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Direct and controllable preparation of uniform PLGA particles with various shapes and surface morphologies
Fan, Qingze1,2; Qi, Feng1,2; Miao, Chunyu1,3; Yue, Hua1,3; Gong, Fangling1,3; Wu, Jie1,3; Ma, Guanghui1,3; Su, Zhiguo1,3
2016-07-05
发表期刊COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
ISSN0927-7757
卷号500期号:AUG页码:177-185
摘要Biodegradable polymeric particles have been widely used in the biomedical fields such as drug carriers, tissue engineering, and medical imaging. It has been recognized that the physical properties of particles, such as size and shape, have a profound influence on their functions. However, it is not easy to prepare non-spherical particles by the conventional emulsion-based method because the minimization of interfacial energy leads to the spontaneous formation of spherical emulsions and it is difficult to control the uniformity and size. In order to solve this problem, we developed a direct method to fabricate non spherical polylactic-co-glycolic acid (PLGA) particles with uniform size. This method employed a common agent, phosphate buffer saline (PBS), as the deformation initiator and combined the premix membrane emulsification technique with the solvent evaporation method to prepare uniform non-spherical particles of various shapes with aspect ratios from 2 to 40 and various sizes ranging from 800 nm to 60 pin (long axis). We found that the external driving force of stirring and the interfacial tension of the droplet dictated by the constitution of PBS and polyvinyl alcohol (PVA) have synergistic effects on the deformation. Through confocal laser microscopy (CLSM), the deforming process was observed visually in the solvent and gel state during the solidification. Moreover, octreotide acetate as a model peptide was successfully encapsulated into the non-spherical particles.
关键词Non-spherical Particles Uniform Size Deformation Premix Membrane Emulsification Technique Drug Delivery System
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
DOI10.1016/j.colsurfa.2016.04.028
收录类别SCI
语种英语
关键词[WOS]DRUG-DELIVERY ; POLYMERIC NANOPARTICLES ; MICROSPHERES ; MICROPARTICLES ; MONODISPERSE ; FABRICATION ; BIODISTRIBUTION ; MICROFLUIDICS ; PHAGOCYTOSIS ; SIZE
WOS研究方向Chemistry
WOS类目Chemistry, Physical
项目资助者National Science and Technology Major Project(2014ZX09102045) ; NSFC(21576268 ; 51403213 ; 21336010)
WOS记录号WOS:000375860100021
引用统计
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/21052
专题生化工程国家重点实验室
作者单位1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, PLA Key Lab Biopharmaceut Prod & Formulat Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Nanjing, Jiangsu, Peoples R China
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Fan, Qingze,Qi, Feng,Miao, Chunyu,et al. Direct and controllable preparation of uniform PLGA particles with various shapes and surface morphologies[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2016,500(AUG):177-185.
APA Fan, Qingze.,Qi, Feng.,Miao, Chunyu.,Yue, Hua.,Gong, Fangling.,...&Su, Zhiguo.(2016).Direct and controllable preparation of uniform PLGA particles with various shapes and surface morphologies.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,500(AUG),177-185.
MLA Fan, Qingze,et al."Direct and controllable preparation of uniform PLGA particles with various shapes and surface morphologies".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 500.AUG(2016):177-185.
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