| Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy | |
| Zhang, Ran1,2; Li, Yan1; Hu, Bingbing1; Lu, Zhiguo1,3; Zhang, Jinchao2; Zhang, Xin1 | |
| 2016-08-10 | |
| 发表期刊 | ADVANCED MATERIALS
 |
| ISSN | 0935-9648 |
| 卷号 | 28期号:30页码:6345-+ |
| 摘要 | Nanoparticles that can efficiently control the differentiation of neural stem cells (NSCs) into neurons are developed for Alzheimer's disease (AD) therapy. The treatment with these nanoparticles results in an attenuation of neuronal loss and rescues memory deficiencies in mice. The system can also be used to monitor the transplantation site, as well as the migration of NSCs in real time. Therefore, the system is proposed to open up new avenues for AD treatment. |
| 文章类型 | Article |
| WOS标题词 | Science & Technology ; Physical Sciences ; Technology |
| DOI | 10.1002/adma.201600554 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | SIRNA DELIVERY ; IMPROVE COGNITION ; TRANSGENIC MODELS ; SMALL MOLECULES ; DRUG-DELIVERY ; BRAIN ; TRANSPLANTATION ; PROLIFERATION ; DERIVATIVES ; EFFICIENCY |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 项目资助者 | National Natural Science Foundation of China(31522023 ; National High Technology Research and Development Program(2014AA020708) ; Chinese Academy of Sciences(YZ201313 ; Beijing National Science Foundation(Z141100000214010) ; Key Basic Research Special Foundation of Science Technology Ministry of Hebei Province(14961302D) ; Hebei Province "Hundred Talents Program"(BR2-202) ; Hebei Province "Three Three Three Talents Program"(A201401002) ; 51373177 ; XDA09030301-3) ; 31470961) |
| WOS记录号 | WOS:000382480100006 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ipe.ac.cn/handle/122111/21460 |
| 专题 | 生化工程国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Hebei Univ, Key Lab Med Chem & Mol Diag, Minist Educ, Coll Chem & Environm Sci,Chem Biol Key Lab Hebei, Baoding 071002, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Ran,Li, Yan,Hu, Bingbing,et al. Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy[J]. ADVANCED MATERIALS,2016,28(30):6345-+. |
| APA | Zhang, Ran,Li, Yan,Hu, Bingbing,Lu, Zhiguo,Zhang, Jinchao,&Zhang, Xin.(2016).Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy.ADVANCED MATERIALS,28(30),6345-+. |
| MLA | Zhang, Ran,et al."Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy".ADVANCED MATERIALS 28.30(2016):6345-+. |
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| Zhang_et_al-2016-Adv（2311KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |
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