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Comparative evaluation of a biomimic collagen/hydroxyapatite/beta-tricaleium phosphate scaffold in alveolar ridge preservation with Bio-Oss Collagen
Wang, Tong1; Li, Qing1,2,3; Zhang, Gui-feng4; Zhou, Gang5; Yu, Xin5; Zhang, Jing5; Wang, Xiu-mei6; Tang, Zhi-hui1,3
2016-06-01
发表期刊FRONTIERS OF MATERIALS SCIENCE
ISSN2095-025X
卷号10期号:2页码:122-133
摘要

Bone scaffolds are critical in current implant and periodontal regeneration approaches. In this study, we prepared a novel composite type-I collagen and hydroxyapatite (HA)/beta-tricaleium phosphate (TCP) scaffold (CHTS) by incorporating type-I collagen and bovine calcined bone granules, prepared as a mixture of 50% HA and 50% TCP, by freeze drying. We then characterized the CHTS and determined its cytotoxic effects. Additionally, ridge preservation experiments were carried out to evaluate the clinical effects of the CHTS. The results demonstrated that the composite scaffolds had good surface morphology and no cytotoxicity. Additionally, an in vivo experiment in an animal model showed that the CHTS performed equally as well as Bio-Oss Collagen, a widely used bone graft in ridge preservation. These findings revealed that the CHTS, which contained natural constituents of bone, could be used as a scaffold for bone regeneration and clinical use.

关键词Hydroxyapatite Beta-tricaleium Phosphate (Tcp) Collagen Scaffold Ridge Preservation
文章类型Article
WOS标题词Science & Technology ; Technology
DOI10.1007/s11706-016-0333-0
收录类别SCI
语种英语
关键词[WOS]BETA-TRICALCIUM PHOSPHATE ; MESENCHYMAL STEM-CELLS ; INDUCE OSTEOGENIC DIFFERENTIATION ; DEPROTEINIZED BOVINE BONE ; CALCIUM-PHOSPHATE ; EXTRACTION SOCKETS ; IMPLANT OSSEOINTEGRATION ; CROSS-LINKING ; IN-VITRO ; REGENERATION
WOS研究方向Materials Science
WOS类目Materials Science, Multidisciplinary
项目资助者National Natural Science Foundation of China (NSFC)(51572144) ; Science Foundation of Beijing Research(Z121100005212009)
WOS记录号WOS:000381204500003
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/21424
专题研究所(批量导入)
作者单位1.Peking Univ, Dent Ctr 2, Sch & Hosp Stomatol, Beijing 100101, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Ctr Digital Dent, Beijing 100081, Peoples R China
3.Natl Engn Lab Digital & Mat Technol Stomatol, Beijing 100081, Peoples R China
4.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China
5.Beihang Univ, Sch Biol Sci & Med Engn, Key Lab Biomech & Mechnobiol, Minist Educ, Beijing 100191, Peoples R China
6.Tsinghua Univ, Inst Regenerat Biomat, Beijing 100084, Peoples R China
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Wang, Tong,Li, Qing,Zhang, Gui-feng,et al. Comparative evaluation of a biomimic collagen/hydroxyapatite/beta-tricaleium phosphate scaffold in alveolar ridge preservation with Bio-Oss Collagen[J]. FRONTIERS OF MATERIALS SCIENCE,2016,10(2):122-133.
APA Wang, Tong.,Li, Qing.,Zhang, Gui-feng.,Zhou, Gang.,Yu, Xin.,...&Tang, Zhi-hui.(2016).Comparative evaluation of a biomimic collagen/hydroxyapatite/beta-tricaleium phosphate scaffold in alveolar ridge preservation with Bio-Oss Collagen.FRONTIERS OF MATERIALS SCIENCE,10(2),122-133.
MLA Wang, Tong,et al."Comparative evaluation of a biomimic collagen/hydroxyapatite/beta-tricaleium phosphate scaffold in alveolar ridge preservation with Bio-Oss Collagen".FRONTIERS OF MATERIALS SCIENCE 10.2(2016):122-133.
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