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PEGylated graphene oxide elicits strong immunological responses despite surface passivation
Luo, Nana1,2; Weber, Jeffrey K.3; Wang, Shuang1,2; Luan, Binquan3; Yue, Hua1; Xi, Xiaobo1,2; Du, Jing4; Yang, Zaixing5,6; Wei, Wei1; Zhou, Ruhong3,5,6,7; Ma, Guanghui1,2,8
2017-02-24
发表期刊NATURE COMMUNICATIONS
ISSN2041-1723
卷号8
摘要Engineered nanomaterials promise to transform medicine at the bio-nano interface. However, it is important to elucidate how synthetic nanomaterials interact with critical biological systems before such products can be safely utilized in humans. Past evidence suggests that polyethylene glycol-functionalized (PEGylated) nanomaterials are largely biocompatible and elicit less dramatic immune responses than their pristine counterparts. We here report results that contradict these findings. We find that PEGylated graphene oxide nanosheets (nGO-PEGs) stimulate potent cytokine responses in peritoneal macrophages, despite not being internalized. Atomistic molecular dynamics simulations support a mechanism by which nGO-PEGs preferentially adsorb onto and/or partially insert into cell membranes, thereby amplifying interactions with stimulatory surface receptors. Further experiments demonstrate that nGO-PEG indeed provokes cytokine secretion by enhancing integrin b8-related signalling pathways. The present results inform that surface passivation does not always prevent immunological reactions to 2D nanomaterials but also suggest applications for PEGylated nanomaterials wherein immune stimulation is desired.
文章类型Article
WOS标题词Science & Technology
DOI10.1038/ncomms14537
收录类别SCI
语种英语
关键词[WOS]WALLED CARBON NANOTUBES ; PROTEIN CORONA ; CELLULAR INTERNALIZATION ; POLYETHYLENE-GLYCOL ; MOLECULAR-DYNAMICS ; NANOPARTICLE SIZE ; NANOMATERIALS ; NANOSHEETS ; MEMBRANE ; SYSTEMS
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
项目资助者National Science and Technology Major Project(2014ZX09102045-004) ; 973 Program(2013CB531500) ; National Natural Science Foundation of China(21320102003 ; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) ; IBM Blue Gene Science Program(W125859 ; Tsinghua University(2012Z02133) ; 11374221 ; W1464125 ; 11574224 ; W1464164) ; 31370018)
WOS记录号WOS:000394653500001
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/21960
专题生化工程国家重点实验室
作者单位1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.IBM Thomas J Watson Res Ctr, Computat Biol Ctr, Yorktown Hts, NY 10598 USA
4.Tsinghua Univ, Dept Engn Mech, Inst Biomech & Med Engn, Beijing 100084, Peoples R China
5.Soochow Univ, SRMP, Inst Quantitat Biol & Med, Suzhou 215123, Peoples R China
6.Soochow Univ, Jiangsu Higher Educ Inst, Collaborat Innovat Ctr Radiat Med, RAD X, Suzhou 215123, Peoples R China
7.Columbia Univ, Dept Chem, New York, NY 10027 USA
8.Nanjing Tech Univ, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Nanjing 211816, Jiangsu, Peoples R China
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GB/T 7714
Luo, Nana,Weber, Jeffrey K.,Wang, Shuang,et al. PEGylated graphene oxide elicits strong immunological responses despite surface passivation[J]. NATURE COMMUNICATIONS,2017,8.
APA Luo, Nana.,Weber, Jeffrey K..,Wang, Shuang.,Luan, Binquan.,Yue, Hua.,...&Ma, Guanghui.(2017).PEGylated graphene oxide elicits strong immunological responses despite surface passivation.NATURE COMMUNICATIONS,8.
MLA Luo, Nana,et al."PEGylated graphene oxide elicits strong immunological responses despite surface passivation".NATURE COMMUNICATIONS 8(2017).
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