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A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses
Zha, Jun1,2; Liu, Xiang-meng1,3; Zhu, Jie1; Liu, Shu-ying1,4; Lu, Shuai1; Xu, Peng-xin4; Yu, Xiao-lin1; Liu, Rui-tian1
2016-11-08
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume6Issue:NOVPages:36631
Abstract

Overproduction or poor clearance of amyloids lead to amyloid aggregation and even amyloidosis development. Different amyloids may interact synergistically to promote their aggregation and accelerate pathology in amyloidoses. Amyloid oligomers assembled from different amyloids share common structures and epitopes, and are considered the most toxic species in the pathologic processes of amyloidoses, which suggests that an agent targeting the common epitope of toxic oligomers could provide benefit to several amyloidoses. In this study, we firstly showed that an oligomer-specific single-chain variable fragment antibody, W20 simultaneously improved motor and cognitive function in Parkinson's disease and Huntington's disease mouse models, and attenuated a number of neuropathological features by reducing alpha-synuclein and mutant huntingtin protein aggregate load and preventing synaptic degeneration. Neuroinflammation and oxidative stress in vivo were also markedly inhibited. The proposed strategy targeting the common epitopes of amyloid oligomers presents promising potential for treating Parkinson's disease, Huntington's disease, Alzheimer's disease, and other amyloidoses.

SubtypeArticle
WOS HeadingsScience & Technology
DOI10.1038/srep36631
Indexed BySCI
Language英语
WOS KeywordHUMAN ALPHA-SYNUCLEIN ; DISEASE TRANSGENIC MICE ; RESCUES MEMORY DEFICITS ; HUNTINGTONS-DISEASE ; ALZHEIMERS-DISEASE ; MOUSE MODEL ; MUTANT HUNTINGTIN ; OXIDATIVE STRESS ; A-BETA ; NEURODEGENERATIVE DISEASES
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
Funding OrganizationNational Natural Science Foundation of China(81371208 ; National Science and Technology Major Projects of New Drugs(2014ZX09102045-005 ; 81402837) ; 2014ZX09102041-007)
WOS IDWOS:000387323000001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/21654
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing, Peoples R China
2.China Pharmaceut Univ, Sch Pharm, Nanjing, Jiangsu, Peoples R China
3.Qilu Univ Technol, Sch Bioengn, Jinan, Peoples R China
4.Ningxia Univ, Sch Life Sci, Yinchuan, Peoples R China
Recommended Citation
GB/T 7714
Zha, Jun,Liu, Xiang-meng,Zhu, Jie,et al. A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses[J]. SCIENTIFIC REPORTS,2016,6(NOV):36631.
APA Zha, Jun.,Liu, Xiang-meng.,Zhu, Jie.,Liu, Shu-ying.,Lu, Shuai.,...&Liu, Rui-tian.(2016).A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses.SCIENTIFIC REPORTS,6(NOV),36631.
MLA Zha, Jun,et al."A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses".SCIENTIFIC REPORTS 6.NOV(2016):36631.
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