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Synergistic in vivo photodynamic and photothermal antitumor therapy based on collagen-gold hybrid hydrogels with inclusion of photosensitive drugs
Sun, Jiajia1; Guo, Ying1; Xing, Ruirui2,3; Jiao, Tifeng3; Zou, Qianli2; Yan, Xuehai2
2017-02-05
发表期刊COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
ISSN0927-7757
卷号514页码:155-160
摘要Phototherapies, including photodynamic therapy (PDT) and photothermal therapy (PTT), have shown great potential in non-invasive tumor treatments. To achieve targeted and effective antitumor therapy, it is highly desirable to combine the advantages of PDT and PTT in a delivery platform. Herein, we report a strategy to achieve synergistic PDT and PTT based on collagen-gold hybrid hydrogels, in which gold nanoparticles are incorporated as photothermal agents for PTT and photosensitive drugs are entrapped as photodynamic agents for PDT. In vivo antitumor results reveal that synergistic PDT and PTT exhibit the best antitumor effect with a tumor elimination rate up to 80% while PDT and PTT alone show less effective tumor inhibition. This synergistic therapy by the designed hydrogels does not cause body weight loss as compared to the control group without any treatment. Taken together, such a therapeutic strategy based on collagen-gold hybrid hydrogels with inclusion of photosensitive drugs may provide new alternatives for developing a type of delivery nanosystems toward synergistic antitumor therapy. (C) 2016 Published by Elsevier B.V.
关键词Collagen Hydrogel Self-assembly Photodynamic Therapy Photothermal Therapy Anticancer
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
DOI10.1016/j.colsurfa.2016.11.062
收录类别SCI
语种英语
关键词[WOS]PROTEIN ; CANCER ; GROWTH ; VITRO
WOS研究方向Chemistry
WOS类目Chemistry, Physical
项目资助者National Natural Science Foundation of China(21522307 ; Beijing Natural Science Foundation(7154220) ; Chinese Academy of Sciences (CAS)(QYZDB-SSW-JSC034) ; Youth Innovation Promotion Association CAS ; Talent Fund of the Recruitment Program of Global Youth Experts ; 21473208 ; 91434103 ; 51403214 ; 8140287)
WOS记录号WOS:000390366400018
引用统计
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/21860
专题生化工程国家重点实验室
作者单位1.Harbin Univ Sci & Technol, Sch Chem & Environm Engn, Harbin 150080, Peoples R China
2.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
3.Yanshan Univ, Sch Environm & Chem Engn, Hebei Key Lab Appl Chem, Qinhuangdao 066004, Peoples R China
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Sun, Jiajia,Guo, Ying,Xing, Ruirui,et al. Synergistic in vivo photodynamic and photothermal antitumor therapy based on collagen-gold hybrid hydrogels with inclusion of photosensitive drugs[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2017,514:155-160.
APA Sun, Jiajia,Guo, Ying,Xing, Ruirui,Jiao, Tifeng,Zou, Qianli,&Yan, Xuehai.(2017).Synergistic in vivo photodynamic and photothermal antitumor therapy based on collagen-gold hybrid hydrogels with inclusion of photosensitive drugs.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,514,155-160.
MLA Sun, Jiajia,et al."Synergistic in vivo photodynamic and photothermal antitumor therapy based on collagen-gold hybrid hydrogels with inclusion of photosensitive drugs".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 514(2017):155-160.
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