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题名:
Interfacial Cohesion and Assembly of Bioadhesive Molecules for Design of Long Term Stable Hydrophobic Nanodrugs toward Effective Anticancer Therapy
作者: Shen, Guizhi1,2; Xing, Ruirui1,2; Zhang, Ning1; Chen, Chengjun1; Ma, Guanghui1; Yan, Xuehai1,2
刊名: ACS NANO
出版日期: 2016-06-01
卷号: 10, 期号:6, 页码:5720-5729
关键词: hydrophobic drugs ; nanoengineering ; interfacial assembly ; Ostwald ripening suppression ; drug delivery
收录类别: SCI
WOS记录号: WOS:000378973700015
DOI: 10.1021/acsnano.5b07276
文章类型: Article
英文摘要: The majority of anticancer drugs are poorly water-soluble and thus suffer from rather low bioavailability. Although a variety of delivery carriers have been developed for bioavailability improvement, they are severely limited by low drug loading and undesired side effects. The optimum delivery vehicle would be a biocompatible and biodegradable drug nanoparticle of uniform size with a thin but stable shell, making it soluble, preventing aggregation and enabling targeting. Here, we present a general strategy for the rational design of hydrophobic drug nanoparticles with high drug loading by means of interfacial cohesion and supramolecular assembly of bioadhesive species. We demonstrate that the pathway is capable of effectively suppressing and retarding Ostwald ripening, providing drug nanoparticles with small and uniform size and long-term colloidal stability. The final complex drug nanoparticles provide higher tumor accumulation, negligible toxicity, and enhanced antitumor activity, superior to commercial formulations. Our findings demonstrate that local, on-demand coating of hydrophobic nanoparticles is achievable through cooperation and compromise of interfacial adhesion and assembly.
WOS标题词: Science & Technology ; Physical Sciences ; Technology
类目[WOS]: Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
研究领域[WOS]: Chemistry ; Science & Technology - Other Topics ; Materials Science
关键词[WOS]: DRUG-DELIVERY ; CANCER-THERAPY ; POLYMERIC MICELLES ; TANNIC-ACID ; NANOPARTICLES ; NANOMEDICINE ; CAPSULES ; SIZE ; IRON ; NANOARCHITECTONICS
项目资助者: National Natural Science Foundation of China(21522307 ; Talent Fund of the Recruitment Program of Global Youth Experts ; Beijing Natural Science Foundation(7154220) ; CAS(2016VTA042) ; Chinese Academy of Sciences (CAS) ; 21473208 ; 91434103 ; 81402871)
语种: 英语
ISSN号: 1936-0851
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.ipe.ac.cn/handle/122111/21170
Appears in Collections:生化工程国家重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China

Recommended Citation:
Shen, Guizhi,Xing, Ruirui,Zhang, Ning,et al. Interfacial Cohesion and Assembly of Bioadhesive Molecules for Design of Long Term Stable Hydrophobic Nanodrugs toward Effective Anticancer Therapy[J]. ACS NANO,2016,10(6):5720-5729.
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