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Biological Photothermal Nanodots Based on Self-Assembly of Peptide Porphyrin Conjugates for Antitumor Therapy
Zou, Qianli1; Abbas, Manzar1,3; Zhao, Luyang1; Li, Shukun1,3; Shen, Guizhi1; Yan, Xuehai1,2
2017-02-08
Source PublicationJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
ISSN0002-7863
Volume139Issue:5Pages:1921-1927
Abstract

Photothermal agents can harvest light energy and convert it into heat, offering a targeted and remote controlled way to destroy carcinomatous cells and tissues. Inspired by the biological organization of polypeptides and porphyrins in living systems, here we have developed a supramolecular strategy to fabricate photothermal nanodots through peptide-modulated self-assembly of photoactive porphyrins. The self-assembling nature of porphyrins induces the formation of Taggregates as substructures of the nanodots, and thus enables the fabrication of nanodots with totally inhibited fluorescence emission and singlet oxygen production, leading to a high light-to-heat conversion efficiency of the nanodots. The peptide moieties not only provide aqueous stability for the nanodots through hydrophilic interactions, but also provide a spatial barrier between porphyrin groups to inhibit the further growth of nanodots through the strong 7r-stacking interactions. Thermographic imaging reveals that the conversion of light to heat based on the nanodots is efficient in vitro and in vivo, enabling the nanodots to be applied for photothermal acoustic imaging and antitumor therapy. Antitumor therapy results show that these nanodots are highly biocompatible photothermal agents for tumor ablation, demonstrating the feasibility of using bioinspired nanostructures of self-assembling biomaterials for biomedical photoactive applications.

SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1021/jacs.6b11382
Indexed BySCI
Language英语
WOS KeywordIn-vivo ; Cancer-therapy ; Functional Materials ; Carbon Nanotubes ; Living Mice ; Nanoparticles ; Agents ; Nanoarchitectonics ; Nanocrystals ; Nanospheres
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China(21522307 ; Talent Fund of the Recruitment Program of Global Youth Experts ; Chinese Academy of Sciences(QYZDB-SSW-JSC034) ; 21473208 ; 51403214 ; 91434103)
WOS IDWOS:000393848400041
Citation statistics
Cited Times:204[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/21952
Collection生化工程国家重点实验室
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Zou, Qianli,Abbas, Manzar,Zhao, Luyang,et al. Biological Photothermal Nanodots Based on Self-Assembly of Peptide Porphyrin Conjugates for Antitumor Therapy[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2017,139(5):1921-1927.
APA Zou, Qianli,Abbas, Manzar,Zhao, Luyang,Li, Shukun,Shen, Guizhi,&Yan, Xuehai.(2017).Biological Photothermal Nanodots Based on Self-Assembly of Peptide Porphyrin Conjugates for Antitumor Therapy.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,139(5),1921-1927.
MLA Zou, Qianli,et al."Biological Photothermal Nanodots Based on Self-Assembly of Peptide Porphyrin Conjugates for Antitumor Therapy".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 139.5(2017):1921-1927.
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