| Mesoporous silica nanoparticles with organo-bridged silsesquioxane framework as innovative platforms for bioimaging and therapeutic agent delivery | |
| Du, Xin1,5; Li, Xiaoyu2; Xiong, Lin5; Zhang, Xueji1; Kleitz, Freddy3,4; Qiao, Shi Zhang5 | |
| 2016-06-01 | |
| Source Publication | BIOMATERIALS
 |
| ISSN | 0142-9612 |
| Volume | 91Issue:JUNEPages:90-127 |
| Abstract | Mesoporous silica material with organo-bridged silsesquioxane frameworks is a kind of synergistic combination of inorganic silica, mesopores and organics, resulting in some novel or enhanced physicochemical and biocompatible properties compared with conventional mesoporous silica materials with pure Si-O composition. With the rapid development of nanotechnology, monodispersed nanoscale periodic mesoporous organosilica nanoparticles (PMO NPs) and organo-bridged mesoporous silica nano particles (MSNs) with various organic groups and structures have recently been synthesized from 100%, or less, bridged organosilica precursors, respectively. Since then, these materials have been employed as carrier platforms to construct bioimaging and/or therapeutic agent delivery nanosystems for nano biomedical application, and they demonstrate some unique and/or enhanced properties and performances. This review article provides a comprehensive overview of the controlled synthesis of PMO NPs and organ-bridged MSNs, physicochemical and biocompatible properties, and their nano-biomedical application as bioimaging agent and/or therapeutic agent delivery system. (c) 2016 Elsevier Ltd. All rights reserved. |
| Keyword | Pmos Mesoporous Nanoparticles Biocompatible Properties Advanced Nanocarriers Bioimaging Therapeutic Agent Delivery |
| Subtype | Review |
| WOS Headings | Science & Technology ; Technology |
| DOI | 10.1016/j.biomaterials.2016.03.019 |
| Indexed By | SCI |
| Language | 英语 |
| WOS Keyword | INORGANIC HYBRID MATERIALS ; DRUG-DELIVERY ; GENE DELIVERY ; HOLLOW SPHERES ; CANCER-CELLS ; BIOMEDICAL APPLICATIONS ; FLUORESCENT HYBRID ; PORE WALLS ; TOPOLOGICAL TRANSFORMATION ; SURFACE FUNCTIONALIZATION |
| WOS Research Area | Engineering ; Materials Science |
| WOS Subject | Engineering, Biomedical ; Materials Science, Biomaterials |
| Funding Organization | National Natural Science Foundation of China(21501009 ; High-Level Talent Introduction Plan of University of Science & Technology Beijing(06500017) ; Fundamental Research Funds for the Central Universities(FRF-TP-15-019A1) ; Australian Research Council (ARC)(DP130104459 ; Natural Sciences and Engineering Research Council of Canada (NSERC) ; 21127007) ; DP140104062) |
| WOS ID | WOS:000374611900008 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/21015 |
| Collection | 湿法冶金清洁生产技术国家工程实验室 |
| Affiliation | 1.Univ Sci & Technol Beijing, Res Ctr Bioengn & Sensing Technol, Beijing 100083, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, Beijing 100190, Peoples R China 3.Univ Laval, Dept Chem, Quebec City, PQ G1V 0A6, Canada 4.Univ Laval, Ctr Rech Mat Avances CERMA, Quebec City, PQ G1V 0A6, Canada 5.Univ Adelaide, Sch Chem Engn, Adelaide, SA 5005, Australia |
| Recommended Citation GB/T 7714 | Du, Xin,Li, Xiaoyu,Xiong, Lin,et al. Mesoporous silica nanoparticles with organo-bridged silsesquioxane framework as innovative platforms for bioimaging and therapeutic agent delivery[J]. BIOMATERIALS,2016,91(JUNE):90-127. |
| APA | Du, Xin,Li, Xiaoyu,Xiong, Lin,Zhang, Xueji,Kleitz, Freddy,&Qiao, Shi Zhang.(2016).Mesoporous silica nanoparticles with organo-bridged silsesquioxane framework as innovative platforms for bioimaging and therapeutic agent delivery.BIOMATERIALS,91(JUNE),90-127. |
| MLA | Du, Xin,et al."Mesoporous silica nanoparticles with organo-bridged silsesquioxane framework as innovative platforms for bioimaging and therapeutic agent delivery".BIOMATERIALS 91.JUNE(2016):90-127. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Mesoporous silica na（16077KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | Application Full Text | |
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