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Comparative evaluation of a biomimic collagen/hydroxyapatite/beta-tricaleium phosphate scaffold in alveolar ridge preservation with Bio-Oss Collagen
Wang, Tong1; Li, Qing1,2,3; Zhang, Gui-feng4; Zhou, Gang5; Yu, Xin5; Zhang, Jing5; Wang, Xiu-mei6; Tang, Zhi-hui1,3
2016-06-01
Source PublicationFRONTIERS OF MATERIALS SCIENCE
ISSN2095-025X
Volume10Issue:2Pages:122-133
Abstract

Bone scaffolds are critical in current implant and periodontal regeneration approaches. In this study, we prepared a novel composite type-I collagen and hydroxyapatite (HA)/beta-tricaleium phosphate (TCP) scaffold (CHTS) by incorporating type-I collagen and bovine calcined bone granules, prepared as a mixture of 50% HA and 50% TCP, by freeze drying. We then characterized the CHTS and determined its cytotoxic effects. Additionally, ridge preservation experiments were carried out to evaluate the clinical effects of the CHTS. The results demonstrated that the composite scaffolds had good surface morphology and no cytotoxicity. Additionally, an in vivo experiment in an animal model showed that the CHTS performed equally as well as Bio-Oss Collagen, a widely used bone graft in ridge preservation. These findings revealed that the CHTS, which contained natural constituents of bone, could be used as a scaffold for bone regeneration and clinical use.

KeywordHydroxyapatite Beta-tricaleium Phosphate (Tcp) Collagen Scaffold Ridge Preservation
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
DOI10.1007/s11706-016-0333-0
Indexed BySCI
Language英语
WOS KeywordBETA-TRICALCIUM PHOSPHATE ; MESENCHYMAL STEM-CELLS ; INDUCE OSTEOGENIC DIFFERENTIATION ; DEPROTEINIZED BOVINE BONE ; CALCIUM-PHOSPHATE ; EXTRACTION SOCKETS ; IMPLANT OSSEOINTEGRATION ; CROSS-LINKING ; IN-VITRO ; REGENERATION
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China (NSFC)(51572144) ; Science Foundation of Beijing Research(Z121100005212009)
WOS IDWOS:000381204500003
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/21424
Collection研究所(批量导入)
Affiliation1.Peking Univ, Dent Ctr 2, Sch & Hosp Stomatol, Beijing 100101, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Ctr Digital Dent, Beijing 100081, Peoples R China
3.Natl Engn Lab Digital & Mat Technol Stomatol, Beijing 100081, Peoples R China
4.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China
5.Beihang Univ, Sch Biol Sci & Med Engn, Key Lab Biomech & Mechnobiol, Minist Educ, Beijing 100191, Peoples R China
6.Tsinghua Univ, Inst Regenerat Biomat, Beijing 100084, Peoples R China
Recommended Citation
GB/T 7714
Wang, Tong,Li, Qing,Zhang, Gui-feng,et al. Comparative evaluation of a biomimic collagen/hydroxyapatite/beta-tricaleium phosphate scaffold in alveolar ridge preservation with Bio-Oss Collagen[J]. FRONTIERS OF MATERIALS SCIENCE,2016,10(2):122-133.
APA Wang, Tong.,Li, Qing.,Zhang, Gui-feng.,Zhou, Gang.,Yu, Xin.,...&Tang, Zhi-hui.(2016).Comparative evaluation of a biomimic collagen/hydroxyapatite/beta-tricaleium phosphate scaffold in alveolar ridge preservation with Bio-Oss Collagen.FRONTIERS OF MATERIALS SCIENCE,10(2),122-133.
MLA Wang, Tong,et al."Comparative evaluation of a biomimic collagen/hydroxyapatite/beta-tricaleium phosphate scaffold in alveolar ridge preservation with Bio-Oss Collagen".FRONTIERS OF MATERIALS SCIENCE 10.2(2016):122-133.
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