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Co-Assembly of Graphene Oxide and Albumin/Photosensitizer Nanohybrids towards Enhanced Photodynamic Therapy
Xing, Ruirui1,2,3; Jiao, Tifeng1,2; Liu, Yamei1,2; Ma, Kai1,2; Zou, Qianli3,4; Ma, Guanghui3; Yan, Xuehai3,4
2016-05-01
发表期刊POLYMERS
ISSN2073-4360
卷号8期号:5页码:181
摘要The inactivation of photosensitizers before they reach the targeted tissues can be an important factor, which limits the efficacy of photodynamic therapy (PDT). Here, we developed co-assembled nanohybrids of graphene oxide (GO) and albumin/photosensitizer that have a potential for protecting the photosensitizers from the environment and releasing them in targeted sites, allowing for an enhanced PDT. The nanohybrids were prepared by loading the pre-assembled nanoparticles of chlorin e6 (Ce6) and bovine serum albumin (BSA) on GO via non-covalent interactions. The protection to Ce6 is evident from the inhibited fluorescence and singlet oxygen generation activities of Ce6-BSA-GO nanohybrids. Importantly, compared to free Ce6 and Ce6 directly loaded by GO (Ce6-GO), Ce6-BSA-GO nanohybrids showed enhanced cellular uptake and in vitro release of Ce6, leading to an improved PDT efficiency. These results indicate that the smart photosensitizer delivery system constructed by co-assembly of GO and albumin is promising to improve the stability, biocompatibility, and efficiency of PDT.
关键词Protein Graphene Oxide Singlet Oxygen Generation Co-assembly Photodynamic Therapy
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
DOI10.3390/polym8050181
收录类别SCI
语种英语
关键词[WOS]BOVINE SERUM-ALBUMIN ; DRUG-DELIVERY ; NANOPARTICLES ; DESIGN ; NANOARCHITECTONICS ; PHOTOSENSITIZER ; DEGRADATION ; LIFETIME ; PROBE ; FILMS
WOS研究方向Polymer Science
WOS类目Polymer Science
项目资助者National Natural Science Foundation of China(21522307 ; Talent Fund of the Recruitment Program of Global Youth Experts ; CAS(2016VTA042) ; Chinese Academy of Sciences (CAS) ; Natural Science Foundation of China(21473153) ; Science Foundation for the Excellent Youth Scholars from Universities and Colleges of Hebei Province(YQ2013026) ; Support Program for the Top Young Talents of Hebei Province ; Post-graduate's Innovation Fund Project of Hebei Province(2016SJBS009) ; China Postdoctoral Science Foundation(2015M580214) ; Scientific and Technological Research and Development Program of Qinhuangdao City(201502A006) ; 21473208 ; 91434103 ; 51403214)
WOS记录号WOS:000377795200021
引用统计
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/21166
专题生化工程国家重点实验室
作者单位1.Yanshan Univ, State Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Peoples R China
2.Yanshan Univ, Sch Environm & Chem Engn, Hebei Key Lab Appl Chem, Qinhuangdao 066004, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China
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Xing, Ruirui,Jiao, Tifeng,Liu, Yamei,et al. Co-Assembly of Graphene Oxide and Albumin/Photosensitizer Nanohybrids towards Enhanced Photodynamic Therapy[J]. POLYMERS,2016,8(5):181.
APA Xing, Ruirui.,Jiao, Tifeng.,Liu, Yamei.,Ma, Kai.,Zou, Qianli.,...&Yan, Xuehai.(2016).Co-Assembly of Graphene Oxide and Albumin/Photosensitizer Nanohybrids towards Enhanced Photodynamic Therapy.POLYMERS,8(5),181.
MLA Xing, Ruirui,et al."Co-Assembly of Graphene Oxide and Albumin/Photosensitizer Nanohybrids towards Enhanced Photodynamic Therapy".POLYMERS 8.5(2016):181.
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