Mesoporous Silica Coated Polydopamine Functionalized Reduced Graphene Oxide for Synergistic Targeted Chemo-Photothermal Therapy
Shao, Leihou1,3; Zhang, Ruirui2; Lu, Jianqing1,3; Zhao, Caiyan1,3; Deng, Xiongwei1,3; Wu, Yan1,3
2017-01-18
发表期刊ACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
卷号9期号:2页码:1226-1236
摘要The integration of different therapies into a single nanoplatform has shown great promise for synergistic tumor treatment. Herein, mesoporous silica (MS) coated polydopamine functionalized reduced graphene oxide (pRGO) further modified with hyaluronic acid (HA) (pRGO@MS-HA) has been utilized as a versatile nanoplatform for synergistic targeted chemo-photothermal therapy against cancer. A facile and green chemical method is adopted for the simultaneous reduction and noncovalent functionalization of graphene oxide (GO) by using mussel inspired dopamine (DA) to enhance biocompatibility and the photothermal effect. Then, it was coated with mesoporous silica (MS) (pRGO@MS) to enhance doxorubicin (DOX) loading and be further modified with the targeting moieties hyaluronic acid (HA). The pH-dependent and near-infrared (NIR) laser irradiation-triggered DOX release from pRGO@MS(DOX)-HA is observed, which could enhance the chemo-photothermal therapy effect. In vitro experimental results confirm that pRGO@MS(DOX)-HA exhibits good dispersibility, excellent photothermal property, remarkable tumor cell killing efficiency, and specificity to target tumor cells. In vivo antitumor experiments further demonstrated that pRGO@MS(DOX)-HA could exhibit an excellent synergistic antitumor efficacy, which is much more distinct than any monotherapy. This work presents a novel nanoplatform which could load chemotherapy drugs with high efficiency and be used as light-mediated photothermal cancer therapy agent.
关键词Polydopamine Mesoporous Silica Reduced Graphene Oxide Drug Delivery Chemo-photothermal Therapy
文章类型Article
WOS标题词Science & Technology ; Technology
DOI10.1021/acsami.6b11209
收录类别SCI
语种英语
关键词[WOS]OVERCOME DRUG-RESISTANCE ; IN-VIVO ; CANCER-THERAPY ; COMBINATION THERAPY ; SURFACE-CHEMISTRY ; NANO-GRAPHENE ; NANOPARTICLES ; DELIVERY ; NANOMATERIALS ; DOXORUBICIN
WOS研究方向Science & Technology - Other Topics ; Materials Science
WOS类目Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
项目资助者National Natural Science Foundation of China(81272453 ; Chinese Academy of Sciences(XDA09030301) ; 81472850)
WOS记录号WOS:000392458300009
引用统计
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/21898
专题湿法冶金清洁生产技术国家工程实验室
作者单位1.Chinese Acad Sci, Natl Ctr Nanosci & Technol, Ctr Excellence Nanosci, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, Beijing Key Lab Ion Liquids Clean Proc, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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Shao, Leihou,Zhang, Ruirui,Lu, Jianqing,et al. Mesoporous Silica Coated Polydopamine Functionalized Reduced Graphene Oxide for Synergistic Targeted Chemo-Photothermal Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(2):1226-1236.
APA Shao, Leihou,Zhang, Ruirui,Lu, Jianqing,Zhao, Caiyan,Deng, Xiongwei,&Wu, Yan.(2017).Mesoporous Silica Coated Polydopamine Functionalized Reduced Graphene Oxide for Synergistic Targeted Chemo-Photothermal Therapy.ACS APPLIED MATERIALS & INTERFACES,9(2),1226-1236.
MLA Shao, Leihou,et al."Mesoporous Silica Coated Polydopamine Functionalized Reduced Graphene Oxide for Synergistic Targeted Chemo-Photothermal Therapy".ACS APPLIED MATERIALS & INTERFACES 9.2(2017):1226-1236.
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