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A rapid, non-invasive and non-destructive method for studying swelling behavior and microstructure variations of hydrogels
Li, Yaqiong1; Li, Xiunan2; Chen, Chao2; Zhao, Dawei2; Su, Zhiguo2,3; Ma, Guanghui2; Yu, Rong1
2016-10-20
Source PublicationCARBOHYDRATE POLYMERS
ISSN0144-8617
Volume151Issue:OCTPages:1251-1260
AbstractA new method for studying swelling behavior of hydrogels was developed based on low field NMR (LFNMR). This method is established on these facts: firstly, internal water (water trapped in hydrogel) and external water (water outside of hydrogel) correspond to different components of transverse relaxation time (T-2); secondly, T-2 component amplitude is proportional to relative water content; and finally, T-2 value is closely related to mesh size of hydrogel network, the main effect being due to the overall concentration (degree of swelling). This method was successfully applied to swelling ratio determination of chitosan/glutaraldehyde (CS/GA) hydrogels in situ, and the results had better accuracy and repeatability compared with that of weighing method. Furthermore, swelling kinetics at different pH and microstructure of CS/GA hydrogels was well elucidated based on T-2. It is clearly showed that LF-NMR provides a powerful tool for probing processes related to water transport and microstructure variation of hydrogels. (C) 2016 Elsevier Ltd. All rights reserved.
KeywordHydrogels Swelling Lf-nmr T-2 Microstructure
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1016/j.carbpol.2016.06.054
Indexed BySCI
Language英语
WOS KeywordCONTROLLED-RELEASE ; WATER MOBILITY ; NMR RELAXATION ; DRUG-DELIVERY ; LUNG INJURY ; CHITOSAN ; PROTEIN ; GELATINIZATION ; DYNAMICS ; PH
WOS Research AreaChemistry ; Polymer Science
WOS SubjectChemistry, Applied ; Chemistry, Organic ; Polymer Science
Funding OrganizationNational High Technology Research and Development Program of China (863 Program)(2014AA021005 ; National Natural Science Foundation of China(21376248 ; National Key Scientific Instrument and Equipment Development Project(2013YQ14040508) ; Doctoral Fund of the Ministry of Education(20120181110036) ; Opening Foundation of National Key Laboratory of Biochemical Engineering(2014KF-4) ; 2014AA021006) ; 21506228)
WOS IDWOS:000380943900142
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Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/21288
Collection生化工程国家重点实验室
Affiliation1.Sichuan Univ, West China Sch Pharm, Minist Educ, Key Lab Drug Targeting & Drug Delivery Syst, Chengdu 610041, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Nanjing 210023, Jiangsu, Peoples R China
Recommended Citation
GB/T 7714
Li, Yaqiong,Li, Xiunan,Chen, Chao,et al. A rapid, non-invasive and non-destructive method for studying swelling behavior and microstructure variations of hydrogels[J]. CARBOHYDRATE POLYMERS,2016,151(OCT):1251-1260.
APA Li, Yaqiong.,Li, Xiunan.,Chen, Chao.,Zhao, Dawei.,Su, Zhiguo.,...&Yu, Rong.(2016).A rapid, non-invasive and non-destructive method for studying swelling behavior and microstructure variations of hydrogels.CARBOHYDRATE POLYMERS,151(OCT),1251-1260.
MLA Li, Yaqiong,et al."A rapid, non-invasive and non-destructive method for studying swelling behavior and microstructure variations of hydrogels".CARBOHYDRATE POLYMERS 151.OCT(2016):1251-1260.
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