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Interfacial Cohesion and Assembly of Bioadhesive Molecules for Design of Long Term Stable Hydrophobic Nanodrugs toward Effective Anticancer Therapy
Shen, Guizhi1,2; Xing, Ruirui1,2; Zhang, Ning1; Chen, Chengjun1; Ma, Guanghui1; Yan, Xuehai1,2
2016-06-01
发表期刊ACS NANO
ISSN1936-0851
卷号10期号:6页码:5720-5729
摘要The majority of anticancer drugs are poorly water-soluble and thus suffer from rather low bioavailability. Although a variety of delivery carriers have been developed for bioavailability improvement, they are severely limited by low drug loading and undesired side effects. The optimum delivery vehicle would be a biocompatible and biodegradable drug nanoparticle of uniform size with a thin but stable shell, making it soluble, preventing aggregation and enabling targeting. Here, we present a general strategy for the rational design of hydrophobic drug nanoparticles with high drug loading by means of interfacial cohesion and supramolecular assembly of bioadhesive species. We demonstrate that the pathway is capable of effectively suppressing and retarding Ostwald ripening, providing drug nanoparticles with small and uniform size and long-term colloidal stability. The final complex drug nanoparticles provide higher tumor accumulation, negligible toxicity, and enhanced antitumor activity, superior to commercial formulations. Our findings demonstrate that local, on-demand coating of hydrophobic nanoparticles is achievable through cooperation and compromise of interfacial adhesion and assembly.
关键词Hydrophobic Drugs Nanoengineering Interfacial Assembly Ostwald Ripening Suppression Drug Delivery
文章类型Article
WOS标题词Science & Technology ; Physical Sciences ; Technology
DOI10.1021/acsnano.5b07276
收录类别SCI
语种英语
关键词[WOS]DRUG-DELIVERY ; CANCER-THERAPY ; POLYMERIC MICELLES ; TANNIC-ACID ; NANOPARTICLES ; NANOMEDICINE ; CAPSULES ; SIZE ; IRON ; NANOARCHITECTONICS
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
项目资助者National Natural Science Foundation of China(21522307 ; Talent Fund of the Recruitment Program of Global Youth Experts ; Beijing Natural Science Foundation(7154220) ; CAS(2016VTA042) ; Chinese Academy of Sciences (CAS) ; 21473208 ; 91434103 ; 81402871)
WOS记录号WOS:000378973700015
引用统计
被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/21170
专题生化工程国家重点实验室
作者单位1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China
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Shen, Guizhi,Xing, Ruirui,Zhang, Ning,et al. Interfacial Cohesion and Assembly of Bioadhesive Molecules for Design of Long Term Stable Hydrophobic Nanodrugs toward Effective Anticancer Therapy[J]. ACS NANO,2016,10(6):5720-5729.
APA Shen, Guizhi,Xing, Ruirui,Zhang, Ning,Chen, Chengjun,Ma, Guanghui,&Yan, Xuehai.(2016).Interfacial Cohesion and Assembly of Bioadhesive Molecules for Design of Long Term Stable Hydrophobic Nanodrugs toward Effective Anticancer Therapy.ACS NANO,10(6),5720-5729.
MLA Shen, Guizhi,et al."Interfacial Cohesion and Assembly of Bioadhesive Molecules for Design of Long Term Stable Hydrophobic Nanodrugs toward Effective Anticancer Therapy".ACS NANO 10.6(2016):5720-5729.
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