CAS OpenIR  > 湿法冶金清洁生产技术国家工程实验室
Polymer-decorated anisotropic silica nanotubes with combined shape and surface properties for guest delivery
Li, Guo Liang1,3; Hu, Jinglei2,6; Wang, Hongqiang4,5; Pilz-Allen, Christine3; Wang, Junpeng1; Qi, Tao1; Moehwald, Helmuth3; Shchukin, Dmitry G.4
2017-01-27
Source PublicationPOLYMER
ISSN0032-3861
Volume109Pages:332-338
Abstract

We report on amphiphilic diblock copolymer-decorated anisotropic silica nanotubes with well-defined dual functions of shape and surface properties in one nanocontainer. Amphiphilic poly(lactic acid)block-poly(ethylene glycol) (PLA-b-PEG) diblock copolymers are covalently grafted to the surface of mesoporous silica nanotubes via silane chemistry and esterification. The released percentage of probe molecules from the resultant silica-g-(PLA-b-PEG) hybrid nanocontainer is around 40% over a release time of 48 h, in contrast to 90% from bare silica nanotubes prior to surface modification. The diblock copolymer-decorated anisotropic nanocontainers with large aspect ratio lead to enhanced viability of NIH 3T3 fibroblast cells. A theoretical model based on the free energy cost for cell membranes to encapsulate nanocontainers is utilized to understand the cytotoxicity. This work demonstrates that the release dynamics of the active molecules and the interaction of hybrid nanocontainers with cell membranes can be regulated by the synergistic effect of nanocontainer shape and surface properties. (C) 2016 Elsevier Ltd. All rights reserved.

KeywordAnisotropic Nanocontainer Silica/polymer Hybrids Controlled Release
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1016/j.polymer.2016.12.048
Indexed BySCI
Language英语
WOS KeywordDrug-delivery ; Block-copolymers ; Click-chemistry ; Nanoparticles ; Oxide ; Therapy ; Core ; Nanocontainers ; Nanostructures ; Nanoreactors
WOS Research AreaPolymer Science
WOS SubjectPolymer Science
Funding OrganizationOne Hundred Talent Program of Chinese Academy of Sciences ; Alexander von Humboldt Fellowship ; National Natural Science Foundation of China(21504038 ; Fundamental Research Funds for the Central Universities ; Shenzhen Science and Technology Innovation Committee(JCYJ20160531151105346) ; Marie Curie Curie Intro-European Fellowship ; 1000 Youth Talents Plan of China ; ERC ; 51672225)
WOS IDWOS:000393532300034
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/21928
Collection湿法冶金清洁生产技术国家工程实验室
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Engn Lab Hydrometallurg Cleaner Prod Technol, Beijing 100190, Peoples R China
2.Nanjing Univ, Kuang Yarning Honors Sch, Nanjing 210093, Jiangsu, Peoples R China
3.Max Planck Inst Colloids & Interfaces, Wissensch Pk Golm,Muhlenberg 1, D-14476 Potsdam, Germany
4.Univ Liverpool, Dept Chem, Stephenson Inst Renewable Energy, Liverpool L69 7ZD, Merseyside, England
5.Northwestern Polytech Univ, Sch Mat Sci & Engn, Ctr Nano Energy Mat, State Key Lab Solidificat Proc, Xian 710072, Peoples R China
6.Nanjing Univ, Shenzhen Inst Res, Shenzhen 518057, Peoples R China
Recommended Citation
GB/T 7714
Li, Guo Liang,Hu, Jinglei,Wang, Hongqiang,et al. Polymer-decorated anisotropic silica nanotubes with combined shape and surface properties for guest delivery[J]. POLYMER,2017,109:332-338.
APA Li, Guo Liang.,Hu, Jinglei.,Wang, Hongqiang.,Pilz-Allen, Christine.,Wang, Junpeng.,...&Shchukin, Dmitry G..(2017).Polymer-decorated anisotropic silica nanotubes with combined shape and surface properties for guest delivery.POLYMER,109,332-338.
MLA Li, Guo Liang,et al."Polymer-decorated anisotropic silica nanotubes with combined shape and surface properties for guest delivery".POLYMER 109(2017):332-338.
Files in This Item:
File Name/Size DocType Version Access License
Polymer-decorated an(1780KB)期刊论文出版稿限制开放CC BY-NC-SAApplication Full Text
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li, Guo Liang]'s Articles
[Hu, Jinglei]'s Articles
[Wang, Hongqiang]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, Guo Liang]'s Articles
[Hu, Jinglei]'s Articles
[Wang, Hongqiang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, Guo Liang]'s Articles
[Hu, Jinglei]'s Articles
[Wang, Hongqiang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.