Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy

doi:10.1002/adma.201600554

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	Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy
	Zhang, Ran 1,2; Li, Yan 1; Hu, Bingbing 1; Lu, Zhiguo 1,3; Zhang, Jinchao 2; Zhang, Xin 1
	2016-08-10
Source Publication	ADVANCED MATERIALS
ISSN	0935-9648
Volume	28 Issue:30 Pages:6345-+
Abstract	Nanoparticles that can efficiently control the differentiation of neural stem cells (NSCs) into neurons are developed for Alzheimer's disease (AD) therapy. The treatment with these nanoparticles results in an attenuation of neuronal loss and rescues memory deficiencies in mice. The system can also be used to monitor the transplantation site, as well as the migration of NSCs in real time. Therefore, the system is proposed to open up new avenues for AD treatment.
Subtype	Article
WOS Headings	Science & Technology ; Physical Sciences ; Technology
DOI	10.1002/adma.201600554
Indexed By	SCI
Language	英语
WOS Keyword	SIRNA DELIVERY ; IMPROVE COGNITION ; TRANSGENIC MODELS ; SMALL MOLECULES ; DRUG-DELIVERY ; BRAIN ; TRANSPLANTATION ; PROLIFERATION ; DERIVATIVES ; EFFICIENCY
WOS Research Area	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS Subject	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
Funding Organization	National Natural Science Foundation of China(31522023 ; National High Technology Research and Development Program(2014AA020708) ; Chinese Academy of Sciences(YZ201313 ; Beijing National Science Foundation(Z141100000214010) ; Key Basic Research Special Foundation of Science Technology Ministry of Hebei Province(14961302D) ; Hebei Province "Hundred Talents Program"(BR2-202) ; Hebei Province "Three Three Three Talents Program"(A201401002) ; 51373177 ; XDA09030301-3) ; 31470961)
WOS ID	WOS:000382480100006
Citation statistics
Document Type	期刊论文
Identifier	http://ir.ipe.ac.cn/handle/122111/21460
Collection	生化工程国家重点实验室
Affiliation	1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Hebei Univ, Key Lab Med Chem & Mol Diag, Minist Educ, Coll Chem & Environm Sci,Chem Biol Key Lab Hebei, Baoding 071002, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100190, Peoples R China
Recommended Citation GB/T 7714	Zhang, Ran,Li, Yan,Hu, Bingbing,et al. Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy[J]. ADVANCED MATERIALS,2016,28(30):6345-+.
APA	Zhang, Ran,Li, Yan,Hu, Bingbing,Lu, Zhiguo,Zhang, Jinchao,&Zhang, Xin.(2016).Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy.ADVANCED MATERIALS,28(30),6345-+.
MLA	Zhang, Ran,et al."Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy".ADVANCED MATERIALS 28.30(2016):6345-+.

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