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Interfacial Cohesion and Assembly of Bioadhesive Molecules for Design of Long Term Stable Hydrophobic Nanodrugs toward Effective Anticancer Therapy
Shen, Guizhi1,2; Xing, Ruirui1,2; Zhang, Ning1; Chen, Chengjun1; Ma, Guanghui1; Yan, Xuehai1,2
2016-06-01
Source PublicationACS NANO
ISSN1936-0851
Volume10Issue:6Pages:5720-5729
AbstractThe majority of anticancer drugs are poorly water-soluble and thus suffer from rather low bioavailability. Although a variety of delivery carriers have been developed for bioavailability improvement, they are severely limited by low drug loading and undesired side effects. The optimum delivery vehicle would be a biocompatible and biodegradable drug nanoparticle of uniform size with a thin but stable shell, making it soluble, preventing aggregation and enabling targeting. Here, we present a general strategy for the rational design of hydrophobic drug nanoparticles with high drug loading by means of interfacial cohesion and supramolecular assembly of bioadhesive species. We demonstrate that the pathway is capable of effectively suppressing and retarding Ostwald ripening, providing drug nanoparticles with small and uniform size and long-term colloidal stability. The final complex drug nanoparticles provide higher tumor accumulation, negligible toxicity, and enhanced antitumor activity, superior to commercial formulations. Our findings demonstrate that local, on-demand coating of hydrophobic nanoparticles is achievable through cooperation and compromise of interfacial adhesion and assembly.
KeywordHydrophobic Drugs Nanoengineering Interfacial Assembly Ostwald Ripening Suppression Drug Delivery
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
DOI10.1021/acsnano.5b07276
Indexed BySCI
Language英语
WOS KeywordDRUG-DELIVERY ; CANCER-THERAPY ; POLYMERIC MICELLES ; TANNIC-ACID ; NANOPARTICLES ; NANOMEDICINE ; CAPSULES ; SIZE ; IRON ; NANOARCHITECTONICS
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China(21522307 ; Talent Fund of the Recruitment Program of Global Youth Experts ; Beijing Natural Science Foundation(7154220) ; CAS(2016VTA042) ; Chinese Academy of Sciences (CAS) ; 21473208 ; 91434103 ; 81402871)
WOS IDWOS:000378973700015
Citation statistics
Cited Times:54[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/21170
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Shen, Guizhi,Xing, Ruirui,Zhang, Ning,et al. Interfacial Cohesion and Assembly of Bioadhesive Molecules for Design of Long Term Stable Hydrophobic Nanodrugs toward Effective Anticancer Therapy[J]. ACS NANO,2016,10(6):5720-5729.
APA Shen, Guizhi,Xing, Ruirui,Zhang, Ning,Chen, Chengjun,Ma, Guanghui,&Yan, Xuehai.(2016).Interfacial Cohesion and Assembly of Bioadhesive Molecules for Design of Long Term Stable Hydrophobic Nanodrugs toward Effective Anticancer Therapy.ACS NANO,10(6),5720-5729.
MLA Shen, Guizhi,et al."Interfacial Cohesion and Assembly of Bioadhesive Molecules for Design of Long Term Stable Hydrophobic Nanodrugs toward Effective Anticancer Therapy".ACS NANO 10.6(2016):5720-5729.
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