Polymer-decorated anisotropic silica nanotubes with combined shape and surface properties for guest delivery
Li, Guo Liang1,3; Hu, Jinglei2,6; Wang, Hongqiang4,5; Pilz-Allen, Christine3; Wang, Junpeng1; Qi, Tao1; Moehwald, Helmuth3; Shchukin, Dmitry G.4
2017-01-27
发表期刊POLYMER
ISSN0032-3861
卷号109页码:332-338
摘要We report on amphiphilic diblock copolymer-decorated anisotropic silica nanotubes with well-defined dual functions of shape and surface properties in one nanocontainer. Amphiphilic poly(lactic acid)block-poly(ethylene glycol) (PLA-b-PEG) diblock copolymers are covalently grafted to the surface of mesoporous silica nanotubes via silane chemistry and esterification. The released percentage of probe molecules from the resultant silica-g-(PLA-b-PEG) hybrid nanocontainer is around 40% over a release time of 48 h, in contrast to 90% from bare silica nanotubes prior to surface modification. The diblock copolymer-decorated anisotropic nanocontainers with large aspect ratio lead to enhanced viability of NIH 3T3 fibroblast cells. A theoretical model based on the free energy cost for cell membranes to encapsulate nanocontainers is utilized to understand the cytotoxicity. This work demonstrates that the release dynamics of the active molecules and the interaction of hybrid nanocontainers with cell membranes can be regulated by the synergistic effect of nanocontainer shape and surface properties. (C) 2016 Elsevier Ltd. All rights reserved.
关键词Anisotropic Nanocontainer Silica/polymer Hybrids Controlled Release
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
DOI10.1016/j.polymer.2016.12.048
收录类别SCI
语种英语
关键词[WOS]DRUG-DELIVERY ; BLOCK-COPOLYMERS ; CLICK-CHEMISTRY ; NANOPARTICLES ; OXIDE ; THERAPY ; CORE ; NANOCONTAINERS ; NANOSTRUCTURES ; NANOREACTORS
WOS研究方向Polymer Science
WOS类目Polymer Science
项目资助者One Hundred Talent Program of Chinese Academy of Sciences ; Alexander von Humboldt Fellowship ; National Natural Science Foundation of China(21504038 ; Fundamental Research Funds for the Central Universities ; Shenzhen Science and Technology Innovation Committee(JCYJ20160531151105346) ; Marie Curie Curie Intro-European Fellowship ; 1000 Youth Talents Plan of China ; ERC ; 51672225)
WOS记录号WOS:000393532300034
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/21928
专题湿法冶金清洁生产技术国家工程实验室
作者单位1.Chinese Acad Sci, Inst Proc Engn, Natl Engn Lab Hydrometallurg Cleaner Prod Technol, Beijing 100190, Peoples R China
2.Nanjing Univ, Kuang Yarning Honors Sch, Nanjing 210093, Jiangsu, Peoples R China
3.Max Planck Inst Colloids & Interfaces, Wissensch Pk Golm,Muhlenberg 1, D-14476 Potsdam, Germany
4.Univ Liverpool, Dept Chem, Stephenson Inst Renewable Energy, Liverpool L69 7ZD, Merseyside, England
5.Northwestern Polytech Univ, Sch Mat Sci & Engn, Ctr Nano Energy Mat, State Key Lab Solidificat Proc, Xian 710072, Peoples R China
6.Nanjing Univ, Shenzhen Inst Res, Shenzhen 518057, Peoples R China
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Li, Guo Liang,Hu, Jinglei,Wang, Hongqiang,et al. Polymer-decorated anisotropic silica nanotubes with combined shape and surface properties for guest delivery[J]. POLYMER,2017,109:332-338.
APA Li, Guo Liang.,Hu, Jinglei.,Wang, Hongqiang.,Pilz-Allen, Christine.,Wang, Junpeng.,...&Shchukin, Dmitry G..(2017).Polymer-decorated anisotropic silica nanotubes with combined shape and surface properties for guest delivery.POLYMER,109,332-338.
MLA Li, Guo Liang,et al."Polymer-decorated anisotropic silica nanotubes with combined shape and surface properties for guest delivery".POLYMER 109(2017):332-338.
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