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Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy
Zhang, Ran1,2; Li, Yan1; Hu, Bingbing1; Lu, Zhiguo1,3; Zhang, Jinchao2; Zhang, Xin1
2016-08-10
Source PublicationADVANCED MATERIALS
ISSN0935-9648
Volume28Issue:30Pages:6345-+
Abstract

Nanoparticles that can efficiently control the differentiation of neural stem cells (NSCs) into neurons are developed for Alzheimer's disease (AD) therapy. The treatment with these nanoparticles results in an attenuation of neuronal loss and rescues memory deficiencies in mice. The system can also be used to monitor the transplantation site, as well as the migration of NSCs in real time. Therefore, the system is proposed to open up new avenues for AD treatment.

SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
DOI10.1002/adma.201600554
Indexed BySCI
Language英语
WOS KeywordSIRNA DELIVERY ; IMPROVE COGNITION ; TRANSGENIC MODELS ; SMALL MOLECULES ; DRUG-DELIVERY ; BRAIN ; TRANSPLANTATION ; PROLIFERATION ; DERIVATIVES ; EFFICIENCY
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
Funding OrganizationNational Natural Science Foundation of China(31522023 ; National High Technology Research and Development Program(2014AA020708) ; Chinese Academy of Sciences(YZ201313 ; Beijing National Science Foundation(Z141100000214010) ; Key Basic Research Special Foundation of Science Technology Ministry of Hebei Province(14961302D) ; Hebei Province "Hundred Talents Program"(BR2-202) ; Hebei Province "Three Three Three Talents Program"(A201401002) ; 51373177 ; XDA09030301-3) ; 31470961)
WOS IDWOS:000382480100006
Citation statistics
Cited Times:27[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/21460
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Hebei Univ, Key Lab Med Chem & Mol Diag, Minist Educ, Coll Chem & Environm Sci,Chem Biol Key Lab Hebei, Baoding 071002, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Ran,Li, Yan,Hu, Bingbing,et al. Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy[J]. ADVANCED MATERIALS,2016,28(30):6345-+.
APA Zhang, Ran,Li, Yan,Hu, Bingbing,Lu, Zhiguo,Zhang, Jinchao,&Zhang, Xin.(2016).Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy.ADVANCED MATERIALS,28(30),6345-+.
MLA Zhang, Ran,et al."Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy".ADVANCED MATERIALS 28.30(2016):6345-+.
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