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Protein kinase A inhibitor, H89, significantly enhances survival rate of dissociated human embryonic stem cells following cryopreservation
Zhang, Liang1,2; Xu, Yanqing1; Xu, Jiandong1; Wei, Yuping1; Xu, Xia1
2016-10-01
Source PublicationCELL PROLIFERATION
ISSN0960-7722
Volume49Issue:5Pages:589-598
Abstract

ObjectivesHuman embryonic stem cells (hESCs) have huge potential for establishment of disease models and for treating degenerative diseases. However, the extremely low survival level of dissociated hESCs following cryopreservation is been a tremendous problem to allow for their rapid expansion, genetic manipulation and future medical applications. In this study, we have aimed to develop an efficient strategy to improve survival of dissociated hESCs after cryopreservation.

SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1111/cpr.12278
Indexed BySCI
Language英语
WOS KeywordROCK INHIBITOR ; EFFICIENT CRYOPRESERVATION ; DEPENDENT APOPTOSIS ; HUMAN BLASTOCYSTS ; SELF-RENEWAL ; FREEZE-THAW ; DIFFERENTIATION ; EXPRESSION ; CULTURE ; MATRIX
WOS Research AreaCell Biology
WOS SubjectCell Biology
Funding OrganizationNational Natural Science Foundation of China(21176238 ; 21576266)
WOS IDWOS:000383766400006
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/21334
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Liang,Xu, Yanqing,Xu, Jiandong,et al. Protein kinase A inhibitor, H89, significantly enhances survival rate of dissociated human embryonic stem cells following cryopreservation[J]. CELL PROLIFERATION,2016,49(5):589-598.
APA Zhang, Liang,Xu, Yanqing,Xu, Jiandong,Wei, Yuping,&Xu, Xia.(2016).Protein kinase A inhibitor, H89, significantly enhances survival rate of dissociated human embryonic stem cells following cryopreservation.CELL PROLIFERATION,49(5),589-598.
MLA Zhang, Liang,et al."Protein kinase A inhibitor, H89, significantly enhances survival rate of dissociated human embryonic stem cells following cryopreservation".CELL PROLIFERATION 49.5(2016):589-598.
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