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Revealing the role of oxidation state in interaction between nitro/amino-derived particulate matter and blood proteins
Liu, Zhen1; Li, Ping2,3; Bian, Weiwei4; Yu, Jingkai2; Zhan, Jinhua1
2016-05-16
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume6Issue:MAYPages:25909
AbstractSurface oxidation states of ultrafine particulate matter can influence the proinflammatory responses and reactive oxygen species levels in tissue. Surface active species of vehicle-emission soot can serve as electron transfer-mediators in mitochondrion. Revealing the role of surface oxidation state in particles-proteins interaction will promote the understanding on metabolism and toxicity. Here, the surface oxidation state was modeled by nitro/amino ligands on nanoparticles, the interaction with blood proteins were evaluated by capillary electrophoresis quantitatively. The nitro shown larger affinity than amino. On the other hand, the affinity to hemoglobin is 103 times larger than that to BSA. Further, molecular docking indicated the difference of binding intensity were mainly determined by hydrophobic forces and hydrogen bonds. These will deepen the quantitative understanding of protein-nanoparticles interaction from the perspective of surface chemical state.
SubtypeArticle
WOS HeadingsScience & Technology
DOI10.1038/srep25909
Indexed BySCI
Language英语
WOS KeywordBOVINE SERUM-ALBUMIN ; ENHANCED RAMAN-SCATTERING ; ESTERASE-LIKE ACTIVITY ; CRYSTALLOGRAPHIC ANALYSIS ; NITROPHENYL ESTERS ; FREE-RADICALS ; NANOPARTICLES ; POLLUTION ; BINDING ; SURFACE
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
Funding OrganizationNational Basic Research Program of China (973 Program)(2013CB934301) ; National Natural Science Foundation of China(NSFC21377068 ; 21575077)
WOS IDWOS:000375919200002
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/21051
Collection生化工程国家重点实验室
Affiliation1.Shandong Univ, Minist Educ, Dept Chem, Key Lab Colloid & Interface Chem, Jinan 250100, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Weifang Med Univ, Dept Pharm, Weifang 261053, Peoples R China
Recommended Citation
GB/T 7714
Liu, Zhen,Li, Ping,Bian, Weiwei,et al. Revealing the role of oxidation state in interaction between nitro/amino-derived particulate matter and blood proteins[J]. SCIENTIFIC REPORTS,2016,6(MAY):25909.
APA Liu, Zhen,Li, Ping,Bian, Weiwei,Yu, Jingkai,&Zhan, Jinhua.(2016).Revealing the role of oxidation state in interaction between nitro/amino-derived particulate matter and blood proteins.SCIENTIFIC REPORTS,6(MAY),25909.
MLA Liu, Zhen,et al."Revealing the role of oxidation state in interaction between nitro/amino-derived particulate matter and blood proteins".SCIENTIFIC REPORTS 6.MAY(2016):25909.
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