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Direct and controllable preparation of uniform PLGA particles with various shapes and surface morphologies
Fan, Qingze1,2; Qi, Feng1,2; Miao, Chunyu1,3; Yue, Hua1,3; Gong, Fangling1,3; Wu, Jie1,3; Ma, Guanghui1,3; Su, Zhiguo1,3
2016-07-05
Source PublicationCOLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
ISSN0927-7757
Volume500Issue:AUGPages:177-185
AbstractBiodegradable polymeric particles have been widely used in the biomedical fields such as drug carriers, tissue engineering, and medical imaging. It has been recognized that the physical properties of particles, such as size and shape, have a profound influence on their functions. However, it is not easy to prepare non-spherical particles by the conventional emulsion-based method because the minimization of interfacial energy leads to the spontaneous formation of spherical emulsions and it is difficult to control the uniformity and size. In order to solve this problem, we developed a direct method to fabricate non spherical polylactic-co-glycolic acid (PLGA) particles with uniform size. This method employed a common agent, phosphate buffer saline (PBS), as the deformation initiator and combined the premix membrane emulsification technique with the solvent evaporation method to prepare uniform non-spherical particles of various shapes with aspect ratios from 2 to 40 and various sizes ranging from 800 nm to 60 pin (long axis). We found that the external driving force of stirring and the interfacial tension of the droplet dictated by the constitution of PBS and polyvinyl alcohol (PVA) have synergistic effects on the deformation. Through confocal laser microscopy (CLSM), the deforming process was observed visually in the solvent and gel state during the solidification. Moreover, octreotide acetate as a model peptide was successfully encapsulated into the non-spherical particles.
KeywordNon-spherical Particles Uniform Size Deformation Premix Membrane Emulsification Technique Drug Delivery System
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1016/j.colsurfa.2016.04.028
Indexed BySCI
Language英语
WOS KeywordDRUG-DELIVERY ; POLYMERIC NANOPARTICLES ; MICROSPHERES ; MICROPARTICLES ; MONODISPERSE ; FABRICATION ; BIODISTRIBUTION ; MICROFLUIDICS ; PHAGOCYTOSIS ; SIZE
WOS Research AreaChemistry
WOS SubjectChemistry, Physical
Funding OrganizationNational Science and Technology Major Project(2014ZX09102045) ; NSFC(21576268 ; 51403213 ; 21336010)
WOS IDWOS:000375860100021
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/21052
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, PLA Key Lab Biopharmaceut Prod & Formulat Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Nanjing, Jiangsu, Peoples R China
Recommended Citation
GB/T 7714
Fan, Qingze,Qi, Feng,Miao, Chunyu,et al. Direct and controllable preparation of uniform PLGA particles with various shapes and surface morphologies[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2016,500(AUG):177-185.
APA Fan, Qingze.,Qi, Feng.,Miao, Chunyu.,Yue, Hua.,Gong, Fangling.,...&Su, Zhiguo.(2016).Direct and controllable preparation of uniform PLGA particles with various shapes and surface morphologies.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,500(AUG),177-185.
MLA Fan, Qingze,et al."Direct and controllable preparation of uniform PLGA particles with various shapes and surface morphologies".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 500.AUG(2016):177-185.
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