CAS OpenIR  > 生化工程国家重点实验室
Co-Assembly of Graphene Oxide and Albumin/Photosensitizer Nanohybrids towards Enhanced Photodynamic Therapy
Xing, Ruirui1,2,3; Jiao, Tifeng1,2; Liu, Yamei1,2; Ma, Kai1,2; Zou, Qianli3,4; Ma, Guanghui3; Yan, Xuehai3,4
2016-05-01
Source PublicationPOLYMERS
ISSN2073-4360
Volume8Issue:5Pages:181
AbstractThe inactivation of photosensitizers before they reach the targeted tissues can be an important factor, which limits the efficacy of photodynamic therapy (PDT). Here, we developed co-assembled nanohybrids of graphene oxide (GO) and albumin/photosensitizer that have a potential for protecting the photosensitizers from the environment and releasing them in targeted sites, allowing for an enhanced PDT. The nanohybrids were prepared by loading the pre-assembled nanoparticles of chlorin e6 (Ce6) and bovine serum albumin (BSA) on GO via non-covalent interactions. The protection to Ce6 is evident from the inhibited fluorescence and singlet oxygen generation activities of Ce6-BSA-GO nanohybrids. Importantly, compared to free Ce6 and Ce6 directly loaded by GO (Ce6-GO), Ce6-BSA-GO nanohybrids showed enhanced cellular uptake and in vitro release of Ce6, leading to an improved PDT efficiency. These results indicate that the smart photosensitizer delivery system constructed by co-assembly of GO and albumin is promising to improve the stability, biocompatibility, and efficiency of PDT.
KeywordProtein Graphene Oxide Singlet Oxygen Generation Co-assembly Photodynamic Therapy
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.3390/polym8050181
Indexed BySCI
Language英语
WOS KeywordBOVINE SERUM-ALBUMIN ; DRUG-DELIVERY ; NANOPARTICLES ; DESIGN ; NANOARCHITECTONICS ; PHOTOSENSITIZER ; DEGRADATION ; LIFETIME ; PROBE ; FILMS
WOS Research AreaPolymer Science
WOS SubjectPolymer Science
Funding OrganizationNational Natural Science Foundation of China(21522307 ; Talent Fund of the Recruitment Program of Global Youth Experts ; CAS(2016VTA042) ; Chinese Academy of Sciences (CAS) ; Natural Science Foundation of China(21473153) ; Science Foundation for the Excellent Youth Scholars from Universities and Colleges of Hebei Province(YQ2013026) ; Support Program for the Top Young Talents of Hebei Province ; Post-graduate's Innovation Fund Project of Hebei Province(2016SJBS009) ; China Postdoctoral Science Foundation(2015M580214) ; Scientific and Technological Research and Development Program of Qinhuangdao City(201502A006) ; 21473208 ; 91434103 ; 51403214)
WOS IDWOS:000377795200021
Citation statistics
Cited Times:84[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/21166
Collection生化工程国家重点实验室
Affiliation1.Yanshan Univ, State Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Peoples R China
2.Yanshan Univ, Sch Environm & Chem Engn, Hebei Key Lab Appl Chem, Qinhuangdao 066004, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Xing, Ruirui,Jiao, Tifeng,Liu, Yamei,et al. Co-Assembly of Graphene Oxide and Albumin/Photosensitizer Nanohybrids towards Enhanced Photodynamic Therapy[J]. POLYMERS,2016,8(5):181.
APA Xing, Ruirui.,Jiao, Tifeng.,Liu, Yamei.,Ma, Kai.,Zou, Qianli.,...&Yan, Xuehai.(2016).Co-Assembly of Graphene Oxide and Albumin/Photosensitizer Nanohybrids towards Enhanced Photodynamic Therapy.POLYMERS,8(5),181.
MLA Xing, Ruirui,et al."Co-Assembly of Graphene Oxide and Albumin/Photosensitizer Nanohybrids towards Enhanced Photodynamic Therapy".POLYMERS 8.5(2016):181.
Files in This Item:
File Name/Size DocType Version Access License
Co-Assembly of Graph(2264KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Xing, Ruirui]'s Articles
[Jiao, Tifeng]'s Articles
[Liu, Yamei]'s Articles
Baidu academic
Similar articles in Baidu academic
[Xing, Ruirui]'s Articles
[Jiao, Tifeng]'s Articles
[Liu, Yamei]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Xing, Ruirui]'s Articles
[Jiao, Tifeng]'s Articles
[Liu, Yamei]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.