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A novel strategy for the preparation of porous microspheres and its application in peptide drug loading
Wei, Yi1; Wang, Yuxia1; Zhang, Huixia2; Zhou, Weiqing1; Ma, Guanghui1
2016-09-15
Source PublicationJOURNAL OF COLLOID AND INTERFACE SCIENCE
ISSN0021-9797
Volume478Issue:SEPPages:46-53
Abstract

A new strategy is developed to prepare porous microspheres with narrow size distribution for peptides controlled release, involving a fabrication of porous microspheres without any porogens followed by a pore closing process. Amphiphilic polymers with different hydrophobic segments (poly(monomethoxy-polyethylene glycol-co-D,L-lactide) (mPEG-PLA), poly(monomethoxypolyethylene co-glycolic acid) (mPEG-PLGA)) are employed as microspheres matrix to prepare porous microspheres based on a double emulsion-premix membrane emulsification technique combined with a solvent evaporation method. Both microspheres possess narrow size distribution and porous surface, which are mainly caused by (a) hydrophilic polyethylene glycol (PEG) segments absorbing water molecules followed by a water evaporation process and (b) local explosion of microspheres due to fast evaporation of dichloromethane (MC). Importantly, mPEG-PLGA microspheres have a honeycomb like structure while mPEG-PLA microspheres have a solid structure internally, illustrating that the different hydrophobic segments could modulate the affinity between solvent and matrix polymer and influence the phase separation rate of microspheres matrix. Long term release patterns are demonstrated with pore-closed microspheres, which are prepared from mPEG-PLGA microspheres loading salmon calcitonin (SCT). These results suggest that it is potential to construct porous microspheres for drug sustained release using permanent geometric templates as new porogens. (C) 2016 Elsevier Inc. All rights reserved.

KeywordPorous Microspheres Narrow Size Distribution Mpeg-plga Sustained Release Salmon Calcitonin
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1016/j.jcis.2016.05.045
Indexed BySCI
Language英语
WOS KeywordBIODEGRADABLE POLYMERIC MICROSPHERES ; NARROW SIZE DISTRIBUTION ; HUMAN GROWTH-HORMONE ; PLGA MICROSPHERES ; PLA MICROSPHERES ; MEMBRANE EMULSIFICATION ; CONTROLLED-RELEASE ; DELIVERY ; MICROENCAPSULATION ; MICROPARTICLES
WOS Research AreaChemistry
WOS SubjectChemistry, Physical
Funding OrganizationNational Natural Science Foundation of China(21306208 ; 51173187 ; 21336010)
WOS IDWOS:000380385500006
Citation statistics
Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/21427
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Shenyang Agr Univ, Shenyang 110161, Liaoning, Peoples R China
Recommended Citation
GB/T 7714
Wei, Yi,Wang, Yuxia,Zhang, Huixia,et al. A novel strategy for the preparation of porous microspheres and its application in peptide drug loading[J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE,2016,478(SEP):46-53.
APA Wei, Yi,Wang, Yuxia,Zhang, Huixia,Zhou, Weiqing,&Ma, Guanghui.(2016).A novel strategy for the preparation of porous microspheres and its application in peptide drug loading.JOURNAL OF COLLOID AND INTERFACE SCIENCE,478(SEP),46-53.
MLA Wei, Yi,et al."A novel strategy for the preparation of porous microspheres and its application in peptide drug loading".JOURNAL OF COLLOID AND INTERFACE SCIENCE 478.SEP(2016):46-53.
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