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The Construction of an Aqueous Two-Phase System to Solve Weak-Aggregation of Gigaporous Poly(Styrene-Divinyl Benzene) Microspheres
Zhang, Donglai1,2; Zhou, Weiqing1; Li, Juan1; Mi, Yace1,2; Su, Zhiguo1; Ma, Guanghui1
2016-05-01
Source PublicationPOLYMERS
ISSN2073-4360
Volume8Issue:5Pages:142
AbstractGigaporous poly(styrene-divinyl benzene) microspheres made via the surfactant reverse micelles swelling method had a controllable pore size of 100-500 nm. These microspheres had unique advantages in biomacromolecule separation and enzymes immobilization. However, the obtained microspheres adhered to each other in the preparation process. Though the weak aggregation could be re-dispersed easily by mechanical force, it will be difficult to scale up. By analyzing the formation mechanism of the aggregates, a method was presented to rebuild the interface between the internal aqueous channel and the external continuous phase by constructing an aqueous two-phase system (ATPS). Based on the ATPS, the method of emulsification, stirring speed, and surfactant concentration in oil phase were optimized. Under the optimum condition (screen emulsification method, 120 rpm for polymerization and 55% surfactant), the microspheres with a controllable particle size of 10-40 m and a pore size of about 150 nm were obtained. This new method could significantly decrease the weak-aggregation of microspheres.
KeywordGigaporous Microspheres Weak-aggregation Aqueous Two-phase System
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.3390/polym8050142
Indexed BySCI
Language英语
WOS KeywordMEMBRANE EMULSIFICATION TECHNIQUE ; MICELLES SWELLING METHOD ; COMPOSITE MICROSPHERES ; BINDING-CAPACITY ; PORE STRUCTURE ; PARTICLES ; EMULSION ; CHROMATOGRAPHY ; MEDIA ; POLYMERIZATION
WOS Research AreaPolymer Science
WOS SubjectPolymer Science
Funding OrganizationNational Natural Science Foundation of China(21336010) ; National Science and Technology Support Program(2012AA02A406)
WOS IDWOS:000377795200002
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/21160
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Donglai,Zhou, Weiqing,Li, Juan,et al. The Construction of an Aqueous Two-Phase System to Solve Weak-Aggregation of Gigaporous Poly(Styrene-Divinyl Benzene) Microspheres[J]. POLYMERS,2016,8(5):142.
APA Zhang, Donglai,Zhou, Weiqing,Li, Juan,Mi, Yace,Su, Zhiguo,&Ma, Guanghui.(2016).The Construction of an Aqueous Two-Phase System to Solve Weak-Aggregation of Gigaporous Poly(Styrene-Divinyl Benzene) Microspheres.POLYMERS,8(5),142.
MLA Zhang, Donglai,et al."The Construction of an Aqueous Two-Phase System to Solve Weak-Aggregation of Gigaporous Poly(Styrene-Divinyl Benzene) Microspheres".POLYMERS 8.5(2016):142.
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