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Preparation of multicompartment silica-gelatin nanoparticles with self-decomposability as drug containers for cancer therapy in vitro
Wang, Anhe1; Yang, Yang2; Yan, Xuehai1; Ma, Guanghui1; Bai, Shuo1; Li, Junbai2,3
2016
Source PublicationRSC ADVANCES
ISSN2046-2069
Volume6Issue:74Pages:70064-70071
Abstract

We demonstrate multicompartment silica-gelatin nanoparticles (MSGNs), using gelatin doped CaCO3 particles as templates, with self-decomposability in response to body temperature as drug carriers for cancer therapy in vitro. The use of CaCO3 particles provides facile size control of MSGNs in nanoscale without using surfactants. Gelatin involved in the hybrid particles will cover the surface of particles, reducing the toxicity of silica materials caused by Si-OH groups, and moreover plays the role of the cement in the construction to hold the multicompartment structure. Above the gelation temperature, gelatin molecules can escape from particles resulting in the self-decomposition of MSGNs under body conditions. The obtained MSGNs have the potential to be used as an efficient carrier in cancer therapy.

SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1039/c6ra10743e
Indexed BySCI
Language英语
WOS KeywordDELIVERY SYSTEMS ; SIRNA DELIVERY ; RELEASE ; FABRICATION ; CARRIER ; VIVO ; PH ; IMMOBILIZATION ; NANOSPHERES ; POLYCATION
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
Funding OrganizationTalent Fund of the Recruitment Program of Global Youth Experts ; National Nature Science Foundation of China(51303038 ; National Basic Research Program of China(2013CB932800) ; National key foundation for exploring scientific instrument(2013YQ16055108) ; 21273055)
WOS IDWOS:000381512800050
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/21453
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Chem, Key Lab Colloid Interface & Chem Thermodynam, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Wang, Anhe,Yang, Yang,Yan, Xuehai,et al. Preparation of multicompartment silica-gelatin nanoparticles with self-decomposability as drug containers for cancer therapy in vitro[J]. RSC ADVANCES,2016,6(74):70064-70071.
APA Wang, Anhe,Yang, Yang,Yan, Xuehai,Ma, Guanghui,Bai, Shuo,&Li, Junbai.(2016).Preparation of multicompartment silica-gelatin nanoparticles with self-decomposability as drug containers for cancer therapy in vitro.RSC ADVANCES,6(74),70064-70071.
MLA Wang, Anhe,et al."Preparation of multicompartment silica-gelatin nanoparticles with self-decomposability as drug containers for cancer therapy in vitro".RSC ADVANCES 6.74(2016):70064-70071.
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