Gadolinium polytungstate nanoclusters: a new theranostic with ultrasmall size and versatile properties for dual-modal MR/CT imaging and photothermal therapy/radiotherapy of cancer
Yong, Yuan1,2; Zhou, Liangjun1,2; Zhang, Shuangshuang3; Yan, Liang1,2; Gu, Zhanjun1,2; Zhang, Guangjin3; Zhao, Yuliang1,2
2016-05-01
发表期刊NPG ASIA MATERIALS
ISSN1884-4049
卷号8期号:8页码:e273
摘要The development of a new generation of nanoscaled theranostics with simple compositions and versatile properties to realize enhanced diagnoses and treatment outcomes and to avoid side effects is highly desirable but remains a great challenge. Here we report a new ultrasmall theranostic based on bovine serum albumin-coated GdW10O36 nanoclusters (GdW10NCs) as multifunctional theranostics for multifunctional bio-imaging, highly effective in vitro photothermal ablation of cancer cells and in vivo radiotherapy of tumors. The as-synthesized GdW10 NCs afford significantly enhanced computed tomography/magnetic resonance imaging signals and remarkable photothermal therapy (PTT)/radiotherapy therapy (RT) therapeutic effects for tumor treatment. Moreover, toxicity studies confirmed their low toxicity and efficient renal clearance, suggesting their potential for practical applications. These results indicated that the as-prepared GdW10 nanoclusters are promising as multifunctional nanotheranostics for multimodal imaging-guided PTT/RT of tumors. These results also encourage the further exploration of other polyoxometalate-based multifunctional nanotheranostics for cancer diagnoses and therapy.
文章类型Article
WOS标题词Science & Technology ; Technology
DOI10.1038/am.2016.63
收录类别SCI
语种英语
关键词[WOS]MRI CONTRAST AGENTS ; APOPTOTIC CELL-DEATH ; BOVINE SERUM-ALBUMIN ; DRUG-DELIVERY ; IN-VITRO ; SYNERGISTIC THERAPY ; GRAPHENE ANALOGS ; POLYOXOMETALATE ; NANOPARTICLES ; COMPLEXES
WOS研究方向Materials Science
WOS类目Materials Science, Multidisciplinary
项目资助者National Basic Research Programs of China (973 programs)(2012CB932500 ; NSFC(21177128 ; 2015CB932104) ; 31751015 ; 21371173 ; 21320102003)
WOS记录号WOS:000379759400006
引用统计
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/21231
专题湿法冶金清洁生产技术国家工程实验室
作者单位1.Chinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Inst High Energy Phys, Yuquan Rd 19b Shijingshan Dist, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Natl Ctr Nanosci & Technol China, Yuquan Rd 19b Shijingshan Dist, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, Zhongguancun South Rd 12 Haidian Dist, Beijing 100190, Peoples R China
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Yong, Yuan,Zhou, Liangjun,Zhang, Shuangshuang,et al. Gadolinium polytungstate nanoclusters: a new theranostic with ultrasmall size and versatile properties for dual-modal MR/CT imaging and photothermal therapy/radiotherapy of cancer[J]. NPG ASIA MATERIALS,2016,8(8):e273.
APA Yong, Yuan.,Zhou, Liangjun.,Zhang, Shuangshuang.,Yan, Liang.,Gu, Zhanjun.,...&Zhao, Yuliang.(2016).Gadolinium polytungstate nanoclusters: a new theranostic with ultrasmall size and versatile properties for dual-modal MR/CT imaging and photothermal therapy/radiotherapy of cancer.NPG ASIA MATERIALS,8(8),e273.
MLA Yong, Yuan,et al."Gadolinium polytungstate nanoclusters: a new theranostic with ultrasmall size and versatile properties for dual-modal MR/CT imaging and photothermal therapy/radiotherapy of cancer".NPG ASIA MATERIALS 8.8(2016):e273.
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