bioimaging Therapeutic Agent Delivery
文章类型Review
WOS标题词Science & Technology ; Technology
DOI10.1016/j.biomaterials.2016.03.019
收录类别SCI
语种英语
关键词[WOS]INORGANIC HYBRID MATERIALS ; DRUG-DELIVERY ; GENE DELIVERY ; HOLLOW SPHERES ; CANCER-CELLS ; BIOMEDICAL APPLICATIONS ; FLUORESCENT HYBRID ; PORE WALLS ; TOPOLOGICAL TRANSFORMATION ; SURFACE FUNCTIONALIZATION
WOS研究方向Engineering ; Materials Science
WOS类目Engineering, Biomedical ; Materials Science, Biomaterials
项目资助者National Natural Science Foundation of China(21501009 ; High-Level Talent Introduction Plan of University of Science & Technology Beijing(06500017) ; Fundamental Research Funds for the Central Universities(FRF-TP-15-019A1) ; Australian Research Council (ARC)(DP130104459 ; Natural Sciences and Engineering Research Council of Canada (NSERC) ; 21127007) ; DP140104062)
WOS记录号WOS:000374611900008
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被引频次:66[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/21015
专题湿法冶金清洁生产技术国家工程实验室
作者单位1.Univ Sci & Technol Beijing, Res Ctr Bioengn & Sensing Technol, Beijing 100083, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, Beijing 100190, Peoples R China
3.Univ Laval, Dept Chem, Quebec City, PQ G1V 0A6, Canada
4.Univ Laval, Ctr Rech Mat Avances CERMA, Quebec City, PQ G1V 0A6, Canada
5.Univ Adelaide, Sch Chem Engn, Adelaide, SA 5005, Australia
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Du, Xin,Li, Xiaoyu,Xiong, Lin,et al. Mesoporous silica nanoparticles with organo-bridged silsesquioxane framework as innovative platforms for bioimaging and therapeutic agent delivery[J]. BIOMATERIALS,2016,91(JUNE):90-127.
APA Du, Xin,Li, Xiaoyu,Xiong, Lin,Zhang, Xueji,Kleitz, Freddy,&Qiao, Shi Zhang.(2016).Mesoporous silica nanoparticles with organo-bridged silsesquioxane framework as innovative platforms for bioimaging and therapeutic agent delivery.BIOMATERIALS,91(JUNE),90-127.
MLA Du, Xin,et al."Mesoporous silica nanoparticles with organo-bridged silsesquioxane framework as innovative platforms for bioimaging and therapeutic agent delivery".BIOMATERIALS 91.JUNE(2016):90-127.
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