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Biological Photothermal Nanodots Based on Self-Assembly of Peptide Porphyrin Conjugates for Antitumor Therapy
Zou, Qianli1; Abbas, Manzar1,3; Zhao, Luyang1; Li, Shukun1,3; Shen, Guizhi1; Yan, Xuehai1,2
2017-02-08
发表期刊JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
ISSN0002-7863
卷号139期号:5页码:1921-1927
摘要

Photothermal agents can harvest light energy and convert it into heat, offering a targeted and remote controlled way to destroy carcinomatous cells and tissues. Inspired by the biological organization of polypeptides and porphyrins in living systems, here we have developed a supramolecular strategy to fabricate photothermal nanodots through peptide-modulated self-assembly of photoactive porphyrins. The self-assembling nature of porphyrins induces the formation of Taggregates as substructures of the nanodots, and thus enables the fabrication of nanodots with totally inhibited fluorescence emission and singlet oxygen production, leading to a high light-to-heat conversion efficiency of the nanodots. The peptide moieties not only provide aqueous stability for the nanodots through hydrophilic interactions, but also provide a spatial barrier between porphyrin groups to inhibit the further growth of nanodots through the strong 7r-stacking interactions. Thermographic imaging reveals that the conversion of light to heat based on the nanodots is efficient in vitro and in vivo, enabling the nanodots to be applied for photothermal acoustic imaging and antitumor therapy. Antitumor therapy results show that these nanodots are highly biocompatible photothermal agents for tumor ablation, demonstrating the feasibility of using bioinspired nanostructures of self-assembling biomaterials for biomedical photoactive applications.

文章类型Article
WOS标题词Science & Technology ; Physical Sciences
DOI10.1021/jacs.6b11382
收录类别SCI
语种英语
关键词[WOS]In-vivo ; Cancer-therapy ; Functional Materials ; Carbon Nanotubes ; Living Mice ; Nanoparticles ; Agents ; Nanoarchitectonics ; Nanocrystals ; Nanospheres
WOS研究方向Chemistry
WOS类目Chemistry, Multidisciplinary
项目资助者National Natural Science Foundation of China(21522307 ; Talent Fund of the Recruitment Program of Global Youth Experts ; Chinese Academy of Sciences(QYZDB-SSW-JSC034) ; 21473208 ; 51403214 ; 91434103)
WOS记录号WOS:000393848400041
引用统计
被引频次:130[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/21952
专题生化工程国家重点实验室
作者单位1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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GB/T 7714
Zou, Qianli,Abbas, Manzar,Zhao, Luyang,et al. Biological Photothermal Nanodots Based on Self-Assembly of Peptide Porphyrin Conjugates for Antitumor Therapy[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2017,139(5):1921-1927.
APA Zou, Qianli,Abbas, Manzar,Zhao, Luyang,Li, Shukun,Shen, Guizhi,&Yan, Xuehai.(2017).Biological Photothermal Nanodots Based on Self-Assembly of Peptide Porphyrin Conjugates for Antitumor Therapy.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,139(5),1921-1927.
MLA Zou, Qianli,et al."Biological Photothermal Nanodots Based on Self-Assembly of Peptide Porphyrin Conjugates for Antitumor Therapy".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 139.5(2017):1921-1927.
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