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Injectable Self-Assembled Dipeptide-Based Nanocarriers for Tumor Delivery and Effective In Vivo Photodynamic Therapy
Ma, Kai1,2; Xing, Ruirui1,2; Jiao, Tifeng1,2; Shen, Guizhi3; Chen, Chengjun3; Li, Junbai4; Yan, Xuehai3
2016-11-16
发表期刊ACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
卷号8期号:45页码:30759-30767
摘要

Self-assembling peptide-based materials are playing an important role in fabricating drug delivery carriers; however, they are often limited by several challenges, such as precise structure modulation, desirable nanoscale size, and sufficient circulation lifetime in the body. To address this issue, herein one type of injectable dipeptide-based nanocarriers with well modulated size and structure has been developed by adjusting glutaraldehyde (GA)-assisted cationic dipeptide (CDP) assembly. After loading a model photosensitive drug (Ce6) and further decorating CDP nanoparticles (NPs) with heparin polymers (Hep), the desired dipeptide-based NPs are achieved with an average diameter of 100 rim and surface charge of -25 mV, which are favorable for the enhanced permeability and retention effects. Significantly, the dipeptide-based NPs with Ce6 loading have a longer circulation lifetime against opsonization than free Ce6 solution, and subsequently, they achieve the best anticancer efficiency in vivo. They do not cause body weight loss or induce bad immune activation in organs, implying good biosafety of the designed carriers. Taken together, dipeptide-based delivery carriers through GA-assisted assembly may provide a new alternative for developing precisely controlled nanostructures toward effective antitumor therapy.

关键词Dipeptide Self-assembly Nanoparticle Drug Delivery Photodynamic Therapy
文章类型Article
WOS标题词Science & Technology ; Technology
DOI10.1021/acsami.6b10754
收录类别SCI
语种英语
关键词[WOS]DRUG-DELIVERY ; TERNARY COMPLEXES ; ANTICANCER DRUG ; PEPTIDE ; CANCER ; ACID ; NANOPARTICLES ; RELEASE ; PHOTOSENSITIZER ; NANOSTRUCTURES
WOS研究方向Science & Technology - Other Topics ; Materials Science
WOS类目Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
项目资助者National Natural Science Foundation of China (NSFC)(21522307 ; Chinese Academy of Sciences(QYZDB-SSW-JSC034) ; Scientific & Technological Research and Development Program of Qinhuangdao City(201502A006) ; Science Foundation for the Excellent Youth Scholars from Universities and Colleges of Hebei Province(YQ2013026) ; Postgraduate's Innovation Fund Project of Hebei Province(2016SJBS009) ; Support Program for the Top Young Talents of Hebei Province ; Open Funding Project of the State Key Laboratory of Biochemical Engineering(2013K-02) ; China Postdoctoral Science Foundation(2015M580214) ; 21473208 ; 8140287 ; 21473153 ; 21603233)
WOS记录号WOS:000388429600013
引用统计
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/21682
专题生化工程国家重点实验室
作者单位1.Yanshan Univ, State Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Peoples R China
2.Yanshan Univ, Hebei Key Lab Appl Chem, Sch Environm & Chem Engn, Qinhuangdao 066004, Peoples R China
3.Chinese Acad Sci, IPE, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Key Lab Colloid & Interface Sci, Beijing 100190, Peoples R China
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GB/T 7714
Ma, Kai,Xing, Ruirui,Jiao, Tifeng,et al. Injectable Self-Assembled Dipeptide-Based Nanocarriers for Tumor Delivery and Effective In Vivo Photodynamic Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(45):30759-30767.
APA Ma, Kai.,Xing, Ruirui.,Jiao, Tifeng.,Shen, Guizhi.,Chen, Chengjun.,...&Yan, Xuehai.(2016).Injectable Self-Assembled Dipeptide-Based Nanocarriers for Tumor Delivery and Effective In Vivo Photodynamic Therapy.ACS APPLIED MATERIALS & INTERFACES,8(45),30759-30767.
MLA Ma, Kai,et al."Injectable Self-Assembled Dipeptide-Based Nanocarriers for Tumor Delivery and Effective In Vivo Photodynamic Therapy".ACS APPLIED MATERIALS & INTERFACES 8.45(2016):30759-30767.
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