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Water-Insoluble Photosensitizer Nanocolloids Stabilized by Supramolecular Interfacial Assembly towards Photodynamic Therapy
Liu, Yamei1,2; Ma, Kai1,2; Jiao, Tifeng1,2; Xing, Ruirui1,2; Shen, Guizhi3; Yan, Xuehai3
2017-02-23
Source PublicationSCIENTIFIC REPORTS
ISSN2045-2322
Volume7
Abstract

Nanoengineering of hydrophobic photosensitizers (PSs) is a promising approach for improved tumor delivery and enhanced photodynamic therapy (PDT) efficiency. A variety of delivery carriers have been developed for tumor delivery of PSs through the enhanced permeation and retention (EPR) effect. However, a high-performance PS delivery system with minimum use of carrier materials with excellent biocompatibility is highly appreciated. In this work, we utilized the spatiotemporal interfacial adhesion and assembly of supramolecular coordination to achieve the nanoengineering of water-insoluble photosensitizer Chlorin e6 (Ce6). The hydrophobic Ce6 nanoparticles are well stabilized in a aqueous medium by the interfacially-assembled film due to the coordination polymerization of tannic acid (TA) and ferric iron (Fe(III)). The resulting Ce6@ TA-Fe(III) complex nanoparticles (referenced as Ce6@ TA-Fe(III) NPs) significantly improves the drug loading content (similar to 65%) and have an average size of 60 nm. The Ce6@TA-Fe(III) NPs are almost non-emissive as the aggregated states, but they can light up after intracellular internalization, which thus realizes low dark toxicity and excellent phototoxicity under laser irradiation. The Ce6@TA-Fe(III) NPs prolong blood circulation, promote tumor-selective accumulation of PSs, and enhanced antitumor efficacy in comparison to the free-carrier Ce6 in vivo evaluation.

SubtypeArticle
WOS HeadingsScience & Technology
DOI10.1038/srep42978
Indexed BySCI
Language英语
WOS KeywordDrug-delivery ; Nanoparticles ; Protein ; Mechanisms ; Cancer ; Localization ; Destruction ; Liposomes ; Nanodrugs ; Vehicles
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
Funding OrganizationNational Natural Science Foundation of China(21522307 ; Talent Fund of the Recruitment Program of Global Youth Experts ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences(QYZDB-SSW-JSC034) ; Science Foundation for the Excellent Youth Scholars from Universities and Colleges of Hebei Province(YQ2013026) ; Support Program for the Top Young Talents of Hebei Province ; Post-graduate's Innovation Fund Project of Hebei Province ; China Postdoctoral Science Foundation(2015M580214) ; Scientific and Technological Research and Development Program of Qinhuangdao City(201502A006) ; 21473208 ; 21473153 ; 21603233)
WOS IDWOS:000394766100001
Citation statistics
Cited Times:37[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/21957
Collection生化工程国家重点实验室
Affiliation1.Yanshan Univ, State Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Peoples R China
2.Yanshan Univ, Sch Environm & Chem Engn, Hebei Key Lab Appl Chem, Qinhuangdao 066004, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Liu, Yamei,Ma, Kai,Jiao, Tifeng,et al. Water-Insoluble Photosensitizer Nanocolloids Stabilized by Supramolecular Interfacial Assembly towards Photodynamic Therapy[J]. SCIENTIFIC REPORTS,2017,7.
APA Liu, Yamei,Ma, Kai,Jiao, Tifeng,Xing, Ruirui,Shen, Guizhi,&Yan, Xuehai.(2017).Water-Insoluble Photosensitizer Nanocolloids Stabilized by Supramolecular Interfacial Assembly towards Photodynamic Therapy.SCIENTIFIC REPORTS,7.
MLA Liu, Yamei,et al."Water-Insoluble Photosensitizer Nanocolloids Stabilized by Supramolecular Interfacial Assembly towards Photodynamic Therapy".SCIENTIFIC REPORTS 7(2017).
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