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Carrier-Free, Chemophotodynamic Dual Nanodrugs via Self-Assembly for Synergistic Antitumor Therapy
Zhang, Ruiyun1,2; Xing, Ruirui1,2,3; Jiao, Tifeng1,2; Ma, Kai1,2; Chen, Chengjun3,4; Ma, Guanghui3; Yan, Xuehai3,4
AbstractThere are tremendous challenges from both tumor and its therapeutic formulations affecting the effective treatment of tumor, including tumor recurrence, and complex multistep preparations of formulation. To address these issues, herein a simple and green approach based on the self-assembly of therapeutic agents including a photosensitizer (chlorine e6, Ce6) and a chemotherapeutic agent (doxorubicin, DOX) was developed to prepare carrier free nanoparticles (NPs) with the ability to inhibit tumor recurrence. The designed NPs were formed by self-assembly of Ce6 and DOX associated with electrostatic, pi-pi stacking and hydrophobic interactions. They have a relatively uniform size of average 70 nm, surface charge of -20 mV and high drug encapsulation efficiency, which benefits the favorable accumulation of drugs at the tumor region through a potential enhanced permeability and retention (EPR) effect as compared to their counterpart of free Ce6 solution. In addition, they could eradiate tumors without recurrence in a synergistic way following one treatment cycle. Furthermore, the NPs are safe without any activation of inflammation or immune response in separated organs. Taken together, the rationale of these pure nanodrugs via the self-assembly approach might open an alternative avenue and give inspiration to fabricate new carrier-free nanodrugs for tumor theranostics, especially for two small molecular antitumor drugs with the aim of combinational antitumor therapy in a synergistic way.
KeywordNanodrugs Self-assembly Codelivery Photodynamic Therapy Antitumor Therapy
WOS HeadingsScience & Technology ; Technology
Indexed BySCI
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China(21522307 ; Beijing Natural Science Foundation(7154220) ; Youth Innovation Promotion Association CAS ; CAS visiting professorships for senior international scientists(2016VTA042) ; Chinese Academy of Sciences (CAS) ; Natural Science Foundation of China(21473153) ; Science Foundation for the Excellent Youth Scholars from Universities and Colleges of Hebei Province(YQ2013026) ; Support Program for the Top Young Talents of Hebei Province ; Postgraduate's Innovation Fund Project of Hebei Province(2016SJBS009) ; China Postdoctoral Science Foundation(2015M580214) ; Scientific and Technological Research and Development Program of Qinhuangdao City(201502A006) ; 21473208 ; 91434103 ; 8140287)
WOS IDWOS:000377150400010
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Cited Times:157[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Affiliation1.Yanshan Univ, State Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Peoples R China
2.Yanshan Univ, Sch Environm & Chem Engn, Hebei Key Lab Appl Chem, Qinhuangdao 066004, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Ruiyun,Xing, Ruirui,Jiao, Tifeng,et al. Carrier-Free, Chemophotodynamic Dual Nanodrugs via Self-Assembly for Synergistic Antitumor Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(21):13262-13269.
APA Zhang, Ruiyun.,Xing, Ruirui.,Jiao, Tifeng.,Ma, Kai.,Chen, Chengjun.,...&Yan, Xuehai.(2016).Carrier-Free, Chemophotodynamic Dual Nanodrugs via Self-Assembly for Synergistic Antitumor Therapy.ACS APPLIED MATERIALS & INTERFACES,8(21),13262-13269.
MLA Zhang, Ruiyun,et al."Carrier-Free, Chemophotodynamic Dual Nanodrugs via Self-Assembly for Synergistic Antitumor Therapy".ACS APPLIED MATERIALS & INTERFACES 8.21(2016):13262-13269.
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