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Regulating Cell Apoptosis on Layer-by-Layer Assembled Multilayers of Photosensitizer-Coupled Polypeptides and Gold Nanoparticles
Xing, Ruirui1,2,3; Jiao, Tifeng1,2; Ma, Kai2,3; Ma, Guanghui3; Moehwald, Helmuth4; Yan, Xuehai3
2016-05-23
发表期刊SCIENTIFIC REPORTS
ISSN2045-2322
卷号6期号:MAY页码:26506
摘要The design of advanced, nanostructured materials by layer-by-layer (LbL) assembly at the molecular level is of great interest because of the broad application of these materials in the biomedical field especially in regulating cell growth, adhesion, movement, differentiation and detachment. Here, we fabricated functional hybrid multilayer films by LbL assembly of biocompatible photosensitizer-coupled polypeptides and collagen-capped gold nanoparticles. The resulting multilayer film can well accommodate cells for adhesion, growth and proliferation. Most significantly, controlled cell apoptosis (detachment) and patterning of the multilayer film is achieved by a photochemical process yielding reactive oxygen species (ROS). Moreover, the site and shape of apoptotic cells can be controlled easily by adjusting the location and shape of the laser beam. The LbL assembled multilayer film with integration of functions provides an efficient platform for regulating cell growth and apoptosis (detachment).
文章类型Article
WOS标题词Science & Technology
DOI10.1038/srep26506
收录类别SCI
语种英语
关键词[WOS]MECHANICAL-PROPERTIES ; SURFACES ; FILMS ; POLYELECTROLYTE ; DETACHMENT ; ADHESION ; SYSTEMS ; GROWTH ; TRANSFECTION ; NANOTUBES
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
项目资助者National Natural Science Foundation of China(21522307 ; Talent Fund of the Recruitment Program of Global Youth Experts ; Chinese Academy of Sciences (CAS) ; Natural Science Foundation of China(21473153) ; Science Foundation for the Excellent Youth Scholars from Universities and Colleges of Hebei Province(YQ2013026) ; Support Program for the Top Young Talents of Hebei Province ; Post-graduate's Innovation Fund Project of Hebei Province(2016SJBS009) ; China Postdoctoral Science Foundation(2015M580214) ; Scientific and Technological Research and Development Program of Qinhuangdao City(201502A006) ; CAS(2015VTA033) ; 21473208 ; 91434103 ; 51403214)
WOS记录号WOS:000376357000001
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文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/21084
专题生化工程国家重点实验室
作者单位1.Yanshan Univ, State Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Peoples R China
2.Yanshan Univ, Sch Environm & Chem Engn, Hebei Key Lab Appl Chem, Qinhuangdao 066004, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
4.Max Planck Inst Colloids & Interfaces, Muhlenberg 1, D-14476 Potsdam, Germany
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Xing, Ruirui,Jiao, Tifeng,Ma, Kai,et al. Regulating Cell Apoptosis on Layer-by-Layer Assembled Multilayers of Photosensitizer-Coupled Polypeptides and Gold Nanoparticles[J]. SCIENTIFIC REPORTS,2016,6(MAY):26506.
APA Xing, Ruirui,Jiao, Tifeng,Ma, Kai,Ma, Guanghui,Moehwald, Helmuth,&Yan, Xuehai.(2016).Regulating Cell Apoptosis on Layer-by-Layer Assembled Multilayers of Photosensitizer-Coupled Polypeptides and Gold Nanoparticles.SCIENTIFIC REPORTS,6(MAY),26506.
MLA Xing, Ruirui,et al."Regulating Cell Apoptosis on Layer-by-Layer Assembled Multilayers of Photosensitizer-Coupled Polypeptides and Gold Nanoparticles".SCIENTIFIC REPORTS 6.MAY(2016):26506.
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