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A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses
Zha, Jun1,2; Liu, Xiang-meng1,3; Zhu, Jie1; Liu, Shu-ying1,4; Lu, Shuai1; Xu, Peng-xin4; Yu, Xiao-lin1; Liu, Rui-tian1
2016-11-08
发表期刊SCIENTIFIC REPORTS
ISSN2045-2322
卷号6期号:NOV页码:36631
摘要

Overproduction or poor clearance of amyloids lead to amyloid aggregation and even amyloidosis development. Different amyloids may interact synergistically to promote their aggregation and accelerate pathology in amyloidoses. Amyloid oligomers assembled from different amyloids share common structures and epitopes, and are considered the most toxic species in the pathologic processes of amyloidoses, which suggests that an agent targeting the common epitope of toxic oligomers could provide benefit to several amyloidoses. In this study, we firstly showed that an oligomer-specific single-chain variable fragment antibody, W20 simultaneously improved motor and cognitive function in Parkinson's disease and Huntington's disease mouse models, and attenuated a number of neuropathological features by reducing alpha-synuclein and mutant huntingtin protein aggregate load and preventing synaptic degeneration. Neuroinflammation and oxidative stress in vivo were also markedly inhibited. The proposed strategy targeting the common epitopes of amyloid oligomers presents promising potential for treating Parkinson's disease, Huntington's disease, Alzheimer's disease, and other amyloidoses.

文章类型Article
WOS标题词Science & Technology
DOI10.1038/srep36631
收录类别SCI
语种英语
关键词[WOS]HUMAN ALPHA-SYNUCLEIN ; DISEASE TRANSGENIC MICE ; RESCUES MEMORY DEFICITS ; HUNTINGTONS-DISEASE ; ALZHEIMERS-DISEASE ; MOUSE MODEL ; MUTANT HUNTINGTIN ; OXIDATIVE STRESS ; A-BETA ; NEURODEGENERATIVE DISEASES
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
项目资助者National Natural Science Foundation of China(81371208 ; National Science and Technology Major Projects of New Drugs(2014ZX09102045-005 ; 81402837) ; 2014ZX09102041-007)
WOS记录号WOS:000387323000001
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/21654
专题生化工程国家重点实验室
作者单位1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing, Peoples R China
2.China Pharmaceut Univ, Sch Pharm, Nanjing, Jiangsu, Peoples R China
3.Qilu Univ Technol, Sch Bioengn, Jinan, Peoples R China
4.Ningxia Univ, Sch Life Sci, Yinchuan, Peoples R China
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GB/T 7714
Zha, Jun,Liu, Xiang-meng,Zhu, Jie,et al. A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses[J]. SCIENTIFIC REPORTS,2016,6(NOV):36631.
APA Zha, Jun.,Liu, Xiang-meng.,Zhu, Jie.,Liu, Shu-ying.,Lu, Shuai.,...&Liu, Rui-tian.(2016).A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses.SCIENTIFIC REPORTS,6(NOV),36631.
MLA Zha, Jun,et al."A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidoses".SCIENTIFIC REPORTS 6.NOV(2016):36631.
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