| Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy | |
| Zhang, Ran1,2; Li, Yan1; Hu, Bingbing1; Lu, Zhiguo1,3; Zhang, Jinchao2; Zhang, Xin1 | |
| 2016-08-10 | |
| Source Publication | ADVANCED MATERIALS
 |
| ISSN | 0935-9648 |
| Volume | 28Issue:30Pages:6345-+ |
| Abstract | Nanoparticles that can efficiently control the differentiation of neural stem cells (NSCs) into neurons are developed for Alzheimer's disease (AD) therapy. The treatment with these nanoparticles results in an attenuation of neuronal loss and rescues memory deficiencies in mice. The system can also be used to monitor the transplantation site, as well as the migration of NSCs in real time. Therefore, the system is proposed to open up new avenues for AD treatment. |
| Subtype | Article |
| WOS Headings | Science & Technology ; Physical Sciences ; Technology |
| DOI | 10.1002/adma.201600554 |
| Indexed By | SCI |
| Language | 英语 |
| WOS Keyword | SIRNA DELIVERY ; IMPROVE COGNITION ; TRANSGENIC MODELS ; SMALL MOLECULES ; DRUG-DELIVERY ; BRAIN ; TRANSPLANTATION ; PROLIFERATION ; DERIVATIVES ; EFFICIENCY |
| WOS Research Area | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS Subject | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| Funding Organization | National Natural Science Foundation of China(31522023 ; National High Technology Research and Development Program(2014AA020708) ; Chinese Academy of Sciences(YZ201313 ; Beijing National Science Foundation(Z141100000214010) ; Key Basic Research Special Foundation of Science Technology Ministry of Hebei Province(14961302D) ; Hebei Province "Hundred Talents Program"(BR2-202) ; Hebei Province "Three Three Three Talents Program"(A201401002) ; 51373177 ; XDA09030301-3) ; 31470961) |
| WOS ID | WOS:000382480100006 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/21460 |
| Collection | 生化工程国家重点实验室 |
| Affiliation | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Hebei Univ, Key Lab Med Chem & Mol Diag, Minist Educ, Coll Chem & Environm Sci,Chem Biol Key Lab Hebei, Baoding 071002, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Zhang, Ran,Li, Yan,Hu, Bingbing,et al. Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy[J]. ADVANCED MATERIALS,2016,28(30):6345-+. |
| APA | Zhang, Ran,Li, Yan,Hu, Bingbing,Lu, Zhiguo,Zhang, Jinchao,&Zhang, Xin.(2016).Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy.ADVANCED MATERIALS,28(30),6345-+. |
| MLA | Zhang, Ran,et al."Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy".ADVANCED MATERIALS 28.30(2016):6345-+. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Zhang_et_al-2016-Adv（2311KB） | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | Application Full Text | |
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