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Water-Insoluble Photosensitizer Nanocolloids Stabilized by Supramolecular Interfacial Assembly towards Photodynamic Therapy
Liu, Yamei1,2; Ma, Kai1,2; Jiao, Tifeng1,2; Xing, Ruirui1,2; Shen, Guizhi3; Yan, Xuehai3
2017-02-23
发表期刊SCIENTIFIC REPORTS
ISSN2045-2322
卷号7
摘要Nanoengineering of hydrophobic photosensitizers (PSs) is a promising approach for improved tumor delivery and enhanced photodynamic therapy (PDT) efficiency. A variety of delivery carriers have been developed for tumor delivery of PSs through the enhanced permeation and retention (EPR) effect. However, a high-performance PS delivery system with minimum use of carrier materials with excellent biocompatibility is highly appreciated. In this work, we utilized the spatiotemporal interfacial adhesion and assembly of supramolecular coordination to achieve the nanoengineering of water-insoluble photosensitizer Chlorin e6 (Ce6). The hydrophobic Ce6 nanoparticles are well stabilized in a aqueous medium by the interfacially-assembled film due to the coordination polymerization of tannic acid (TA) and ferric iron (Fe(III)). The resulting Ce6@ TA-Fe(III) complex nanoparticles (referenced as Ce6@ TA-Fe(III) NPs) significantly improves the drug loading content (similar to 65%) and have an average size of 60 nm. The Ce6@TA-Fe(III) NPs are almost non-emissive as the aggregated states, but they can light up after intracellular internalization, which thus realizes low dark toxicity and excellent phototoxicity under laser irradiation. The Ce6@TA-Fe(III) NPs prolong blood circulation, promote tumor-selective accumulation of PSs, and enhanced antitumor efficacy in comparison to the free-carrier Ce6 in vivo evaluation.
文章类型Article
WOS标题词Science & Technology
DOI10.1038/srep42978
收录类别SCI
语种英语
关键词[WOS]DRUG-DELIVERY ; NANOPARTICLES ; PROTEIN ; MECHANISMS ; CANCER ; LOCALIZATION ; DESTRUCTION ; LIPOSOMES ; NANODRUGS ; VEHICLES
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
项目资助者National Natural Science Foundation of China(21522307 ; Talent Fund of the Recruitment Program of Global Youth Experts ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences(QYZDB-SSW-JSC034) ; Science Foundation for the Excellent Youth Scholars from Universities and Colleges of Hebei Province(YQ2013026) ; Support Program for the Top Young Talents of Hebei Province ; Post-graduate's Innovation Fund Project of Hebei Province ; China Postdoctoral Science Foundation(2015M580214) ; Scientific and Technological Research and Development Program of Qinhuangdao City(201502A006) ; 21473208 ; 21473153 ; 21603233)
WOS记录号WOS:000394766100001
引用统计
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/21957
专题生化工程国家重点实验室
作者单位1.Yanshan Univ, State Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Peoples R China
2.Yanshan Univ, Sch Environm & Chem Engn, Hebei Key Lab Appl Chem, Qinhuangdao 066004, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
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GB/T 7714
Liu, Yamei,Ma, Kai,Jiao, Tifeng,et al. Water-Insoluble Photosensitizer Nanocolloids Stabilized by Supramolecular Interfacial Assembly towards Photodynamic Therapy[J]. SCIENTIFIC REPORTS,2017,7.
APA Liu, Yamei,Ma, Kai,Jiao, Tifeng,Xing, Ruirui,Shen, Guizhi,&Yan, Xuehai.(2017).Water-Insoluble Photosensitizer Nanocolloids Stabilized by Supramolecular Interfacial Assembly towards Photodynamic Therapy.SCIENTIFIC REPORTS,7.
MLA Liu, Yamei,et al."Water-Insoluble Photosensitizer Nanocolloids Stabilized by Supramolecular Interfacial Assembly towards Photodynamic Therapy".SCIENTIFIC REPORTS 7(2017).
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