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A novel strategy for the preparation of porous microspheres and its application in peptide drug loading
Wei, Yi1; Wang, Yuxia1; Zhang, Huixia2; Zhou, Weiqing1; Ma, Guanghui1
2016-09-15
发表期刊JOURNAL OF COLLOID AND INTERFACE SCIENCE
ISSN0021-9797
卷号478期号:SEP页码:46-53
摘要

A new strategy is developed to prepare porous microspheres with narrow size distribution for peptides controlled release, involving a fabrication of porous microspheres without any porogens followed by a pore closing process. Amphiphilic polymers with different hydrophobic segments (poly(monomethoxy-polyethylene glycol-co-D,L-lactide) (mPEG-PLA), poly(monomethoxypolyethylene co-glycolic acid) (mPEG-PLGA)) are employed as microspheres matrix to prepare porous microspheres based on a double emulsion-premix membrane emulsification technique combined with a solvent evaporation method. Both microspheres possess narrow size distribution and porous surface, which are mainly caused by (a) hydrophilic polyethylene glycol (PEG) segments absorbing water molecules followed by a water evaporation process and (b) local explosion of microspheres due to fast evaporation of dichloromethane (MC). Importantly, mPEG-PLGA microspheres have a honeycomb like structure while mPEG-PLA microspheres have a solid structure internally, illustrating that the different hydrophobic segments could modulate the affinity between solvent and matrix polymer and influence the phase separation rate of microspheres matrix. Long term release patterns are demonstrated with pore-closed microspheres, which are prepared from mPEG-PLGA microspheres loading salmon calcitonin (SCT). These results suggest that it is potential to construct porous microspheres for drug sustained release using permanent geometric templates as new porogens. (C) 2016 Elsevier Inc. All rights reserved.

关键词Porous Microspheres Narrow Size Distribution Mpeg-plga Sustained Release Salmon Calcitonin
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
DOI10.1016/j.jcis.2016.05.045
收录类别SCI
语种英语
关键词[WOS]BIODEGRADABLE POLYMERIC MICROSPHERES ; NARROW SIZE DISTRIBUTION ; HUMAN GROWTH-HORMONE ; PLGA MICROSPHERES ; PLA MICROSPHERES ; MEMBRANE EMULSIFICATION ; CONTROLLED-RELEASE ; DELIVERY ; MICROENCAPSULATION ; MICROPARTICLES
WOS研究方向Chemistry
WOS类目Chemistry, Physical
项目资助者National Natural Science Foundation of China(21306208 ; 51173187 ; 21336010)
WOS记录号WOS:000380385500006
引用统计
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/21427
专题生化工程国家重点实验室
作者单位1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Shenyang Agr Univ, Shenyang 110161, Liaoning, Peoples R China
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Wei, Yi,Wang, Yuxia,Zhang, Huixia,et al. A novel strategy for the preparation of porous microspheres and its application in peptide drug loading[J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE,2016,478(SEP):46-53.
APA Wei, Yi,Wang, Yuxia,Zhang, Huixia,Zhou, Weiqing,&Ma, Guanghui.(2016).A novel strategy for the preparation of porous microspheres and its application in peptide drug loading.JOURNAL OF COLLOID AND INTERFACE SCIENCE,478(SEP),46-53.
MLA Wei, Yi,et al."A novel strategy for the preparation of porous microspheres and its application in peptide drug loading".JOURNAL OF COLLOID AND INTERFACE SCIENCE 478.SEP(2016):46-53.
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