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Biomimetic Immuno-Magnetosomes for High-Performance Enrichment of Circulating Tumor Cells
Xiong, Ke1; Wei, Wei2; Jin, Yongjie1; Wang, Shumin1,2; Zhao, Dongxu1; Wang, Shuang; Gao, Xiaoyong2; Qiao, Chenmeng2; Yue, Hua2; Ma, Guanghui2; Xie, Hai-Yan1
2016-09-28
Source PublicationADVANCED MATERIALS
ISSN0935-9648
Volume28Issue:36Pages:7929-7935
Abstract

A novel biomimetic immuno-magnetosome (IMS) is developed by coating a leukocyte membrane (decorated with anti-epithelial cell-adhesion molecule antibody) on a magnetic nanocluster. In addition to the good stability and magnetic controllability, the IMS also exhibits satisfactory binding avidity to circulating tumor cells but stealth property to leukocytes. As a result, rare tumor cells can be effectively enriched with undetectable leukocyte background.

SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
DOI10.1002/adma.201601643
Indexed BySCI
Language英语
WOS KeywordCANCER-CELLS ; CAPTURE ; BLOOD ; NANOPARTICLES ; PURIFICATION ; CHALLENGES ; DELIVERY ; BINDING ; DNA
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
Funding Organization863 Program(2013AA032204) ; National Natural Science Foundation of China(21422502 ; Beijing Nova Program(Z141102001814066) ; Beijing Talents Fund(2015000021223ZK20) ; 21372028)
WOS IDWOS:000384677700008
Citation statistics
Cited Times:35[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/21478
Collection生化工程国家重点实验室
Affiliation1.Beijing Inst Technol, Sch Life Sci, Beijing 100081, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Xiong, Ke,Wei, Wei,Jin, Yongjie,et al. Biomimetic Immuno-Magnetosomes for High-Performance Enrichment of Circulating Tumor Cells[J]. ADVANCED MATERIALS,2016,28(36):7929-7935.
APA Xiong, Ke.,Wei, Wei.,Jin, Yongjie.,Wang, Shumin.,Zhao, Dongxu.,...&Xie, Hai-Yan.(2016).Biomimetic Immuno-Magnetosomes for High-Performance Enrichment of Circulating Tumor Cells.ADVANCED MATERIALS,28(36),7929-7935.
MLA Xiong, Ke,et al."Biomimetic Immuno-Magnetosomes for High-Performance Enrichment of Circulating Tumor Cells".ADVANCED MATERIALS 28.36(2016):7929-7935.
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