CAS OpenIR  > 湿法冶金清洁生产技术国家工程实验室
Mesoporous Silica Coated Polydopamine Functionalized Reduced Graphene Oxide for Synergistic Targeted Chemo-Photothermal Therapy
Shao, Leihou1,3; Zhang, Ruirui2; Lu, Jianqing1,3; Zhao, Caiyan1,3; Deng, Xiongwei1,3; Wu, Yan1,3
2017-01-18
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume9Issue:2Pages:1226-1236
Abstract

The integration of different therapies into a single nanoplatform has shown great promise for synergistic tumor treatment. Herein, mesoporous silica (MS) coated polydopamine functionalized reduced graphene oxide (pRGO) further modified with hyaluronic acid (HA) (pRGO@MS-HA) has been utilized as a versatile nanoplatform for synergistic targeted chemo-photothermal therapy against cancer. A facile and green chemical method is adopted for the simultaneous reduction and noncovalent functionalization of graphene oxide (GO) by using mussel inspired dopamine (DA) to enhance biocompatibility and the photothermal effect. Then, it was coated with mesoporous silica (MS) (pRGO@MS) to enhance doxorubicin (DOX) loading and be further modified with the targeting moieties hyaluronic acid (HA). The pH-dependent and near-infrared (NIR) laser irradiation-triggered DOX release from pRGO@MS(DOX)-HA is observed, which could enhance the chemo-photothermal therapy effect. In vitro experimental results confirm that pRGO@MS(DOX)-HA exhibits good dispersibility, excellent photothermal property, remarkable tumor cell killing efficiency, and specificity to target tumor cells. In vivo antitumor experiments further demonstrated that pRGO@MS(DOX)-HA could exhibit an excellent synergistic antitumor efficacy, which is much more distinct than any monotherapy. This work presents a novel nanoplatform which could load chemotherapy drugs with high efficiency and be used as light-mediated photothermal cancer therapy agent.

KeywordPolydopamine Mesoporous Silica Reduced Graphene Oxide Drug Delivery Chemo-photothermal Therapy
SubtypeArticle
WOS HeadingsScience & Technology ; Technology
DOI10.1021/acsami.6b11209
Indexed BySCI
Language英语
WOS KeywordOvercome Drug-resistance ; In-vivo ; Cancer-therapy ; Combination Therapy ; Surface-chemistry ; Nano-graphene ; Nanoparticles ; Delivery ; Nanomaterials ; Doxorubicin
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China(81272453 ; Chinese Academy of Sciences(XDA09030301) ; 81472850)
WOS IDWOS:000392458300009
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/21898
Collection湿法冶金清洁生产技术国家工程实验室
Affiliation1.Chinese Acad Sci, Natl Ctr Nanosci & Technol, Ctr Excellence Nanosci, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, Beijing Key Lab Ion Liquids Clean Proc, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Shao, Leihou,Zhang, Ruirui,Lu, Jianqing,et al. Mesoporous Silica Coated Polydopamine Functionalized Reduced Graphene Oxide for Synergistic Targeted Chemo-Photothermal Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(2):1226-1236.
APA Shao, Leihou,Zhang, Ruirui,Lu, Jianqing,Zhao, Caiyan,Deng, Xiongwei,&Wu, Yan.(2017).Mesoporous Silica Coated Polydopamine Functionalized Reduced Graphene Oxide for Synergistic Targeted Chemo-Photothermal Therapy.ACS APPLIED MATERIALS & INTERFACES,9(2),1226-1236.
MLA Shao, Leihou,et al."Mesoporous Silica Coated Polydopamine Functionalized Reduced Graphene Oxide for Synergistic Targeted Chemo-Photothermal Therapy".ACS APPLIED MATERIALS & INTERFACES 9.2(2017):1226-1236.
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