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Synergistic in vivo photodynamic and photothermal antitumor therapy based on collagen-gold hybrid hydrogels with inclusion of photosensitive drugs
Sun, Jiajia1; Guo, Ying1; Xing, Ruirui2,3; Jiao, Tifeng3; Zou, Qianli2; Yan, Xuehai2
2017-02-05
Source PublicationCOLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
ISSN0927-7757
Volume514Pages:155-160
Abstract

Phototherapies, including photodynamic therapy (PDT) and photothermal therapy (PTT), have shown great potential in non-invasive tumor treatments. To achieve targeted and effective antitumor therapy, it is highly desirable to combine the advantages of PDT and PTT in a delivery platform. Herein, we report a strategy to achieve synergistic PDT and PTT based on collagen-gold hybrid hydrogels, in which gold nanoparticles are incorporated as photothermal agents for PTT and photosensitive drugs are entrapped as photodynamic agents for PDT. In vivo antitumor results reveal that synergistic PDT and PTT exhibit the best antitumor effect with a tumor elimination rate up to 80% while PDT and PTT alone show less effective tumor inhibition. This synergistic therapy by the designed hydrogels does not cause body weight loss as compared to the control group without any treatment. Taken together, such a therapeutic strategy based on collagen-gold hybrid hydrogels with inclusion of photosensitive drugs may provide new alternatives for developing a type of delivery nanosystems toward synergistic antitumor therapy. (C) 2016 Published by Elsevier B.V.

KeywordCollagen Hydrogel Self-assembly Photodynamic Therapy Photothermal Therapy Anticancer
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1016/j.colsurfa.2016.11.062
Indexed BySCI
Language英语
WOS KeywordProtein ; Cancer ; Growth ; Vitro
WOS Research AreaChemistry
WOS SubjectChemistry, Physical
Funding OrganizationNational Natural Science Foundation of China(21522307 ; Beijing Natural Science Foundation(7154220) ; Chinese Academy of Sciences (CAS)(QYZDB-SSW-JSC034) ; Youth Innovation Promotion Association CAS ; Talent Fund of the Recruitment Program of Global Youth Experts ; 21473208 ; 91434103 ; 51403214 ; 8140287)
WOS IDWOS:000390366400018
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/21860
Collection生化工程国家重点实验室
Affiliation1.Harbin Univ Sci & Technol, Sch Chem & Environm Engn, Harbin 150080, Peoples R China
2.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
3.Yanshan Univ, Sch Environm & Chem Engn, Hebei Key Lab Appl Chem, Qinhuangdao 066004, Peoples R China
Recommended Citation
GB/T 7714
Sun, Jiajia,Guo, Ying,Xing, Ruirui,et al. Synergistic in vivo photodynamic and photothermal antitumor therapy based on collagen-gold hybrid hydrogels with inclusion of photosensitive drugs[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2017,514:155-160.
APA Sun, Jiajia,Guo, Ying,Xing, Ruirui,Jiao, Tifeng,Zou, Qianli,&Yan, Xuehai.(2017).Synergistic in vivo photodynamic and photothermal antitumor therapy based on collagen-gold hybrid hydrogels with inclusion of photosensitive drugs.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,514,155-160.
MLA Sun, Jiajia,et al."Synergistic in vivo photodynamic and photothermal antitumor therapy based on collagen-gold hybrid hydrogels with inclusion of photosensitive drugs".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 514(2017):155-160.
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