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Using porous CaCO3/hyaluronic acid nanocages to accommodate hydrophobic photosensitizer in aqueous media for photodynamic therapy
Dong, Qianqian1,2; Li, Jieling2; Cui, Lingyun2; Jian, Honglei2; Wang, Anhe2; Bai, Shuo2
2017-03-05
发表期刊COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
ISSN0927-7757
卷号516页码:190-198
摘要The solubility and stability of hydrophobic photosensitizer in aqueous solution have a great effect on the efficiency of Photodynamic Therapy (PDT) in cancer treatment. Herein, porous CaCO3 nanoparticles with a size about 250 nm were prepared as a carrier for the photosensitizer Hypocrellin B (HB) to improve the encapsulation and delivery in aqueous solution. The encapsulation dosage of HB by porous CaCO3 nanoparticles was investigated and proved to be concentration dependent. After modified by cross-linked targeting molecule hyaluronic acid (HA), the hybrid nanoparticles were demonstrated the advantages for HB release by pH sensitive structure and enhancement of PDT cytotoxicity to cancer cells. The hybrid nanoparticles obtained here are supposed to have a great potential application in the PDT. (C) 2016 Elsevier B.V. All rights reserved.
关键词Caco3 Nanoparticles Hyaluronic Acid Photosensitizer Photodynamic Therapy
文章类型Article
WOS标题词Science & Technology ; Physical Sciences
DOI10.1016/j.colsurfa.2016.12.027
收录类别SCI
语种英语
关键词[WOS]SILICA NANOPARTICLES ; SOLVENT EXCHANGE ; GOLD NANOCAGES ; DRUG-RELEASE ; CANCER-CELLS ; PARTICLES ; DELIVERY ; BIOMINERALIZATION ; CAPSULES ; BEADS
WOS研究方向Chemistry
WOS类目Chemistry, Physical
项目资助者Talent Fund of the Recruitment Program of Global Youth Experts ; National Nature Science Foundation of China(51303038 ; National Basic Research Program of China(2013CB932800) ; National key foundation for exploring scientific instrument(2013YQ16055108) ; 21273055)
WOS记录号WOS:000393727700021
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ipe.ac.cn/handle/122111/21962
专题生化工程国家重点实验室
作者单位1.Harbin Univ Sci & Technol, Coll Chem & Environm Engn, Harbin 150040, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
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Dong, Qianqian,Li, Jieling,Cui, Lingyun,et al. Using porous CaCO3/hyaluronic acid nanocages to accommodate hydrophobic photosensitizer in aqueous media for photodynamic therapy[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2017,516:190-198.
APA Dong, Qianqian,Li, Jieling,Cui, Lingyun,Jian, Honglei,Wang, Anhe,&Bai, Shuo.(2017).Using porous CaCO3/hyaluronic acid nanocages to accommodate hydrophobic photosensitizer in aqueous media for photodynamic therapy.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,516,190-198.
MLA Dong, Qianqian,et al."Using porous CaCO3/hyaluronic acid nanocages to accommodate hydrophobic photosensitizer in aqueous media for photodynamic therapy".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 516(2017):190-198.
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