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Preparation of multicompartment silica-gelatin nanoparticles with self-decomposability as drug containers for cancer therapy in vitro
Wang, Anhe1; Yang, Yang2; Yan, Xuehai1; Ma, Guanghui1; Bai, Shuo1; Li, Junbai2,3
2016
发表期刊RSC ADVANCES
ISSN2046-2069
卷号6期号:74页码:70064-70071
摘要

We demonstrate multicompartment silica-gelatin nanoparticles (MSGNs), using gelatin doped CaCO3 particles as templates, with self-decomposability in response to body temperature as drug carriers for cancer therapy in vitro. The use of CaCO3 particles provides facile size control of MSGNs in nanoscale without using surfactants. Gelatin involved in the hybrid particles will cover the surface of particles, reducing the toxicity of silica materials caused by Si-OH groups, and moreover plays the role of the cement in the construction to hold the multicompartment structure. Above the gelation temperature, gelatin molecules can escape from particles resulting in the self-decomposition of MSGNs under body conditions. The obtained MSGNs have the potential to be used as an efficient carrier in cancer therapy.

文章类型Article
WOS标题词Science & Technology ; Physical Sciences
DOI10.1039/c6ra10743e
收录类别SCI
语种英语
关键词[WOS]DELIVERY SYSTEMS ; SIRNA DELIVERY ; RELEASE ; FABRICATION ; CARRIER ; VIVO ; PH ; IMMOBILIZATION ; NANOSPHERES ; POLYCATION
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
项目资助者Talent Fund of the Recruitment Program of Global Youth Experts ; National Nature Science Foundation of China(51303038 ; National Basic Research Program of China(2013CB932800) ; National key foundation for exploring scientific instrument(2013YQ16055108) ; 21273055)
WOS记录号WOS:000381512800050
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/21453
专题生化工程国家重点实验室
作者单位1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Chem, Key Lab Colloid Interface & Chem Thermodynam, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714
Wang, Anhe,Yang, Yang,Yan, Xuehai,et al. Preparation of multicompartment silica-gelatin nanoparticles with self-decomposability as drug containers for cancer therapy in vitro[J]. RSC ADVANCES,2016,6(74):70064-70071.
APA Wang, Anhe,Yang, Yang,Yan, Xuehai,Ma, Guanghui,Bai, Shuo,&Li, Junbai.(2016).Preparation of multicompartment silica-gelatin nanoparticles with self-decomposability as drug containers for cancer therapy in vitro.RSC ADVANCES,6(74),70064-70071.
MLA Wang, Anhe,et al."Preparation of multicompartment silica-gelatin nanoparticles with self-decomposability as drug containers for cancer therapy in vitro".RSC ADVANCES 6.74(2016):70064-70071.
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