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Carrier-Free, Chemophotodynamic Dual Nanodrugs via Self-Assembly for Synergistic Antitumor Therapy
Zhang, Ruiyun1,2; Xing, Ruirui1,2,3; Jiao, Tifeng1,2; Ma, Kai1,2; Chen, Chengjun3,4; Ma, Guanghui3; Yan, Xuehai3,4
2016-06-01
发表期刊ACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
卷号8期号:21页码:13262-13269
摘要There are tremendous challenges from both tumor and its therapeutic formulations affecting the effective treatment of tumor, including tumor recurrence, and complex multistep preparations of formulation. To address these issues, herein a simple and green approach based on the self-assembly of therapeutic agents including a photosensitizer (chlorine e6, Ce6) and a chemotherapeutic agent (doxorubicin, DOX) was developed to prepare carrier free nanoparticles (NPs) with the ability to inhibit tumor recurrence. The designed NPs were formed by self-assembly of Ce6 and DOX associated with electrostatic, pi-pi stacking and hydrophobic interactions. They have a relatively uniform size of average 70 nm, surface charge of -20 mV and high drug encapsulation efficiency, which benefits the favorable accumulation of drugs at the tumor region through a potential enhanced permeability and retention (EPR) effect as compared to their counterpart of free Ce6 solution. In addition, they could eradiate tumors without recurrence in a synergistic way following one treatment cycle. Furthermore, the NPs are safe without any activation of inflammation or immune response in separated organs. Taken together, the rationale of these pure nanodrugs via the self-assembly approach might open an alternative avenue and give inspiration to fabricate new carrier-free nanodrugs for tumor theranostics, especially for two small molecular antitumor drugs with the aim of combinational antitumor therapy in a synergistic way.
关键词Nanodrugs Self-assembly Codelivery Photodynamic Therapy Antitumor Therapy
文章类型Article
WOS标题词Science & Technology ; Technology
DOI10.1021/acsami.6b02416
收录类别SCI
语种英语
关键词[WOS]OVERCOMING DRUG-RESISTANCE ; PHOTODYNAMIC THERAPY ; CANCER-THERAPY ; BIOMEDICAL APPLICATIONS ; MULTIDRUG-RESISTANCE ; SIRNA DELIVERY ; IN-VITRO ; NANOPARTICLES ; PROTEIN ; COMBINATION
WOS研究方向Science & Technology - Other Topics ; Materials Science
WOS类目Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
项目资助者National Natural Science Foundation of China(21522307 ; Beijing Natural Science Foundation(7154220) ; Youth Innovation Promotion Association CAS ; CAS visiting professorships for senior international scientists(2016VTA042) ; Chinese Academy of Sciences (CAS) ; Natural Science Foundation of China(21473153) ; Science Foundation for the Excellent Youth Scholars from Universities and Colleges of Hebei Province(YQ2013026) ; Support Program for the Top Young Talents of Hebei Province ; Postgraduate's Innovation Fund Project of Hebei Province(2016SJBS009) ; China Postdoctoral Science Foundation(2015M580214) ; Scientific and Technological Research and Development Program of Qinhuangdao City(201502A006) ; 21473208 ; 91434103 ; 8140287)
WOS记录号WOS:000377150400010
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被引频次:80[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/21155
专题生化工程国家重点实验室
作者单位1.Yanshan Univ, State Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Peoples R China
2.Yanshan Univ, Sch Environm & Chem Engn, Hebei Key Lab Appl Chem, Qinhuangdao 066004, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China
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Zhang, Ruiyun,Xing, Ruirui,Jiao, Tifeng,et al. Carrier-Free, Chemophotodynamic Dual Nanodrugs via Self-Assembly for Synergistic Antitumor Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(21):13262-13269.
APA Zhang, Ruiyun.,Xing, Ruirui.,Jiao, Tifeng.,Ma, Kai.,Chen, Chengjun.,...&Yan, Xuehai.(2016).Carrier-Free, Chemophotodynamic Dual Nanodrugs via Self-Assembly for Synergistic Antitumor Therapy.ACS APPLIED MATERIALS & INTERFACES,8(21),13262-13269.
MLA Zhang, Ruiyun,et al."Carrier-Free, Chemophotodynamic Dual Nanodrugs via Self-Assembly for Synergistic Antitumor Therapy".ACS APPLIED MATERIALS & INTERFACES 8.21(2016):13262-13269.
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