CAS OpenIR  > 湿法冶金清洁生产技术国家工程实验室
Gadolinium polytungstate nanoclusters: a new theranostic with ultrasmall size and versatile properties for dual-modal MR/CT imaging and photothermal therapy/radiotherapy of cancer
Yong, Yuan1,2; Zhou, Liangjun1,2; Zhang, Shuangshuang3; Yan, Liang1,2; Gu, Zhanjun1,2; Zhang, Guangjin3; Zhao, Yuliang1,2
2016-05-01
Source PublicationNPG ASIA MATERIALS
ISSN1884-4049
Volume8Issue:8Pages:e273
AbstractThe development of a new generation of nanoscaled theranostics with simple compositions and versatile properties to realize enhanced diagnoses and treatment outcomes and to avoid side effects is highly desirable but remains a great challenge. Here we report a new ultrasmall theranostic based on bovine serum albumin-coated GdW10O36 nanoclusters (GdW10NCs) as multifunctional theranostics for multifunctional bio-imaging, highly effective in vitro photothermal ablation of cancer cells and in vivo radiotherapy of tumors. The as-synthesized GdW10 NCs afford significantly enhanced computed tomography/magnetic resonance imaging signals and remarkable photothermal therapy (PTT)/radiotherapy therapy (RT) therapeutic effects for tumor treatment. Moreover, toxicity studies confirmed their low toxicity and efficient renal clearance, suggesting their potential for practical applications. These results indicated that the as-prepared GdW10 nanoclusters are promising as multifunctional nanotheranostics for multimodal imaging-guided PTT/RT of tumors. These results also encourage the further exploration of other polyoxometalate-based multifunctional nanotheranostics for cancer diagnoses and therapy.
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
DOI10.1038/am.2016.63
Indexed BySCI
Language英语
WOS KeywordMRI CONTRAST AGENTS ; APOPTOTIC CELL-DEATH ; BOVINE SERUM-ALBUMIN ; DRUG-DELIVERY ; IN-VITRO ; SYNERGISTIC THERAPY ; GRAPHENE ANALOGS ; POLYOXOMETALATE ; NANOPARTICLES ; COMPLEXES
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Multidisciplinary
Funding OrganizationNational Basic Research Programs of China (973 programs)(2012CB932500 ; NSFC(21177128 ; 2015CB932104) ; 31751015 ; 21371173 ; 21320102003)
WOS IDWOS:000379759400006
Citation statistics
Cited Times:42[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/21231
Collection湿法冶金清洁生产技术国家工程实验室
Affiliation1.Chinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Inst High Energy Phys, Yuquan Rd 19b Shijingshan Dist, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Natl Ctr Nanosci & Technol China, Yuquan Rd 19b Shijingshan Dist, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, Zhongguancun South Rd 12 Haidian Dist, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Yong, Yuan,Zhou, Liangjun,Zhang, Shuangshuang,et al. Gadolinium polytungstate nanoclusters: a new theranostic with ultrasmall size and versatile properties for dual-modal MR/CT imaging and photothermal therapy/radiotherapy of cancer[J]. NPG ASIA MATERIALS,2016,8(8):e273.
APA Yong, Yuan.,Zhou, Liangjun.,Zhang, Shuangshuang.,Yan, Liang.,Gu, Zhanjun.,...&Zhao, Yuliang.(2016).Gadolinium polytungstate nanoclusters: a new theranostic with ultrasmall size and versatile properties for dual-modal MR/CT imaging and photothermal therapy/radiotherapy of cancer.NPG ASIA MATERIALS,8(8),e273.
MLA Yong, Yuan,et al."Gadolinium polytungstate nanoclusters: a new theranostic with ultrasmall size and versatile properties for dual-modal MR/CT imaging and photothermal therapy/radiotherapy of cancer".NPG ASIA MATERIALS 8.8(2016):e273.
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